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2ND SEM BIOCHEMISTRY > [RECALLS] Heme, Porphyrins And Nucleotides > Flashcards

[RECALLS] Heme, Porphyrins And Nucleotides Flashcards

1
Q

5th coordinating carbon of myoglobin is linked to:

A

His F8

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2
Q

6th coordinating carbon of myoglobin is linked to:

A

His F7

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3
Q

Fetal hemoglobin

A

Alpha 2

Gamma 2

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4
Q

All are true of myoglobin except

A

Releases O2 when PO2 of muscles decrease to 20 mmHg during strenous exercise

*It should be 5 mmHg

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5
Q

Hemoglobinopathy where in His F8 is replaced by tyrosine

A

Hemoglobin M

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6
Q

Oxygen dissociation curve of myoglobin

A

Hyperbolic

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7
Q

Oxygen dissociation curve of hemoglobin

A

Sigmoidal

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8
Q

Condition wherein alpha or beta globin chains are absent or decreased in number

A

Thalassemia

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9
Q

O2 binds to hemoglobin tetramer more readily if other O2 molecules are already bound

A

Cooperative binding

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10
Q

Largest repository of heme

A

RBC

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11
Q

Heme iron is ferric

A

Methemoglobinemia

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12
Q

In cooperative binding

A

Iron is slightly out of place secondary to sterric repulsion between proximal His and N atoms or porphyrin

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13
Q

Reciprocal coupling of proton and O2 binding

A

Bohr effect

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14
Q

Iron oxidized to ferric form

A

Hemin

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15
Q

Iron lie outside the plane of heme

A

Deoxygenated hemoglobin

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16
Q

Which of the following is true

A

Unoxygenated myoglobin iron lies outside the heme ring

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17
Q

Low PO2

A

Synthesis of 2,3 BPG

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18
Q

Direct measure of the activity of heme oxygenase

A

CO of expired air

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19
Q

Heme coordination process except

A

Carboxylation and decarboxylation

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20
Q

Which are colorless compounds

A

Porphyrinogens (Urobilinogens)

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21
Q

Porphyrin ring

A

Hyrophobic

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22
Q

Bilirubin in bile

A

Conjugated bilirubin

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23
Q

Blue-green color

A

Biliverdin

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24
Q

Albumin

A

Left in plasma

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25
Q

Location of heme oxygenase

A

Endoplasmic reticulum

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26
Q

Conjugation of bile catalyzed by

A

UDP glucoronyl transferase

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27
Q

Has large capacity that even under the pathologic conditions, transport does not appear to be rate-limiting for metabolism of bilirubin

A

Facilitated transport system

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28
Q

Derivatives of purine and the pyrimidine that has a sugar inked to a ring N

A

Nucleosides

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29
Q

Sugar is linked to the heterocyclic base via:

A

B, N-glycosidic bond

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30
Q

Which is true of sugar that is linked to a heterocyclic base:

A

N-1 pyrimidine

N-9 purine

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31
Q

Nucleoside with a phosphoryl group esterified to a hydroxyl group of the sugar

A

Mononucleosides

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32
Q

Utilized in transfer of formy-group 1

A

N10-formyl-tetrahydrofolic acid

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33
Q

Nucleoside with an attached phosphate group

A

Monophosphate

34
Q

Free nucleotides (intermediates in the catabolism of adenine and guanine)

A

Xanthine, hypoxanthine, uric acid

35
Q

What permits purines and pyrimidines to function as group transfer reagents?

A

Nucleoside triphosphates have high group transfer potential

36
Q

Nucleoside derivative of guanine

A

Guanosine

37
Q

Nucleoside derivative of adenine

A

Adenosine

38
Q

Nucleoside derivative of uracil

A

Uridine

39
Q

Hydrogen atom attached to #2 carbon

A

Deoxyribose

40
Q

True about P450 except

A

PO2 half saturates myoglobin

41
Q

Most compact representation with the 5’ end on the left

A

Base sequence

42
Q

Fetal hemoglobin

A

Alpha 2

Gamma 2

43
Q

All are true of myoglobin except

A

Releases O2 when PO2 of muscles decrease to 20 mmHg during strenous exercise

*It should be 5 mmHg

44
Q

Hemoglobinopathy where in His F8 is replaced by tyrosine

A

Hemoglobin M

45
Q

Oxygen dissociation curve of myoglobin

A

Hyperbolic

46
Q

Oxygen dissociation curve of hemoglobin

A

Sigmoidal

47
Q

Condition wherein alpha or beta globin chains are absent or decreased in number

A

Thalassemia

48
Q

O2 binds to hemoglobin tetramer more readily if other O2 molecules are already bound

A

Cooperative binding

49
Q

Largest repository of heme

A

RBC

50
Q

Heme iron is ferric

A

Methemoglobinemia

51
Q

In cooperative binding

A

Iron is slightly out of place secondary to sterric repulsion between proximal His and N atoms or porphyrin

52
Q

Reciprocal coupling of proton and O2 binding

A

Bohr effect

53
Q

Iron oxidized to ferric form

A

Hemin

54
Q

Iron lie outside the plane of heme

A

Deoxygenated hemoglobin

55
Q

Which of the following is true

A

Unoxygenated myoglobin iron lies outside the heme ring

56
Q

Low PO2

A

Synthesis of 2,3 BPG

57
Q

Direct measure of the activity of heme oxygenase

A

CO of expired air

58
Q

Heme coordination process except

A

Carboxylation and decarboxylation

59
Q

Which are colorless compounds

A

Porphyrinogens (Urobilinogens)

60
Q

Porphyrin ring

A

Hyrophobic

61
Q

Bilirubin in bile

A

Conjugated bilirubin

62
Q

Blue-green color

A

Biliverdin

63
Q

Albumin

A

Left in plasma

64
Q

Location of heme oxygenase

A

Endoplasmic reticulum

65
Q

Conjugation of bile catalyzed by

A

UDP glucoronyl transferase

66
Q

Has large capacity that even under the pathologic conditions, transport does not appear to be rate-limiting for metabolism of bilirubin

A

Facilitated transport system

67
Q

Derivatives of purine and the pyrimidine that has a sugar inked to a ring N

A

Nucleosides

68
Q

Sugar is linked to the heterocyclic base via:

A

B, N-glycosidic bond

69
Q

Which is true of sugar that is linked to a heterocyclic base:

A

N-1 pyrimidine

N-9 purine

70
Q

Nucleoside with a phosphoryl group esterified to a hydroxyl group of the sugar

A

Mononucleosides

71
Q

Utilized in transfer of formy-group 1

A

N10-formyl-tetrahydrofolic acid

72
Q

Nucleoside with an attached phosphate group

A

Monophosphate

73
Q

Free nucleotides (intermediates in the catabolism of adenine and guanine)

A

Xanthine, hypoxanthine, uric acid

74
Q

What permits purines and pyrimidines to function as group transfer reagents?

A

Nucleoside triphosphates have high group transfer potential

75
Q

Nucleoside derivative of guanine

A

Guanosine

76
Q

Nucleoside derivative of adenine

A

Adenosine

77
Q

Nucleoside derivative of uracil

A

Uridine

78
Q

Hydrogen atom attached to #2 carbon

A

Deoxyribose

79
Q

True about P450 except

A

PO2 half saturates myoglobin

80
Q

Most compact representation with the 5’ end on the left

A

Base sequence

2ND SEM BIOCHEMISTRY (33 decks)

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