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BB 3rd Edition > Mouse basic biology/history > Flashcards

Mouse basic biology/history Flashcards

1
Q

Thymic maturation

A

Involutes around 35-80 days of ages

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2
Q

MALT

A

Contains more lymphoid cells and produces greater amount of immunoglobulin than both the spleen and LN

Peyer’s patches, cecal lymphoid tissue, lymphoid tissue in upper and lower respiratory system, as well as respiratory and genitourinary system

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3
Q

Vertebral formula - mouse

A

C7T13L6S4C28

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4
Q

Mammary glands - mouse

A

Five pairs - three cervicothoracic, two inguinoabdominal

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5
Q

Estrous cycle - mouse

A

Polyestrous, cycles every 4-5 days

Proestrus/estrus - active epithelial growth culminates in ovulation

Metestrus - degenerative epithelial changes

Diestrus - Quiescence/slow growth

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6
Q

Sex glands - male mouse

A

Ampullary gland, seminal vesicle, anterior/ventral/dorsal prostate, bulbourethral gland, preputial glands

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7
Q

Whitten effect

A

Re-entry into estrus synchronized in group housed females by exposure to pheromones in the male mouse urine. Within 3 days.

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8
Q

Bruce effect

A

Pheromones from a strange male mouse may prevent implantation or pseudopregnancy in recently bred females

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9
Q

Copulatory plug

A

Vesicular and coagulating gland secretions

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10
Q

Fertilization of ova

A

Can be fertilized for 10-12h after ovulation, takes place in the ampulla or upper portion of the oviduct

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11
Q

MUP20

A

Male-specific major urinary protein - rewarding and attractive to females, intermale agression/area avoidance

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12
Q

Male lacrimal protein ESP1

A

Lordosis in female mouse

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13
Q

Exocrine gland secreting peptide 22 (ESP22)

A

Inhibitory on older adult male mating behavior

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14
Q

Humoral immunity - mice

A

The majority of antibody is transferred through colostrum

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15
Q

Releaser pheromones

A

Elicit an immediate behavioral response

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16
Q

Primer pheromone

A

Mediate a slowly developing and longer-lasting endocrine response

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17
Q

Singaler pheromones

A

Convey individual or group indentity

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18
Q

Pheromone sensory organs

A

Vomeronasal organ, olfactory epithelium, septal organ of Masera, Gruenberg ganglion

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19
Q

Mups

A

Murine urinary proteins, chromosome 4, lipocalins, synthesized in liver

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20
Q

Kairomones

A

Chemical signals between species

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21
Q

Mus m 1

A

(Ag 1 or MA1), encoded by Mup 17 gene, potent allergen

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22
Q

Vandenbergh effect

A

Acceleration of puberty in juvenile females in response to male urine

23
Q

Lee-Boot

A

Group housed females that are isolated from males, suppression of estrus cyclicity

24
Q

Mouse puberty

A

28-49 days

25
Q

Compensation for high metabolic rate

A

high alveolar PO2; a rapid respiratory rate;
a short air passage; a moderately high erythrocyte (RBC)
concentration; high RBC hemoglobin and carbonic
anhydrase concentrations; a high blood O2 capacity; a
slight shift in the O2-dissociation curve, enabling O2 to
be unloaded in the tissue capillaries at a high PO2; a more
pronounced Bohr effect, i.e., the hemoglobin affinity for
O2 with changes in pH is more pronounced; a high capillary
density; and a high blood sugar concentration.

26
Q

Altered Schaedler’s Flora

A

Four originals (two lactobacilli, Bacteroides distasonis, and EOS fusiform bacteria), a spiral-shaped bacterium, and three new fusiform EOS bacteria

27
Q

Periarteriolar sheath in mice (spleen)

A

Mostly CD4+ and CD8+ T cells and lymph follicles (germinal centers)

28
Q

Mouse dental formula

A

One incisor and 3 molars for each quadrant

29
Q

Mating - hormonal changes

A

When vagina/cervix are stimulated, prolactin is released from the anterior pituitary to enable CL to secrete progesteron

If fertilization has occured, placenta will take over production at 13 days

30
Q

Milk production - mouse

A

Milk production increases up to 12 days post-partum and then declines until weaning at 21 days

Majority of antibody is tranferred through colostrum

.

31
Q

Primary lymphoid tissues

A

Thymus and bone marrow

32
Q

Secondary lymphoid tissues

A

Lymph nodes, spleen, and intestinal Peyer’s patches

33
Q

Tertiary Lymphoid tissues

A

Form in other solid organs in response to an insult or microbial exposure, e.g. - GALT, BALT

34
Q

Innate immune system

A

Responds rapidly to antigen insult via recognition of PAMPs (LPS etc.)

Monocytes/macrophages, granulocytes, and dendritic cells, innate-like lymphocyte populations (ILL) - NK cells

35
Q

Adaptive immune system

A

T and B lymphocytes

Highly antigen-specific receptor that has arisen through gene rearrangement

36
Q

IgA

A

Serum IgA levels are low, but is the highest produced in mice

Production occurs in plasma cells lodged in the laminal propria of mucosal tissues

37
Q

Cytokines

A

Secreted signaling molecules involved in cell-cell communication

interleukins, TNFs, interferons, GM-CSF

Secretion occurs in response to recognition of antigen via PRR or TCR

38
Q

Chemokines

A

Regulate cell-trafficking to sites of antigen encounter and facilitate cell-to-cell contact by acting as chemoattractants

39
Q

Melanosis B6 mouse

A

heart valves, splenic capsule and trabeculae, meninges, cerebral vessels, Hardarian glands, and parathyroid

40
Q

Paneth cells

A

Occupy crypt bases in the small intestines

Specialized enterocytes have prominent eosinophilic cytoplasmic granules

41
Q

Mouse rectum

A

Short (1-2mm), not enveloped in serosa

Prone to rectal prolapse

42
Q

Neonatal mouse bowel

A

Small intestinal enterocytes are vacuolated and may contain eosinophilic inclusions due to precense of apical-tubular system

Very shallow crypts of Leiberkuhn

Intestinal cell turnover kinetics are slow, making neonates highly suceptible to cytolytic viruses

43
Q

Mouse placentation

A

Hemochorial

44
Q

MHC

A

Chromosome 17

Causes rapid rejection of grafts that display foreign H2 antigens

45
Q
A

Exorbital lacrimal gland

46
Q
A

Exorbital lacrimal gland

47
Q
A

Hardarian gland

48
Q
A

Male submandibular salivary gland

Columnar epithelium w/ basal nuclei

49
Q
A

Female submandibular salivary gland

Cuboidal epithelium w/ central nuclei

50
Q
A

Male kidney - mouse

51
Q
A

Female kidney - mouse

52
Q

Hoover-Drichamer

A

Precense of urine from a foreign pregnant or lactating female prolongs estrus

53
Q

Lee-Boot

A

When female mice are housed together in small groups (4-5) without a male present, there is an increase in the incidence of spontaneous pseudopregnancy

54
Q

Vandenbergh

A

Accidental exposure of prepubescent female mice to male urine accelerates puberty

BB 3rd Edition (19 decks)

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