Chemo

Question 1

Docetaxel

Answer 1

microtubule inhibitor from pacific yew tree, ovarian/breast, lung, head and neck cancer, BM + peripheral neuropathy + skin eruptions + bronchospasms

Question 2

Cetuximab

Answer 2

monoclonal Ab against EGFR- only useful on wild-type KRAS, head and neck cancer + colorectal cancer

Question 3

Vinorelbine

Answer 3

microtubule inhibitor in M phase, lung/breast cancer, BM toxicity + constipation

Question 4

Etoposide

Answer 4

topoisomerase 2 inhibitor + promotes strand breaks, testicular cancer + SCLC + lymphomas/childhood tumors, classical + alopecia + secondary leukemia

Question 5

Everolimus

Answer 5

mTOR inhibitor by blocking T-cell activation, renal cell carcinoma + neuroendocrine tumors + breast cancer

Question 6

Trastuzumab

Answer 6

monoclonal Ab against Her-2 causes internalization and cell lysis, Her2-neu pos breast cancer, infusion rxns + cardiotoxicity

Question 7

Imatinib

Answer 7

inhibits v-ABL and c-Kit TK, CML, N/V + diarrhea + edema

Question 8

Cyclophosphamide

Answer 8

alkylating agent, pro-drug metabolized in liver, haemorrrhagic cystitis, BM suppression

Question 9

Trifluridine/Tiparicil (Lonsurf®)

Answer 9

antimetabolite- replaces dTTP incorporated into DNA + inhibits thymidylate synthetase to deplete dTMP

Question 10

Vinblastine

Answer 10

solid tumor version of vincristine

Question 11

Tamoxifen

Answer 11

hormonal- estrogen antagonist, breast cancer, hot flashes + vasodilation + edema + nausea

Question 12

Daunorubicin

Answer 12

Doxorubicin analog for AML, classic + alopecia + cardiac toxicity

Question 13

Anastrozole

Answer 13

hormonal- aromatase inhibitor block extra-adrenal synthesis of estradiol, breast cancer, hot flashes

Question 14

Aprepitant

Answer 14

antiemetic- targets NK1 receptor and blocks substance P activity @ chemoreceptor trigger zone

Question 15

Bevacizumab

Answer 15

monoclonal Ab against VEGF- blocks angiogenesis, hypertension + proteinuria + poor wound healing

Question 16

Rituximab

Answer 16

monoclonal Ab against CD20 on B cells, B cell leukemia + lymphomas, infusion rxns (cytokine storm) + tumor lysis syndrome

Question 17

Irinotecan

Answer 17

topoisomerase 1 inhibitor + promotes strand breaks, colon cancer, classical

Question 18

Cisplatin

Answer 18

alkylating agent, 1st gen via platinum electrode, nephrotoxicity, peripheral neuropathies, mucositis, diarrhea,

Question 19

Carboplatin

Answer 19

alkylating agent, 2nd gen, hematopoietic toxicity (primarily), mucositis, diarrhea

Question 20

Capecitabine

Answer 20

antimetabolite- 5-FU oral form, converted to 5-FU in the liver

Question 21

Lapatinib

Answer 21

EGFR + Her-2/neu inhibitor, Her-2 pos metastatic breast cancer, rash + diarrhea

Question 22

Leuprolide

Answer 22

hormonal- GnRH receptor agonist, prostate cancer, edema + nausea + vomiting + gynaecomastia

Question 23

Letrozole

Answer 23

hormonal- aromatase inhibitor block extra-adrenal synthesis of estradiol, breast cancer, hot flashes

Question 24

Paclitaxel

Answer 24

microtubule inhibitor from pacific yew tree, ovarian/breast cancer, BM + peripheral neuropathy + skin eruptions + bronchospasms

Question 25

Ondansetron

Answer 25

antiemetic- blocks 5-HT-evoked firing on GI tract vagla endings and chemoreceptor trigger zone

Question 26

Topotecan

Answer 26

topoisomerase 1 inhibitor + promotes strand breaks, lung/ovarian cancer, classical

Question 27

Flutamide

Answer 27

hormonal- androgen receptor antagonist, prostate cancer, hot flashes + galactorrhea + impotence + vomiting + diarrhea

Question 28

Vincristine

Answer 28

microtubule inhibitor in M phase, leukemia + lymphoma + breast cancer, footdrop and constipation

Question 29

Doxorubicin

Answer 29

antibiotic, DNA intercalators- intercalate + free radicals + inhibit topoisomerase 2, breast cancer + lymphomas + sarcomas, classic + alopecia + cardiac toxicity

Question 30

Methotraxate

Answer 30

antimetabolite- depletion of folate and stops purine/thymidylate synthesis, childhood leukemia/lymphomas, breast cancer, BM, hepatic, renal impairment mucositis, diarrhea

Question 31

Oxaliplatin

Answer 31

alkylating agent, neurological toxicity, mucositis, diarrhea

Question 32

5-FU

Answer 32

antimetabolite- 5-FU incorporated into RNA + 5-FdUMP inhibits thymidylate synthase, colon/breast cancer, classic toxicities + hand-foot syndrome

Question 33

Gemcitabine

Answer 33

antimetabolite- DNA chain terminator via cytidine replacement + inhibits ribonucleotide reductase (can't make dNTP), pancreatic cancer + NSCLC, flu-like syndrome

Question 34

Erlotinib/Gefitinib

Answer 34

EGFR inhibitor + especially if it has activating EGFR mutation, NSCLC + pancreatic cancer, rash + diarrhea + fatigue + interstitial lung disease