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Blood Banking > Blood Therapy > Flashcards

Blood Therapy Flashcards

1
Q

Blood components are colllected by

A

Apheresis

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2
Q

Which donors blood is processed by

A

Ex vivo centri or apheresis machine

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3
Q

Harvest leukocys

A

Leukapheresis

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4
Q

Harvest plasma

A

Plasmapheresis

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5
Q

Harvest erythrocytes

A

Erythroapheresis

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6
Q

Harvest granulocyte

A

Granulocytapheresis

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7
Q

Harvest platelets

A

Plateletapheresis

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8
Q

Complication of apheresis

A

Sudden fluid shift
Paraesthesia
Donor discomfort
Associated cost

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9
Q

Dinors discomfort

A

Sit for 3 hrs

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10
Q

Hypotension, volume overload

A

Sudden fluid shift

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11
Q

Whole blood has shelf life of

A

35 days

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12
Q

Whole blood has what and how many preservative

And how many blood

A

70ml of citrate to 420ml blood

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13
Q

A unit of blood collected inyo an anticoagulant containing less than WHAT lecukocyte

A

5x106 whole blood, leukocyte depleted

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14
Q

Uses of whole blood

A

Rarely used
Infrequently used in massive trauma
Cardiac surgeris
Post operative bleeding unresponsuve to standard replacement therapy
Paedriatic, practice mostly for neonatal exchange transfusion or paedriatic surgery

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15
Q

Produced by removing 150-200ml of citrated plasma from a unit of whole blood

A

Packed rbc

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16
Q

Packed rbc stored at what temp

A

1-6deg

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17
Q

Packed rbc is tored in specific temp to maintain what

A

Viability of the red cell and

Prevent growth of bacteria

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18
Q

Cpd

A

21 days

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19
Q

Cpda

A

35

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20
Q

Sag m

A

42

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21
Q

Adsol nutricel optisol

A

42

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22
Q

It is a anticoagulant

A

Citrate

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23
Q

Serves as buffer

A

Phosphate

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24
Q

Red cell energy sources

A

Dextrose

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25
Q

Allows rbc to synthesuze atp which extends the storage from 21-35 days

A

Adenine

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26
Q

Adsol is composed of what

A

As1 adenine, glucose, nacl, mannitol

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27
Q

As 3 composed of

A

Nutricel glucose, adenine citrate, phosphate, nacl

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28
Q

As 5

A

Optisol adenine, nacl, mannitol

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29
Q

Packed rbc

A 
Leukoreduced
Irradiated
Frozen thawed
Saline washed
Cmv neg
Ag neg
Sickle neg
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30
Q

Red cell component prepared by remiving a proportion of the plasma form leukocyte depleted whole blood or leuco depleting plasma reduced rbc

A

Leukoreduced

31
Q

Non lr rbc containdd

A

1-3 x 109 wbc

32
Q

Lr contained

A
33
Q

Certain complication of prbc are likely due

A 
Leukocytes ex 
Hla
Alloimmunization against class I ag
Febrile reaction
Cmv infection
34
Q

By leukoreduction chances of febrile reaction can be reduced es

A

Alloimunized from pregnancy
Risk for hla
Alloimmunization from blood transfusion

35
Q

Leukoreduced indications are

A 
Chronically transfused pt
Potential transplant recipients
Patients w transplant
Patient w previous febrile non hemolytic transfusiin reaction
Cmv seroneg at risk pt
36
Q

Has been considered or omplemented because of some anticipated benefits including

A

Dec transmission of creutz feldt jakob dse
Leukocyte induced immunomodulation
Dec postoperative mortality

37
Q

Is the direction in whic transfusion medicine has gone

A

Universal leukoreduction

38
Q

Prbc units are exposed to what

A

Gamma irradiation 2,500 c6y

39
Q

Prbc units are exposed to gamma to damage donor wbc dna

A

Irradiated

40
Q

Irradiated usually performed in

A

Cesium 137 blood irradiators

41
Q

Prevent a cellular immune proliferative response to the recipients tissue

A

Irradiated

42
Q

Indications of irradiated

A 
Units from blood relatives
Allo o auto hoc transplant recipients
Intrauterine transfusion
Neonates undergoing exchange transfusion
Hodgkins
Cellular immune def
Solid organ transplant
Gvhd
43
Q

Designed machine are used to washed the rbc which are then suspended in sterile saline

A

Washed red cell micriaggregate free blood

44
Q

Sakine washing removes

A

Residual plasma 98% preduced cocn of leukocytes, plts, and cellular debris

45
Q

Can carried out at any time during the shelf life of a unit of blood

A

Washed red cell microaggregate free blood

46
Q

Washed red cell usually have how many hct and volume

A

70-80% and volume of 180ml

47
Q

One donated unit can help multiple patients

A

Conserve resources

Optimal method for transfusing large amount of specific components

48
Q

Indication of washed red cell

A

Patient with recurrent , severe allergic or febrile reaction to red cell
Severely iga
Microaggregate red cell usd to prevent reaction to leukocyte and plt ag

49
Q

Used to prevent reaction to leukocyte and platelet ag

A

Microaggregate free blood

50
Q

Cmv begative indications

A 
All neonates
Intrauterine transfusion 
High risk lung transplant
Allogenic stem cell transplant
Digeorge syndrome
51
Q

Freesing to preserve rare rbc units

A

Frozen rbc

52
Q

Rbc is frozen in

A

40% glycerol

53
Q

Frozen rbc is stored at what mo in how many yrs

A

-80 for 10yrs

54
Q

Changes during storage of blood

A

Blood can be stored for 42 days is a mized blessing the obviosu advantage is the inc availability of blood
Numerous changes occur during storage and affect tge quality of transfusion

55
Q

The storage temp of 1-6 deg stimulate what

A

Sodium potassium pumo and rbc lose k and gain Na

56
Q

The osmotic fragility of rbc is what during

A

Inc during storage and cell undergo lysis which inc plasma hb levels

57
Q

Rbc conc of atp and 2,3 dpg is what

A

Dec during storage

58
Q

Measure hb and hct when substantial blood loss ir any indication of organ ischemia occurs

A

Monitoring for transfusion indication

59
Q

Rbc shoudl be administered when

A

Hb conc is low less than 6g/dl

60
Q

Rabc is usually unnecessary when

A

Hb conc is more than 10g/dl

61
Q

Dermimation of whether intermediate hb conc 6-10g/dl justidy or require rbc transfusion

A

Monitoring transfusion indiation

62
Q

Monitoring transfusion indication is based on

A

On going indication of organ ischemia
Potential or actual ongoing bleeding
Pt intravascular volume status
Pt risk factor for complication of inadequate oxygenation

63
Q

Transfusion whuch involve 10% blood volume replaced in 10mins or less

A

Put forward by diff group

64
Q

Any transfusion in shich 1 unit of blood is given in 5mins

A

Put forward by diff group

65
Q

Indcation of massive transfuison

A

Trauma crush injury
Orthopaedic surgery
Kiver surgery

66
Q

The decision to start on the physiological state of pt

A

Evidence of amout ob blood loss

Potential for ongoing hemorrhage

67
Q

The buffy coat contains high conc of

A

White cell and plts

68
Q

Buffy coat that are not used to male plt conc are used for

A

Granulocyte production

69
Q

This technique can be also employed for collecting granulocyte

A

Apheresis

70
Q

Granulocyte are stored at

A

22+2 dg without agitation

71
Q

50ml om volume a haemometer 45% contains

A

1-2x109 white cells
90x109 plts
9.5g hb

72
Q

A dose of ten packs for adults

A

Granulocyte transfusion dosing

73
Q

Granulocye transfusion in children less than 50kg

A

10-20ml per kg less than 50kg to a max of 10 packs

74
Q

Granulocyte transfusion in less than 30kh shoudl receive

A

10-20ml per kh max of 2 packs

Blood Banking (16 decks)

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