Blood Therapy Flashcards
1
Q
Blood components are colllected by
A
Apheresis
2
Q
Which donors blood is processed by
A
Ex vivo centri or apheresis machine
3
Q
Harvest leukocys
A
Leukapheresis
4
Q
Harvest plasma
A
Plasmapheresis
5
Q
Harvest erythrocytes
A
Erythroapheresis
6
Q
Harvest granulocyte
A
Granulocytapheresis
7
Q
Harvest platelets
A
Plateletapheresis
8
Q
Complication of apheresis
A
Sudden fluid shift
Paraesthesia
Donor discomfort
Associated cost
9
Q
Dinors discomfort
A
Sit for 3 hrs
10
Q
Hypotension, volume overload
A
Sudden fluid shift
11
Q
Whole blood has shelf life of
A
35 days
12
Q
Whole blood has what and how many preservative
And how many blood
A
70ml of citrate to 420ml blood
13
Q
A unit of blood collected inyo an anticoagulant containing less than WHAT lecukocyte
A
5x106 whole blood, leukocyte depleted
14
Q
Uses of whole blood
A
Rarely used
Infrequently used in massive trauma
Cardiac surgeris
Post operative bleeding unresponsuve to standard replacement therapy
Paedriatic, practice mostly for neonatal exchange transfusion or paedriatic surgery
15
Q
Produced by removing 150-200ml of citrated plasma from a unit of whole blood
A
Packed rbc
16
Q
Packed rbc stored at what temp
A
1-6deg
17
Q
Packed rbc is tored in specific temp to maintain what
A
Viability of the red cell and
Prevent growth of bacteria
18
Q
Cpd
A
21 days
19
Q
Cpda
A
35
20
Q
Sag m
A
42
21
Q
Adsol nutricel optisol
A
42
22
Q
It is a anticoagulant
A
Citrate
23
Q
Serves as buffer
A
Phosphate
24
Q
Red cell energy sources
A
Dextrose
25
Allows rbc to synthesuze atp which extends the storage from 21-35 days
Adenine
26
Adsol is composed of what
As1 adenine, glucose, nacl, mannitol
27
As 3 composed of
Nutricel glucose, adenine citrate, phosphate, nacl
28
As 5
Optisol adenine, nacl, mannitol
29
Packed rbc
```
Leukoreduced
Irradiated
Frozen thawed
Saline washed
Cmv neg
Ag neg
Sickle neg
```
30
Red cell component prepared by remiving a proportion of the plasma form leukocyte depleted whole blood or leuco depleting plasma reduced rbc
Leukoreduced
31
Non lr rbc containdd
1-3 x 109 wbc
32
Lr contained
33
Certain complication of prbc are likely due
```
Leukocytes ex
Hla
Alloimmunization against class I ag
Febrile reaction
Cmv infection
```
34
By leukoreduction chances of febrile reaction can be reduced es
Alloimunized from pregnancy
Risk for hla
Alloimmunization from blood transfusion
35
Leukoreduced indications are
```
Chronically transfused pt
Potential transplant recipients
Patients w transplant
Patient w previous febrile non hemolytic transfusiin reaction
Cmv seroneg at risk pt
```
36
Has been considered or omplemented because of some anticipated benefits including
Dec transmission of creutz feldt jakob dse
Leukocyte induced immunomodulation
Dec postoperative mortality
37
Is the direction in whic transfusion medicine has gone
Universal leukoreduction
38
Prbc units are exposed to what
Gamma irradiation 2,500 c6y
39
Prbc units are exposed to gamma to damage donor wbc dna
Irradiated
40
Irradiated usually performed in
Cesium 137 blood irradiators
41
Prevent a cellular immune proliferative response to the recipients tissue
Irradiated
42
Indications of irradiated
```
Units from blood relatives
Allo o auto hoc transplant recipients
Intrauterine transfusion
Neonates undergoing exchange transfusion
Hodgkins
Cellular immune def
Solid organ transplant
Gvhd
```
43
Designed machine are used to washed the rbc which are then suspended in sterile saline
Washed red cell micriaggregate free blood
44
Sakine washing removes
Residual plasma 98% preduced cocn of leukocytes, plts, and cellular debris
45
Can carried out at any time during the shelf life of a unit of blood
Washed red cell microaggregate free blood
46
Washed red cell usually have how many hct and volume
70-80% and volume of 180ml
47
One donated unit can help multiple patients
Conserve resources
| Optimal method for transfusing large amount of specific components
48
Indication of washed red cell
Patient with recurrent , severe allergic or febrile reaction to red cell
Severely iga
Microaggregate red cell usd to prevent reaction to leukocyte and plt ag
49
Used to prevent reaction to leukocyte and platelet ag
Microaggregate free blood
50
Cmv begative indications
```
All neonates
Intrauterine transfusion
High risk lung transplant
Allogenic stem cell transplant
Digeorge syndrome
```
51
Freesing to preserve rare rbc units
Frozen rbc
52
Rbc is frozen in
40% glycerol
53
Frozen rbc is stored at what mo in how many yrs
-80 for 10yrs
54
Changes during storage of blood
Blood can be stored for 42 days is a mized blessing the obviosu advantage is the inc availability of blood
Numerous changes occur during storage and affect tge quality of transfusion
55
The storage temp of 1-6 deg stimulate what
Sodium potassium pumo and rbc lose k and gain Na
56
The osmotic fragility of rbc is what during
Inc during storage and cell undergo lysis which inc plasma hb levels
57
Rbc conc of atp and 2,3 dpg is what
Dec during storage
58
Measure hb and hct when substantial blood loss ir any indication of organ ischemia occurs
Monitoring for transfusion indication
59
Rbc shoudl be administered when
Hb conc is low less than 6g/dl
60
Rabc is usually unnecessary when
Hb conc is more than 10g/dl
61
Dermimation of whether intermediate hb conc 6-10g/dl justidy or require rbc transfusion
Monitoring transfusion indiation
62
Monitoring transfusion indication is based on
On going indication of organ ischemia
Potential or actual ongoing bleeding
Pt intravascular volume status
Pt risk factor for complication of inadequate oxygenation
63
Transfusion whuch involve 10% blood volume replaced in 10mins or less
Put forward by diff group
64
Any transfusion in shich 1 unit of blood is given in 5mins
Put forward by diff group
65
Indcation of massive transfuison
Trauma crush injury
Orthopaedic surgery
Kiver surgery
66
The decision to start on the physiological state of pt
Evidence of amout ob blood loss
| Potential for ongoing hemorrhage
67
The buffy coat contains high conc of
White cell and plts
68
Buffy coat that are not used to male plt conc are used for
Granulocyte production
69
This technique can be also employed for collecting granulocyte
Apheresis
70
Granulocyte are stored at
22+2 dg without agitation
71
50ml om volume a haemometer 45% contains
1-2x109 white cells
90x109 plts
9.5g hb
72
A dose of ten packs for adults
Granulocyte transfusion dosing
73
Granulocye transfusion in children less than 50kg
10-20ml per kg less than 50kg to a max of 10 packs
74
Granulocyte transfusion in less than 30kh shoudl receive
10-20ml per kh max of 2 packs
