Reading Day 3/13 Flashcards
What is AA change in sickle cell?
valine for glutamic acid
what is rx of aplastic crisis from Parvo 19?
IVIG
name some causes of warm IgG hemolysis
CLL, SLE, lymphma and penicillin
rx of warm agglutinin hemolysis?
steroids
name some causes of cod agglutinin
EBV, waldenstroms, mycoplasma
what is most accurate test for cold agglutinin disease?
cold agglutinin titer
treatment of cold agglutinin
warm body and rituximad
treatment of HUS/TTP
plasmapheresis
what is atypical HUS?
HUS not from an infection
what is rx of atypical versus typical HUS?
atypical is acolizumab
typical is supportive
what is difference in myelofibrosis and myelodysplasia?
in fibrosis bone marrow isnt making anything…in dysplasia the marrow is hypercellular but still havepancytopenia
which of myelofibrosis/dysplasia is a leukemia precursor?
dysplasi
APML is associated with what
DIC
what should be added to chemo for ALL?
methotrexate
which chronic leukemia most frrequently transfers into acute leukemia?
CML
APML is treated with what?
All trans retinoic acid
CML is treated with what?
imatinib
what is treatment of CLL?
stage 1-3 nothing..stage 4/5 fludarabine, cyclophosphamide, and rituximab
signs of hairy cell leukemia
pancytopenia, splenomegaly, dry marrow
what is rx for hairy cell leukemia?
cladribine
what is staging of non hodgkin lymphoma?
1-1 node group
2- 2 node groups
3- both sides of diaphragm
4- widespread
what is rx of non hodgkin lymphma
cyclophosphamide, doxorubicin
vincristine
prednisone
rituximab
hodgkin has what cells?
reed sternberg cells
which of hodgkin or non hodgkin focuses around neck?
hodgkin is cervical