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MRCOG part 1 > Recalls 3 > Flashcards

Recalls 3 Flashcards

1
Q

What are the grading of evidence as per RCOG

A

A - RCTs, systematic reviews/meta-analyses of RCTs

B - non randomised but well conducted trials

C - case reports

D - expert opinion

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2
Q

What is the appendicular artery a branch of

A

Ileocolic

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3
Q

What is teh precursor for serotonin

A

Tryotophan

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4
Q

What is the precursor for dopamine

A

Tyrosine

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5
Q

Define:
Very common
Common
Uncommon
Rare
Very rare

A

1-1/10
1/10-1/100
1/100-1/1000
1/1000-1/10000
<1/10000

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6
Q

What type of molecule are histones

A

protein

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7
Q

Endometrial gland tumour with cartilage

A

Carcinosarcoma

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8
Q

What type of drug is mirabegron

A

Beta 3 adrenergic receptor agonsit

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9
Q

What type of drug is terbutaline

A

B2 agonist

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10
Q

What is a side effect of terbutaline?

MAternal tachy
Fetla tachy
Maternal brady
Fetal brady

A

Maternal tachy because it is a B2 AGONIST. Think opposite of BB

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11
Q

Which inflammatory cells are triggered by silicone implant spillage

A

Giant cells

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12
Q

What is the most common malignant tumour in term or preterm inflants

A

TERM - neuroblastoma

Pre-term = sacrocyccygeal teratoma (SCT)

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13
Q

What does exposure to Diethylstilbestrol (DES) lead to

A

It is an oestrogen that used to be used to try and prevent miscarriage.

Leads to clear cell cancer of vagina

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14
Q

Where is the active form of vitamin D produced

A
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15
Q

Explained Vit D metabolism

Where is it from

Where is it activated

A

Vit D2 - food
Vit D3 - skin

Changed in liver by 25-hydroxylase

Activated in kidney

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16
Q

Which of the cytotoxic drugs causes haemorrhagic cystitis

A

cyclophosphamide

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17
Q

Describe chemo man

A
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18
Q

What type of drug is clomifene

A

a SERM

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19
Q

Which drug causes PND when used postnatally

A

methyldopa

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20
Q

What is the lansfield grouping for streptococci

A

It groups strep into A,B,C etc based on the antigens made of carbohydrates o their cell wall

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21
Q

What is the commonest cause of delay in puberty in males

A

constitutional delay

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22
Q

What type of drug is ulipristal

A

SPRM

slsective progesterone receptor modulator

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23
Q

what is the termination point of the round ligament

A

The labia majora

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24
Q

What does the ductus venosus form

A

Ligamentum venosum

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25
Q

What does the umbilical vein form

A

ligamentum teres

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26
Q

What is the most common organism to colonise the copper iud

A

actinomyces

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27
Q

Which bacteria is depleted in BV

A

lactobactilus

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28
Q

Which is the most common organism causing fetal anaemia?

What else does it cause?

What is percentage fetal loss?

A

parvovirus B19

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29
Q

What is BMI formula

A

weight/square root of heing in M

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30
Q

Does sheehan syndrome affect anterior or posterior pituitary

A

Anterior

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31
Q

How is lactate converted to glucose

A

lactic acid cycle aka cori’s cycle

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32
Q

how to work out abgars

A

The things that give you a point of 1 are:

  • blue extremities
  • grimace rather than a cry
  • Flexion rather than being active
  • HR <100
  • Resps are gasping and irregular
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33
Q

What is the treatment for a MRSA wound infection

A

Vancomycin

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34
Q

Describe the route of estrone creation and estradiol creation

A
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35
Q

What is the most likely electrolyte disturbance from Bendroflumethiazide

A

hypokalaemia

36
Q

In the developing testis, which cells produce the mullerian inhibiting substance aka AMH

A

Sertoli cells

37
Q

Which enzyme in red blood cells buffers CO2

A

Carbonic anhydrase

38
Q

What is definition of maternal mortality and therefore how to figure it out

A

number of deaths/per births

x 100,000 as it is per 100,000

39
Q

What type iof receptor is the progesteron receptor

A

a nuclear transciption factor receptor.

Oestrogen is the same

40
Q

What causes kernicterus

A

bilirubin too high

Sulphonamides e.g. sulfasalazine

41
Q

How does insulin get activated

A

Removing C peptide

C peptide and insulin get sereted 1:1

42
Q

What is the function of mRNA

A

carrys info from DNA to ribosomes for protein making

TRANSLATION

It is made by TRANSCRIPTION

43
Q

Which tissues are particularly sensitive to radiation and visa versa

A

Anything with rapidly dividing cells is sensitive e.g. bone marrow

Resistent things:
- cerebral neurons
- muscle

44
Q

Which electrolyte disturbances associated with SCLC

A

SIADH - hyponatraemia

ALSO hypercalcaemia because of PTH

45
Q

Which type of endometrium does simple hyperplasia most similar to

A

proliferative

46
Q

Which MHC class is ONLY expressed in placenta

A

HLA-G

Remeber, C,E,G are all expressed
A and B are NOT

47
Q

When is the majority of growth hormone secreted

A

Early sleep

48
Q

Which aprt of the embryo is the origin of the primordial germ cells

A

The Yolk sac endothelium

49
Q

Where is the greater omentum derived form

A

The dorsal mesogastrium
The lesser omentum comes from the ventral mesentary

50
Q

Which electrolyte disturbance do you get with paralytic ileus

A

hypokalaemia

51
Q

Where are schiller-duval bodies found

A

Endodermal sinus tumours

52
Q

Where are signet cells found

A

krunkenburg tumours

53
Q

Where are walthard cell nests found

A

brenner tumour

54
Q

How many carbon atoms in:

oestrogen
progesterone
cortisol
aldosterone
androgen

A

18
21
21
21
19

55
Q

What is the max score in PUQE

A

15

56
Q

what are the second line drugs in hyperemesis

A

DOM

Domperidone
ondansetron
metoclopramide

57
Q

Where does the carbon base attach on ribose?

Where does phosphate attach?

A
58
Q

How many people in the UK are Rh-

A

15%

59
Q

In the horshoe kidney, what structure prevents ascent from pelvis to abdomen

A

The IMA

60
Q

angle of vagina vs horizontal whislt standing

A

60 degs

Also like the pelvis!

61
Q

which joint resists horizontal rotaiton of the pelvis

A

The sacroiliac joint

62
Q

2 most common causes of dermatitis in preg

A

Atopic dermatitis and PUPP

OC less common!

63
Q

Most common protozoan causing a zoonotic infection

A

Toxoplasmosis

64
Q

What teratogenic affect does paroxetine have

A

Congeital cardiac problems

65
Q

What does vitamin E toxicity do

A

HAEMORRHAGE

66
Q

What is teh male equivalent of the round ligament

A

The spermatic cord

They are both from the gubernaculum

67
Q

How do you monitor LMWH activity

A

Anti-Xa activity

68
Q

Timings of congenital conjuctivitis with chlamydia and gonnorrhoea

A

Chamydia - >5 days

Gonnorhoea <5 days

69
Q

How long does NAAT take for chamydia/gonorrhoea

A

C = 3 weeks

G = 2 weeks

70
Q

What type of signalling molecule is prostaglandin

A

Paracrine - acts locally outside cells

71
Q

Cuarterization of large area of tissue with appearance of smoke is called

A

Fulguration

72
Q

What is the success rate of COCP to rpevent pregnancy in typical use and perfect use

A

Typical - 9%
Perfect - 0.3%

73
Q

How is isoniazid metabolised in the liver

A

with acetylation

74
Q

Are the fibres of the internal anal sphincter circular or longitudinal

A

circular

75
Q

What is the increased cardiac output post delivery as compared to before pregnancy

A

60-80%

76
Q

What is the risk of ectopic in someone with IUD

A

1/50

77
Q

What is the rate of miscarriage in couples with baalnced transloacation

A

25-50%

78
Q

What is the precursor for nitric oxide

A

L arginine

79
Q

How are amino acids transferred from maternal to fetal circulation?

What about glucose?

A

Amino acids - Active transport

Glucose - facilitated diffusion

80
Q

Which clotting factors remain unchanged in pregnancy

A

2,5,9

81
Q

Calcitonin is secreted by which gland

A

thyroid - parafollicular cells/chief cells

82
Q

Beta haemolytic strep treatment on vaginal swab

A
83
Q

Do you give thromboprophylaxis to people with OHSS

A

Until first trimester ends

84
Q

Why is remifentanyl good in labour

A

Rapidly metabolised by tissue estrases

85
Q

How to emasure the diagonal conjugate diameter of the pelvis

A

Lower bit of PS to tip of coccys

86
Q
A

MRCOG part 1 (20 decks)

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