Other dz Flashcards
Amyloidosis
Deposition of insoluble (polymerized), mis-folded amyloid protein fibrils
Primary amyloidosis is naturally occuring in mice - associated with deposition of immunoglobulin light chains
Secondary amyloidosis - antecedent, chronic inflammation
Common in aging mice - A, SJL
Resistant - BALB/c, C3H.
Deposition: hepatic portal triads, periarteriolar lymphoid sheaths in spleen, renal glomeruli and interstitium, internal lamine propria, myocardium, nasal submucosa, pulmonary alveolar septa, gonads, endocrine tissues, great vessels
Reactive amyloid A amyloidosis
Serum AA protein forms deposits in animals that experience chronic inflammation
AA amyloid fibrils are abnormal Beta-sheet-rich forms of the serum precursor SAA
May be transmissble in mice
Soft tissue mineralization
Myocardium of the left ventricle, epicardium, skeletal muscle, kidneys, arteries, lungs (cornea, tongue)
Common in some strains: BALB/c, C3H, and DBA
PXE mice
PXE mice
Pseudoxanthoma elasticum (PXE)
Heritable ectopic mineralization disorder in humans
Caused by mutations in ABCC6 gene
Knockout Abcc6-/- mice - mineralization of vibrissae dermal sheather
Reye’s-like syndrome
Hepatic lesions in SCID mice infected with MAdV-1
Hyperventilate, lethargic, comatose
Vitamin A deficiency
Tremors, diarrhea, rough hair coat, keratitis, poor growth, abscesses, hemorrhages, and sterility or abortions
Vitamin E deficiency
Convulsions, heart failure, muscular dystrophy, hyaline degeneration
Models - lack alpha-tocopherol transfer protein, Ttpa-/- mice - neuronal degenration, ataxia, age-related behavioral defects
Vitamin B deficiency
Nonspecific signs - alopecia, decreased feed consumption, poor growth, poor reproduction and lactation
Choline deficiency
Fatty livers, nodular hepatic hyperplasia, myocardial lesions, decreased consumption, decreased viability of litters
Folic acid deficiency
Decreases in red and white blood cell counts and disappearance of megakaryocytes and nucleated cells from spleen
Thiamin deficiency
Neurological signs - violent convulsions, cartwheel movements, decreased food consumption
Gulo-/- mouse
Gulonolactone oxidase knockout mouse
Postpartum ileus
Acute intestinal pseudo-obstruction
B6
Primiparous females in 2nd week of lactation
Atrial thrombosis
Rare, high prevelance in RFM mice
More common in aged mice with kidney disease and amyloidosis
Left atrium and auricle
Acidophilic crystalline pneumonia
C57BL, 129S4/SvJae, Swiss mice
Upper respiratory tract, stomach, gall bladder, bone marrow (hyalinosis)
