Rats Biology/models

Question 1

Effects of continuous light on female rats

Answer 1

Persistent estrus and cystic follicles in the ovaries, without formation of CL

Question 2

Chronic exposure to low-intensity light during dark cycle leads to:

Answer 2

Earlier vaginal opening and ovarian atrophy

Question 3

Caloric restriction may affect reproduction how?

Answer 3

Cessation of estrous cycles and delayed sexual maturation

Question 4

High ambient temperatures may affect male breeding mice how?

Answer 4

Male infertility from irreversible degeneration of the seminiferous epithelium

Question 5

Answer 5

Exorbital gland from a mature male rat. Note megalokarya and polykarya of acinar epithelial cells

Question 6

Induced pulmonary granulomatous vasculitis

Answer 6

IV injection of glucan

Question 7

Induced cardiotoxicity/heart failure

Answer 7

IV doxorubicin

Question 8

Bacteria causing dental caries

Answer 8

Streptobacillus lactobacilli and S. salivarius

Question 9

Diet induced fatty liver/cirrhosis

Answer 9

Deficient in choline, methionine, vitamin B-12, and folic acid

High in fat

Wistar, Fisher, or CRCD rats

Question 10

Induction of duodenal ulcer

Answer 10

PO or SQ cysteamine (2-aminoethanethiol)

Question 11

Waterhouse-Friderichsen syndrome (adrenal apoplexy) induction

Answer 11

IV injection of acrylonitrile

Question 12

MPS induction

Answer 12

Suramin

Question 13

Malignant Fibrous Histiocytoma induction

Answer 13

SQ or periosseous injection of 4-HAQO

Question 14

Osterosarcoma induction

Answer 14

Intratibial injection of Maloney Sarcoma virus

Question 15

Rheumatoid arthritis induction in Lewis rat

Answer 15

SQ injection of M. butryicum

Question 16

Induction of osteomyelitis

Answer 16

Injection of S. aureus in traumatized rat tibiae

Question 17

Chronic pulmonary hypertension induction

Answer 17

Exposure to hypoxic atmosphere for 4 weeks

Question 18

Inuduction of pulmonary alveolar lipo-proteinosis

Answer 18

Inhalation or exposure to silica dust

Question 19

Squamous cell carcinoma inudction in MRC rats

Answer 19

NHMI in drinking water

Question 20

Induction of struvite urolithiasis

Answer 20

Implantation of zinc disks in bladder followed by innoculation with P. mirabilis

Question 21

Optic disc swelling induction

Answer 21

IP injection of IDPN

Question 22

Immune mediated polyneuropathy

Answer 22

Australian albino Wistar rats

Injection of E. coli LPS