[RECALLS] Immunoglobulins and plasma proteins Flashcards
1. What form of iron is transported into the enterocyte via the divalent transporter 1? A. Fe2+ B. Fe3+ C. Fe3+ transferring complex D. All of the above
A
Plasma protein the downregulates the absorption of iron in the enterocytes?
hepcidin
Condensation of 1 glycine and 1 succinyl coA happens in the?
Mitochondria
Which of the following is true?
Unoxygenated myoglobin iron lies outside the heme ring
For maintenance of heme levels, there should be a coordination in between the following process, except:
Formation of globin / Turnover of proteins
What is necessary to activate glycine? A. NADP B. NADPH C. Pyridoxal Phosphate D. Acetyl coA
C. Pyridoxal Phosphate
Passage through mitochondria must pass through 2 membranes, this process is called:
Translocation
Which of the following has kappa light chain? A. IgA B. IgD C. IgE D. All of the abover E. None of the above
B. IgD
All of the following are true of P50 except?
A. Measurement of 02 saturation
B. pO2 that half saturates a given myoglobin
C. Vary widely
B. pO2 that half saturates a given myoglobin
As conjugated bilirubin reaches the terminal ileum and large intestine the glucoronides is removed by bacterial enzymes? A. UDP-glucodehydrogenase B. UDP- glucosyl transferase C. Beta- glucoronidase D. Biliverdin reductase
Answer: A/ C
A. UDP-glucodehydrogenase
C. Beta- glucoronidase
Reciprocal coupling of proton and O2 binding is called?
Bohr effect
The following abnormalities of alpha1 anti-trypsin can lead to liver disease
Lysine 342
When unconjugated bilirubin passes between blood brain barrier, it will produce?
Answer: Kernicterus
Deficiency of this enzyme will cause protoporphyria?
Answer: Protoporphyrinogen oxidase
Coproporphyrinogen oxidase acts only on?
Answer: Coproporphyrinogen III
1 month old infant with feeding difficulties, poor weight gain, bone changes, hair abnormalities, and recurrent convulsions; mutation in ATP7A
gene. Which of the ff is true?
A. Copper is not excreted in the bile
B. Liver is the primary organ affected
C. Copper is not included into apoenyzmes
Answer: C
C. Copper is not included into apoenyzmes
Condensation of four molecules of PBG in a head to tail manner I catalyzed by:
Answer: Uroporphyrinogen I synthase
What plasma protein that prevents precipitation in renal tubules?
Answer: Haptoglobin
Approximately 85% of heme synthesis occurs primarily in the A. Bone Marrow B. Spleen C. T cell D. Lymphocytes Answer: D
D. Lymphocytes
Acute intermittent porphyria:
Answer: PBG deaminase
Catabolism after hemoglobin is destroyed: A. Lipooxygenase pathway B. Heme oxygenase system C. Glucoronyl system D. Heme oxidase
B. Heme oxygenase system
True of heme except: A. Heme can be found in the Hg B. heme can be found in myoglobin C. one atom of ferrous iron residues D. Consists of 2 molecules of pyrrole linked by alpha methylene bridges
Answer:
Immunoglobulin that is derived from only one gene A. IgA B. Ig D C. IgE D. All of the above E. None of the above
Answer:
Low pO2 in peripheral tissues promotes synthesis of : A. HbF B. 2,3 BPG C. Residue H21 D. Lsy EF6 and HIS21
Answer: B
Force required for import across the inner membrane:
Proton motive force
This is the reason why CO is not completely displaced from heme iron?
Answer:
Hemoglobin is: A. A monomer B. Carrier of both O2 and CO2 C. Linear tetrapyrrole D. A hemeprotein which carries O2 and delivers them from the lung capillaries
B. Carrier of both O2 and CO2
Unfolded proteins synthesized in the cystosolic polyribosomes and contain the mitochondrial matrix targeting sequence interact with? A. MT-HSP60-HSP10 B. MT-HSP70-HSP10 C. MT-HSP40-HSP10 D. MT-HSP80-HSP10
A. MT-HSP60-HSP10
Protein prior to enter in peroxisome
A. folded
B. unfolded
A. folded
Increases in response to stimulation, what neutralizes this protease?
A. CRP
B. Alpha1 antitrypsin
B. Alpha1 antitrypsin
From the mitochondria, outer membrane receptor TOM 20/22, proteins are transferred to this neighboring import channel?
Answer: TOM40
A target of macromolecule along nucleus and cytoplasm occurs bidirectionally through: A. Nuclear importins B. Nuclear localization signals C. Nuclear pore complex D. Nuclear export signals
Answer:
True of O2 dissociation cuve of myoglobin except:
Answer: pO2 at muscle is not 20 mmHg
Bilirubin bound to albumin predominantly found in:
A. Blood
B. Hepatocyte
Answer: A
Unconjugated bile passes the BBB, it will produce?
Answer: Kernicterus
Condensation of 1 glycine and 1 succinyl coA is processed in?
Answer: A
The Negative regulator of ALAS 1
a. heme
b. myoglobin
c. hemolobin
d. carbon monoxide
A. Heme
Synthesizing y immunoglobulins. A leukocyte B t cell C b cell D enterocyte
Answer:
5th coordinate position of iron in myoglobin in nitrogen ring
Answer: proximal his f8
The following are products of rbc destruction except
a. ) globin
b. ) porphyrin
c. ) iron
d. ) apoprotein
Answer: D. apoprotein
Four molecules of porphobilinogen condense in a head to tail manner to form tetrapyrrole called:
a. uroporphyrinogen I
b. uroporphyrinogen III
c. hydroxymethylbilane
d. coproporphyrinogen III
Answer:
What disorder would tyrosine replace Histidine F8?
Hemoglobin M
The most common sign of liver dysfunction is: A. Acholic stools B. Jaundice C. Weight loss D. Pallor
Answer:
Electrophoresis allows resolution of plasma proteins into 5 bands. Which is a correct match? A. Ceruloplasmin- B globulin B. Haptoglobin- a2 globulin C. Transferrin- a1 globulin D. Iga- a1 globulin
Answer:
Immunoglobulin that passes through placenta
IgG
Most drugs are metabolized by this system in the liver.
Ans. Cytochrome p450
Result from the partial or total absence of one or more alpha or beta chains of hemoglobin.
Answer: thalassemia
Result from the partial or total absence of one or more alpha or beta chains of hemoglobin.
Answer: thalassemia
Family of proteins that regulates the transport of … To the nucleus to the the cytoplasm:
RAN PROTEINS
Ig present in secretions:
IgA
Acute phase reactant that neutralizes proteases:
alpha 1 antitrypsin
Subunit of fetal hemoglobin
Answer: A2G2
Hyperbilirubinemia caused by except:
yung may ileum sa choices.
The following are true of myoglobin, except:
A. Surface has charged amino acids
B. Surface can form hydrogen bond which reacts with each other & with water
C. Interior is nonpolar
D. Interior is stabilized by covalent bonds
D. Interior is stabilized by covalent bonds
This procedure separates plasma proteins so that they may viewed as separate bands with each characteristic peak. A. Electrophoresis B. Salting method C. Labelling with radioactive isotope D. Cell fusion
A. Electrophoresis
Converts ferrous to ferric before transport from enterocyte to plasma.
Ans: hephaestin
Coproporphirinogen Oxidase will only act on?
a. Coproporphirinogen I
b. Coproporphirinogen II
c. Coproporphirinogen III
d. Coproporphirinogen IV
c. Coproporphirinogen III
What is the plasma protein that prevents precipitation in renal tubules?
Answer: Haptoglobin
What is methemoglobin:
Answer: Ferric form of iron instead of Ferous
Rate limiting reaction in heme formation
Answer: ALA Synthase
Patient with profuse menstrual bleeding. Palor… Iron metabolism?
a. mRNA for TfR1 is degraded
b. Increased synthesis of hepcidin
c. Binding of irp to ire blocks translation of ferritin
c. Binding of irp to ire blocks translation of ferritin
Portion of Immunoglobulin structure that dictates specificity A. Relatively Invariable Region B. Constant Region C. Complimentary Determinant Region D. Framework Region
D. Framework Region
Family of importins and exportins
Answer: karyopherins
