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Blood Banking > Reaction > Flashcards

Reaction Flashcards

1
Q

Cardiac monitorung of acute hemolytic rxns because of

A

Hypokalemia

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2
Q

Supportive care

A

ABC +/- pressors

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3
Q

Gen occurs within 2-10 days of tranx

A

Delayed hemolytic transfusion rxns

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4
Q

Usually due to senescent Ab on re exposure to foreign red cell

A

Delayed hemolytic transfusion

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5
Q

Hidtory of previous preg, trasfusion of rransplant
Usually extravascula and less severe than acute
Othe abs often rh and kidd

A

Delayed hemolytic transfusion rxns

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6
Q

Clinical presentation delayed hemolytic transfusion rxns

A

Falling hct, low grade fever, slight increase in indirect bill, spherocytes on blood smear

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7
Q

Diagnosis of delayed hemolytic transfusion rxns

A

New dat and new ab test when blood is ordered

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8
Q

Life threatening emergency

A

Anaphylactic rxns

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9
Q

Occurs with a few second to minutes following tranx

A

Anaphylactic reaction

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10
Q

Characterized by rapid onsetof anaphylaxis

A

Anaphylactic rxns

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11
Q

Can occur with all blood products but generally unseen with serum albumin, plasma protein fraction or coagulation factors

A

Anaphylactic rxns

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12
Q

Incidence of anaphylactic rxns

A

1 to 20-50,000

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13
Q

Treatment of anaphylaxis

A

Stop trans epi 0.3 ml of 1.1000 son IM
Consider IV epinephrine drip
ABC +/- pressor support

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14
Q

Presence of class specific Igg and anti IgA abs in patients who are IgA def

A

Selective IgA def is fairly common, occuring 1/300-500 people but majority of them do not develop abs

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15
Q

Similar snd occur primarily in east asian

A

Aphatoglobinemia with antihaotiglobin

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16
Q

Prevention of anaphylaxis

A

Use iga product for further tranx extra washed red cell or platelets

17
Q

Allergenic products in blood products activates ige in recipients leading to histamine release from mast cell and baso

A

Urticarial raction

18
Q

Only rxns which trans can be resumed

A

Urticaria, rxns

19
Q

If urticaria is extensive

A

Benadryl 25-50mg IV/PO

20
Q

Vare rare complication seen in immunocomp individual esp in solid tumor cancer pts oj chemo but can occur with acuteo chronic leukemia. Lymphomas, new borne with erythroblastosis fetalis and transplant pts

A

Transfusion rxns gvhd

21
Q

Different from gransplant gvhd by its effect on

A

Bone marrow. Bone marrow aplasia

22
Q

It occurs in immunocomp recipients of blood products from donor woth identical hla haplotypes

A

Transfusion rxns gvhd

23
Q

For hla they are what

A

Heterozygous

24
Q

Which donor for haplotype is

A

Homozygous

25
Q

This shared by donor and recipients thus other one is egrated by recipients because they are the only Ag seen by the host

A

Hla Ag; donor lymphocytes

26
Q

Primary cause of death in transfusion ass gvhd

A

Bone marrow aplasia

27
Q

Skin in transfusion ass gvhd

A

Swollen eythroedema and bullae for,ation

28
Q

Gi tract in transfusion ass gvhd

A

Diarrhea and abdominal cramps

29
Q

Liver in transfusion ass gvhd

A

Elevated LFT and hyprbilirubinemia

30
Q

Heme in transfusion ass gvhd

A

Bone marrow aplasia, persistent thrombocytopenia

31
Q

Implicated products

A 
Onon irradiated whole blood
Prbc
Plts
Granulocytes
Fresh non frozen plasma
32
Q

Treatment in transfusion ass gvhd

A

Poor response to standard immunosuppresive therapies, thalidomide has been tried success

33
Q

Prevention in transfusion gvhd

A

Gamma irradiation and leukoreduction of products

Avoid blood products from genetically identical donor

34
Q

New acute lung injury occurring during of whin

A

6hrs of blood product tranx

35
Q

All blood products have been implicated

May progress to ARDs

A

Transfusion related acute lung injury

36
Q

Immune non mediaed non cardiogenic pulmonary edema

A

Transfusion related acute lung injury

37
Q

Risk factor of transfusion related acute lung injury

A

No risk factors but prolonged storage of blood products, massive trans, cytokine, multiparity, thrombocytopenia, and active infection have implicated no studies

38
Q

Pathogenesis of tranx acute lung

A

Abs against HLA

Blood Banking (16 decks)

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