Abo Blood Group Flashcards
Majority pf blood group ag are what
Immunogen
Immunogen are able to
Elicit antibody
Mediated immune response introduced as a foreign subs into a responsive host
Immunogenicity
It appears to be weak at birth but at the age of what year, this reach final strength
Antigen A. After one year, agglutinogens
Abnormal ag maybe found as
Acquired leukemia (weak A ag) and cancer
Certainly tge most immunogenic and thus all blood transfused must be matched for these ag betweem tye blood donor and the recepients
A, B, D ag
AfteD ag, yhis is the most immunogenic
K
Most important usef for blood transfusion
Abo and rhesus
The presence or absence of A, B , H Ag are controlled by
H Ag and ABO genes
The presence or absence of ABH Ag are controlled by
H gene
The presence and absence of the ABH Ag in secretion is indirectly controlled by
Se gene
Site of attachment of the immunodominat sugar
Paragloboside
Codes for an enzyme that adds n acetylgalactosamine to the terminal sufar of the H ag
A gene
Codes for an enzyme that adds D galactosyltransferase to the terminal sugar of the H Ag
B gene
It detected by using anti H antiserum derived from what
H Ag, ulex europeus
It is the foundation upon which A and B ag are built
H ag
Codes for enzyme that add a sugar to the H Ag
A and B genes
These are present at the terminal ends of the chair and confe the ABO Ag specificity
Immunodominant sugar
Secretors are controlled by
H and Se gene
The secretor gene consist of 2 alleles
Se and se gene
It is responsible for the expression of the H ag on glycoprotein structure kocated in the body secretion
Se gene
If the Se allele is inherited as SeSe or Sese the person is called
Secretor
This express soluble forms of the H ag in secretion that can then be converted to A or B Ag
Secretors
Individual who inherit the sese gene are called
Non secretors
The se allele is what
An amorph
Aka direct typing
Forward typing
Other name of forward typing
Routine typing or cell typing
Involves the determination pf unknown rbc agglutinogens by testing 2% Rbc saline suspension with known anti sera
Forward typing
Indirect typing
Backward tyoing
Other word for backward typing
Back uo typing
Determination of unknown Ab in the serum using rbc suspension of known types.
Employed as confirmatory test
Backward typing
There are two potentional precursor subs fpr ABH Ag
Type 1 and Type 2
precursor has a terminal galactose linkage to a subterminal N acetylglucosamine in a 1-3 linkage
Type 1
The sake combine in 1-4 linkage in
Type 2
ABH Ag on red cell are derived form
Type 2 chains
ABH Ag in plasma are made from both from
Type 1 and. Type 2 precursor
After the fucose is added to the type 2 chain the structure is termed
Type II H
H1 and H2 are what
Simple straight chain glycolipids
H3 and H4 are
Branched chain
Refer to genetically encoded antigen system on erythrocyte, leukocyte, pla,a and platelets
Blood group antigen
