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Pharmacology > Chemo > Flashcards

Chemo Flashcards

1
Q

Docetaxel

A

microtubule inhibitor from pacific yew tree, ovarian/breast, lung, head and neck cancer, BM + peripheral neuropathy + skin eruptions + bronchospasms

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2
Q

Cetuximab

A

monoclonal Ab against EGFR- only useful on wild-type KRAS, head and neck cancer + colorectal cancer

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3
Q

Vinorelbine

A

microtubule inhibitor in M phase, lung/breast cancer, BM toxicity + constipation

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4
Q

Etoposide

A

topoisomerase 2 inhibitor + promotes strand breaks, testicular cancer + SCLC + lymphomas/childhood tumors, classical + alopecia + secondary leukemia

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5
Q

Everolimus

A

mTOR inhibitor by blocking T-cell activation, renal cell carcinoma + neuroendocrine tumors + breast cancer

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6
Q

Trastuzumab

A

monoclonal Ab against Her-2 causes internalization and cell lysis, Her2-neu pos breast cancer, infusion rxns + cardiotoxicity

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7
Q

Imatinib

A

inhibits v-ABL and c-Kit TK, CML, N/V + diarrhea + edema

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8
Q

Cyclophosphamide

A

alkylating agent, pro-drug metabolized in liver, haemorrrhagic cystitis, BM suppression

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9
Q

Trifluridine/Tiparicil (Lonsurf®)

A

antimetabolite- replaces dTTP incorporated into DNA + inhibits thymidylate synthetase to deplete dTMP

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10
Q

Vinblastine

A

solid tumor version of vincristine

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11
Q

Tamoxifen

A

hormonal- estrogen antagonist, breast cancer, hot flashes + vasodilation + edema + nausea

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12
Q

Daunorubicin

A

Doxorubicin analog for AML, classic + alopecia + cardiac toxicity

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13
Q

Anastrozole

A

hormonal- aromatase inhibitor block extra-adrenal synthesis of estradiol, breast cancer, hot flashes

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14
Q

Aprepitant

A

antiemetic- targets NK1 receptor and blocks substance P activity @ chemoreceptor trigger zone

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15
Q

Bevacizumab

A

monoclonal Ab against VEGF- blocks angiogenesis, hypertension + proteinuria + poor wound healing

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16
Q

Rituximab

A

monoclonal Ab against CD20 on B cells, B cell leukemia + lymphomas, infusion rxns (cytokine storm) + tumor lysis syndrome

17
Q

Irinotecan

A

topoisomerase 1 inhibitor + promotes strand breaks, colon cancer, classical

18
Q

Cisplatin

A

alkylating agent, 1st gen via platinum electrode, nephrotoxicity, peripheral neuropathies, mucositis, diarrhea,

19
Q

Carboplatin

A

alkylating agent, 2nd gen, hematopoietic toxicity (primarily), mucositis, diarrhea

20
Q

Capecitabine

A

antimetabolite- 5-FU oral form, converted to 5-FU in the liver

21
Q

Lapatinib

A

EGFR + Her-2/neu inhibitor, Her-2 pos metastatic breast cancer, rash + diarrhea

22
Q

Leuprolide

A

hormonal- GnRH receptor agonist, prostate cancer, edema + nausea + vomiting + gynaecomastia

23
Q

Letrozole

A

hormonal- aromatase inhibitor block extra-adrenal synthesis of estradiol, breast cancer, hot flashes

24
Q

Paclitaxel

A

microtubule inhibitor from pacific yew tree, ovarian/breast cancer, BM + peripheral neuropathy + skin eruptions + bronchospasms

25
Q

Ondansetron

A

antiemetic- blocks 5-HT-evoked firing on GI tract vagla endings and chemoreceptor trigger zone

26
Q

Topotecan

A

topoisomerase 1 inhibitor + promotes strand breaks, lung/ovarian cancer, classical

27
Q

Flutamide

A

hormonal- androgen receptor antagonist, prostate cancer, hot flashes + galactorrhea + impotence + vomiting + diarrhea

28
Q

Vincristine

A

microtubule inhibitor in M phase, leukemia + lymphoma + breast cancer, footdrop and constipation

29
Q

Doxorubicin

A

antibiotic, DNA intercalators- intercalate + free radicals + inhibit topoisomerase 2, breast cancer + lymphomas + sarcomas, classic + alopecia + cardiac toxicity

30
Q

Methotraxate

A

antimetabolite- depletion of folate and stops purine/thymidylate synthesis, childhood leukemia/lymphomas, breast cancer, BM, hepatic, renal impairment mucositis, diarrhea

31
Q

Oxaliplatin

A

alkylating agent, neurological toxicity, mucositis, diarrhea

32
Q

5-FU

A

antimetabolite- 5-FU incorporated into RNA + 5-FdUMP inhibits thymidylate synthase, colon/breast cancer, classic toxicities + hand-foot syndrome

33
Q

Gemcitabine

A

antimetabolite- DNA chain terminator via cytidine replacement + inhibits ribonucleotide reductase (can’t make dNTP), pancreatic cancer + NSCLC, flu-like syndrome

34
Q

Erlotinib/Gefitinib

A

EGFR inhibitor + especially if it has activating EGFR mutation, NSCLC + pancreatic cancer, rash + diarrhea + fatigue + interstitial lung disease

Pharmacology (20 decks)

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