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Pharmacology > RAT20 > Flashcards

RAT20 Flashcards

1
Q

Methylnaltrexone, Alvimopan, Naloxegol

A

peripheral mu antagonist; constipation/vomiting from narcotics

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2
Q

Lacosamide

A

Enhances slow inactivation of Na+ channel, modulates CRMP-2 to prevent aberrant formation of neural cxns; partial seizure prevention, neuropathic pain

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3
Q

Buprenorphine

A

mu receptor agonist, occupies mu receptor in reward pathway; narcotic abstinence

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4
Q

Lamotrigine

A

Stabilize inactivated Na+ channel; GTPC + partial and absence seizures, neuropathic pain

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5
Q

Codeine

A

PARTIAL mu receptor agonist; cough, SE: RNV

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6
Q

Clonidine

A

a2 agonist, reduces firing of CNS neurons under narcotic influence; narcotic withdrawal SE: sedation

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7
Q

Naloxone

A

opioid receptor (mu + kappa + delta) antagonist; narcotic overdose

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8
Q

Benzocaine

A

topical LA that blocks open and inactivated Na+ channel, barely soluble in water; mucosa, skin, patch

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9
Q

Celecoxib

A

reversible inhibitor, relatively COX2 selective; pain, inflammation, OA, SE: thromboembolitic events

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10
Q

Aspirin

A

irreversible, non-selective inhibitor of cyclooxygenase; pain, fever, inflammation; SE: bleeding, peptic ulcer

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11
Q

Oxycodone, Hydrocodone

A

mu receptor agonist; postoperative outpatient analgesia, chronic pain, cough, SE: RNV

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12
Q

Thiopental, Propofol, Etomidate

A

Increase GABAa receptor fxn, GA (contraindicated in hypovolemia and porphryias/ reduces ICP and causes pain/ stable hemodynamics but causes myoclonus)

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13
Q

Vigabatrin

A

GABA aminotransferase inhibitor; GTPC + partial seizures

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14
Q

Ibuprofen, naproxen, indomethacin, sulindac, diclofenac

A

Reversible, non-selective inhibitor of cyclooxygenase; OA, gout attack

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15
Q

Meloxicam

A

reversible, somewhat COX2 selective inhibitor; pain, inflammation, OA, SE: bleeding, peptic ulcer

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16
Q

Acetaminophen

A

reversible inhibitor of COX2 in CNS; pain, fever, OA, but no inflammatory, SE: acute hepatitis

17
Q

Clonazepam, Phenobarbital

A

Increase GABAa receptor amplitude/duration of IPSP; GTPC + partial seizures

18
Q

Lidocaine, Bupivicaine

A

reversibly blocks open and inactivated Na+ channel; LA for intra/post operative analgesia

19
Q

Fentanyl, Sufentanil

A

mu receptor agonists, highly lipophilic; pre/intra operative analgesia, SE: RNV

20
Q

Ethosuximide

A

Inhibition of low threshold Ca++, prevent discharge of thalamic relay neurons; absence seizures

21
Q

Pentazocine

A

kappa receptor agonist, partial mu receptor agonist; analgesia without euphoria

22
Q

Methadone

A

mu receptor agonist, occupies mu receptor in reward pathway; narcotic abstinence, chronic pain, SE: RNV

23
Q

Alprostadil

A

synthetic PGE1, causes vasodilation; ED, PDA keep open

24
Q

Loperamide

A

peripheral mu agonist; diarrhea

25
Q

Morphine

A

mu receptor agonist; postoperative/end of life analgesia in hospital, SE: RNV

26
Q

Phenytoin, Carbamazepine, Zonisamide, Topiramate

A

Stabilize inactivated Na+ channel; GTPC + partial seizures, C,T: neuropathic pain

27
Q

Tramodol

A

Partial mu receptor agonist + NE/5-HT transport; mild pain

28
Q

Perampanel

A

Non-competitive antagonist of AMPA glutamate receptor; GTPC + partial seizures

29
Q

Tetracaine

A

topical LA that blocks open and inactivated Na+ channel, ester; cornea + longest procedures

30
Q

Gabapentin, Pregablin

A

Opposes synaptic adhesion, Bind y regulatory subunit of voltage-gated calcium channels, reduce number of excitatory synapses; neuropathic pain and seizures

31
Q

Valproate

A

Stabilize inactivated state of Na+ channel, inhibits Ca++, inhibits HDAC; ALL seizures BUT most teratogenic

32
Q

Heroin

A

mu receptor agonist, DA reward pathway activation, SE: RNV

33
Q

Sevoflurane, Desflurane, Isoflurane

A

GA, increase GABAa receptor fxn; inhalation anesthetic

34
Q

Tiagabine

A

GABA transport inhibitor; GTPC + partial seizures

35
Q

Nitrous oxide

A

NMDA receptor antagonist; mild analgesic effect, used to reduce requirement of other inhalational GA

36
Q

Midazolam, Diazepam

A

Benzo; sedation, anxiolysis, amnesia before/during surgery

37
Q

Levetiracetam

A

Binds SV2A synpatic vesicle protein, modulates excessive NT release; GTPC + partial seizures

38
Q

Ketamine

A

NMDA channel blocker; dissociative anesthesia causes hallucinations and delirium

Pharmacology (20 decks)

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