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2ND SEM BIOCHEMISTRY > [RECALLS] Immunoglobulins and plasma proteins > Flashcards

[RECALLS] Immunoglobulins and plasma proteins Flashcards

1
Q 
1. What form of iron is transported into the enterocyte via the divalent transporter 1?
A. Fe2+
B. Fe3+
C. Fe3+ transferring complex
D. All of the above
A

A

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2
Q

Plasma protein the downregulates the absorption of iron in the enterocytes?

A

hepcidin

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3
Q

Condensation of 1 glycine and 1 succinyl coA happens in the?

A

Mitochondria

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4
Q

Which of the following is true?

A

Unoxygenated myoglobin iron lies outside the heme ring

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5
Q

For maintenance of heme levels, there should be a coordination in between the following process, except:

A

Formation of globin / Turnover of proteins

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6
Q 
What is necessary to activate glycine?
A. NADP
B. NADPH
C. Pyridoxal Phosphate
D. Acetyl coA
A

C. Pyridoxal Phosphate

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7
Q

Passage through mitochondria must pass through 2 membranes, this process is called:

A

Translocation

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8
Q 
Which of the following has kappa light chain?
A. IgA
B. IgD
C. IgE
D. All of the abover
E. None of the above
A

B. IgD

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9
Q

All of the following are true of P50 except?
A. Measurement of 02 saturation
B. pO2 that half saturates a given myoglobin
C. Vary widely

A

B. pO2 that half saturates a given myoglobin

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10
Q 
As conjugated bilirubin reaches the terminal ileum and large intestine the glucoronides is removed by bacterial enzymes?
A. UDP-glucodehydrogenase
B. UDP- glucosyl transferase
C. Beta- glucoronidase
D. Biliverdin reductase
A

Answer: A/ C

A. UDP-glucodehydrogenase

C. Beta- glucoronidase

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11
Q

Reciprocal coupling of proton and O2 binding is called?

A

Bohr effect

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12
Q

The following abnormalities of alpha1 anti-trypsin can lead to liver disease

A

Lysine 342

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13
Q

When unconjugated bilirubin passes between blood brain barrier, it will produce?

A

Answer: Kernicterus

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14
Q

Deficiency of this enzyme will cause protoporphyria?

A

Answer: Protoporphyrinogen oxidase

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15
Q

Coproporphyrinogen oxidase acts only on?

A

Answer: Coproporphyrinogen III

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16
Q

1 month old infant with feeding difficulties, poor weight gain, bone changes, hair abnormalities, and recurrent convulsions; mutation in ATP7A
gene. Which of the ff is true?
A. Copper is not excreted in the bile
B. Liver is the primary organ affected
C. Copper is not included into apoenyzmes

A

Answer: C

C. Copper is not included into apoenyzmes

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17
Q

Condensation of four molecules of PBG in a head to tail manner I catalyzed by:

A

Answer: Uroporphyrinogen I synthase

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18
Q

What plasma protein that prevents precipitation in renal tubules?

A

Answer: Haptoglobin

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19
Q 
Approximately 85% of heme synthesis occurs primarily in the
A. Bone Marrow
B. Spleen
C. T cell
D. Lymphocytes
Answer: D
A

D. Lymphocytes

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20
Q

Acute intermittent porphyria:

A

Answer: PBG deaminase

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21
Q 
Catabolism after hemoglobin is destroyed:
A. Lipooxygenase pathway
B. Heme oxygenase system
C. Glucoronyl system
D. Heme oxidase
A

B. Heme oxygenase system

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22
Q 
True of heme except:
A. Heme can be found in the Hg
B. heme can be found in myoglobin
C. one atom of ferrous iron residues
D. Consists of 2 molecules of pyrrole linked by alpha methylene bridges
A

Answer:

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23
Q 
Immunoglobulin that is derived from only one gene
A. IgA
B. Ig D
C. IgE
D. All of the above
E. None of the above
A

Answer:

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24
Q 
Low pO2 in peripheral tissues promotes synthesis of :
A. HbF
B. 2,3 BPG
C. Residue H21
D. Lsy EF6 and HIS21
A

Answer: B

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25
Q

Force required for import across the inner membrane:

A

Proton motive force

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26
Q

This is the reason why CO is not completely displaced from heme iron?

A

Answer:

27
Q 
Hemoglobin is:
A. A monomer
B. Carrier of both O2 and CO2
C. Linear tetrapyrrole
D. A hemeprotein which carries O2 and delivers them from the lung capillaries
A

B. Carrier of both O2 and CO2

28
Q 
Unfolded proteins synthesized in the cystosolic polyribosomes and contain the mitochondrial matrix targeting sequence interact with?
A. MT-HSP60-HSP10
B. MT-HSP70-HSP10
C. MT-HSP40-HSP10
D. MT-HSP80-HSP10
A

A. MT-HSP60-HSP10

29
Q

Protein prior to enter in peroxisome
A. folded
B. unfolded

A

A. folded

30
Q

Increases in response to stimulation, what neutralizes this protease?
A. CRP
B. Alpha1 antitrypsin

A

B. Alpha1 antitrypsin

31
Q

From the mitochondria, outer membrane receptor TOM 20/22, proteins are transferred to this neighboring import channel?

A

Answer: TOM40

32
Q 
A target of macromolecule along nucleus and cytoplasm occurs bidirectionally through:
A. Nuclear importins
B. Nuclear localization signals
C. Nuclear pore complex
D. Nuclear export signals
A

Answer:

33
Q

True of O2 dissociation cuve of myoglobin except:

A

Answer: pO2 at muscle is not 20 mmHg

34
Q

Bilirubin bound to albumin predominantly found in:
A. Blood
B. Hepatocyte

A

Answer: A

35
Q

Unconjugated bile passes the BBB, it will produce?

A

Answer: Kernicterus

36
Q

Condensation of 1 glycine and 1 succinyl coA is processed in?

A

Answer: A

37
Q

The Negative regulator of ALAS 1

a. heme
b. myoglobin
c. hemolobin
d. carbon monoxide

A

A. Heme

38
Q 
Synthesizing y immunoglobulins.
A leukocyte
B t cell
C b cell
D enterocyte
A

Answer:

39
Q

5th coordinate position of iron in myoglobin in nitrogen ring

A

Answer: proximal his f8

40
Q

The following are products of rbc destruction except

a. ) globin
b. ) porphyrin
c. ) iron
d. ) apoprotein

A

Answer: D. apoprotein

41
Q

Four molecules of porphobilinogen condense in a head to tail manner to form tetrapyrrole called:

a. uroporphyrinogen I
b. uroporphyrinogen III
c. hydroxymethylbilane
d. coproporphyrinogen III

A

Answer:

42
Q

What disorder would tyrosine replace Histidine F8?

A

Hemoglobin M

43
Q 
The most common sign of liver dysfunction is:
A. Acholic stools
B. Jaundice
C. Weight loss
D. Pallor
A

Answer:

44
Q 
Electrophoresis allows resolution of plasma proteins into 5 bands. Which is a correct match?
A. Ceruloplasmin- B globulin
B. Haptoglobin- a2 globulin
C. Transferrin- a1 globulin
D. Iga- a1 globulin
A

Answer:

45
Q

Immunoglobulin that passes through placenta

A

IgG

46
Q

Most drugs are metabolized by this system in the liver.

A

Ans. Cytochrome p450

47
Q

Result from the partial or total absence of one or more alpha or beta chains of hemoglobin.

A

Answer: thalassemia

48
Q

Result from the partial or total absence of one or more alpha or beta chains of hemoglobin.

A

Answer: thalassemia

49
Q

Family of proteins that regulates the transport of … To the nucleus to the the cytoplasm:

A

RAN PROTEINS

50
Q

Ig present in secretions:

A

IgA

51
Q

Acute phase reactant that neutralizes proteases:

A

alpha 1 antitrypsin

52
Q

Subunit of fetal hemoglobin

A

Answer: A2G2

53
Q

Hyperbilirubinemia caused by except:

A

yung may ileum sa choices.

54
Q

The following are true of myoglobin, except:
A. Surface has charged amino acids
B. Surface can form hydrogen bond which reacts with each other & with water
C. Interior is nonpolar
D. Interior is stabilized by covalent bonds

A

D. Interior is stabilized by covalent bonds

55
Q 
This procedure separates plasma proteins so that they may viewed as separate bands with each characteristic peak.
A. Electrophoresis
B. Salting method
C. Labelling with radioactive isotope
D. Cell fusion
A

A. Electrophoresis

56
Q

Converts ferrous to ferric before transport from enterocyte to plasma.

A

Ans: hephaestin

57
Q

Coproporphirinogen Oxidase will only act on?

a. Coproporphirinogen I
b. Coproporphirinogen II
c. Coproporphirinogen III
d. Coproporphirinogen IV

A

c. Coproporphirinogen III

58
Q

What is the plasma protein that prevents precipitation in renal tubules?

A

Answer: Haptoglobin

59
Q

What is methemoglobin:

A

Answer: Ferric form of iron instead of Ferous

60
Q

Rate limiting reaction in heme formation

A

Answer: ALA Synthase

61
Q

Patient with profuse menstrual bleeding. Palor… Iron metabolism?

a. mRNA for TfR1 is degraded
b. Increased synthesis of hepcidin
c. Binding of irp to ire blocks translation of ferritin

A

c. Binding of irp to ire blocks translation of ferritin

62
Q 
Portion of Immunoglobulin structure that dictates specificity
A. Relatively Invariable Region
B. Constant Region
C. Complimentary Determinant Region
D. Framework Region
A

D. Framework Region

63
Q

Family of importins and exportins

A

Answer: karyopherins

2ND SEM BIOCHEMISTRY (33 decks)

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