Reaction

Question 1

Cardiac monitorung of acute hemolytic rxns because of

Answer 1

Hypokalemia

Question 2

Supportive care

Answer 2

ABC +/- pressors

Question 3

Gen occurs within 2-10 days of tranx

Answer 3

Delayed hemolytic transfusion rxns

Question 4

Usually due to senescent Ab on re exposure to foreign red cell

Answer 4

Delayed hemolytic transfusion

Question 5

Hidtory of previous preg, trasfusion of rransplant
Usually extravascula and less severe than acute
Othe abs often rh and kidd

Answer 5

Delayed hemolytic transfusion rxns

Question 6

Clinical presentation delayed hemolytic transfusion rxns

Answer 6

Falling hct, low grade fever, slight increase in indirect bill, spherocytes on blood smear

Question 7

Diagnosis of delayed hemolytic transfusion rxns

Answer 7

New dat and new ab test when blood is ordered

Question 8

Life threatening emergency

Answer 8

Anaphylactic rxns

Question 9

Occurs with a few second to minutes following tranx

Answer 9

Anaphylactic reaction

Question 10

Characterized by rapid onsetof anaphylaxis

Answer 10

Anaphylactic rxns

Question 11

Can occur with all blood products but generally unseen with serum albumin, plasma protein fraction or coagulation factors

Answer 11

Anaphylactic rxns

Question 12

Incidence of anaphylactic rxns

Answer 12

1 to 20-50,000

Question 13

Treatment of anaphylaxis

Answer 13

Stop trans epi 0.3 ml of 1.1000 son IM
Consider IV epinephrine drip
ABC +/- pressor support

Question 14

Presence of class specific Igg and anti IgA abs in patients who are IgA def

Answer 14

Selective IgA def is fairly common, occuring 1/300-500 people but majority of them do not develop abs

Question 15

Similar snd occur primarily in east asian

Answer 15

Aphatoglobinemia with antihaotiglobin

Question 16

Prevention of anaphylaxis

Answer 16

Use iga product for further tranx extra washed red cell or platelets

Question 17

Allergenic products in blood products activates ige in recipients leading to histamine release from mast cell and baso

Answer 17

Urticarial raction

Question 18

Only rxns which trans can be resumed

Answer 18

Urticaria, rxns

Question 19

If urticaria is extensive

Answer 19

Benadryl 25-50mg IV/PO

Question 20

Vare rare complication seen in immunocomp individual esp in solid tumor cancer pts oj chemo but can occur with acuteo chronic leukemia. Lymphomas, new borne with erythroblastosis fetalis and transplant pts

Answer 20

Transfusion rxns gvhd

Question 21

Different from gransplant gvhd by its effect on

Answer 21

Bone marrow. Bone marrow aplasia

Question 22

It occurs in immunocomp recipients of blood products from donor woth identical hla haplotypes

Answer 22

Transfusion rxns gvhd

Question 23

For hla they are what

Answer 23

Heterozygous

Question 24

Which donor for haplotype is

Answer 24

Homozygous

Question 25

This shared by donor and recipients thus other one is egrated by recipients because they are the only Ag seen by the host

Answer 25

Hla Ag; donor lymphocytes

Question 26

Primary cause of death in transfusion ass gvhd

Answer 26

Bone marrow aplasia

Question 27

Skin in transfusion ass gvhd

Answer 27

Swollen eythroedema and bullae for,ation

Question 28

Gi tract in transfusion ass gvhd

Answer 28

Diarrhea and abdominal cramps

Question 29

Liver in transfusion ass gvhd

Answer 29

Elevated LFT and hyprbilirubinemia

Question 30

Heme in transfusion ass gvhd

Answer 30

Bone marrow aplasia, persistent thrombocytopenia

Question 31

Implicated products

Answer 31

``` Onon irradiated whole blood Prbc Plts Granulocytes Fresh non frozen plasma ```

Question 32

Treatment in transfusion ass gvhd

Answer 32

Poor response to standard immunosuppresive therapies, thalidomide has been tried success

Question 33

Prevention in transfusion gvhd

Answer 33

Gamma irradiation and leukoreduction of products | Avoid blood products from genetically identical donor

Question 34

New acute lung injury occurring during of whin

Answer 34

6hrs of blood product tranx

Question 35

All blood products have been implicated | May progress to ARDs

Answer 35

Transfusion related acute lung injury

Question 36

Immune non mediaed non cardiogenic pulmonary edema

Answer 36

Transfusion related acute lung injury

Question 37

Risk factor of transfusion related acute lung injury

Answer 37

No risk factors but prolonged storage of blood products, massive trans, cytokine, multiparity, thrombocytopenia, and active infection have implicated no studies

Question 38

Pathogenesis of tranx acute lung

Answer 38

Abs against HLA