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Pharmacology > RAT19 > Flashcards

RAT19 Flashcards

1
Q

Trazodone

A

atypical antidepressant, weak 5-HT transport inhibition, initiate neuroplasticity; depression + insomnia; SE: sedating

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2
Q

Disulfiram

A

Aldehyde dehydrogenase inhibitor, buildup of acetaldehyde causes hangover symptoms; alcohol addiction treatment

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3
Q

Suvorexant

A

Orexin receptor antagonist, block arousal signal from hypothalamus; insomnia

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4
Q

LSD, Mescaline, N,N-Dimethyltryptamine, Psilocin, Psilocybin

A

5-HT2 receptor agonists; hallucinogens

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5
Q

Phenelzine

A

MAO-A/B inhibitor, increase monoamines in CNS; depression, SE: tyramine toxicity

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6
Q

Methylphenidate

A

Transport inhibitor DA, NE, less of 5-HT; ADHD SE: CVS overactivation

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7
Q

Mirtazapine

A

atypical antidepressant, a2, 5-HT2,3 antagonist; depression; SE: sedation, overeating

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8
Q

Lithium Carbonate

A

inhibits inositol-1-phosphate hydrolysis; bipolar

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9
Q

Cocaine

A

Transport inhibitor DA, NE, 5-HT; local anesthetic, SE: CVS over-activation

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10
Q

Acamprosate

A

Restores balance btwn GABA and glutamate; alcohol addiction treatment

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11
Q

Amitriptyline, Desipramine, Imipramine, Nortriptyline

A

tricyclic antidepressant, NE, (less of 5-HT) transport inhibtion; depression SE: CVS over-activation, orthostatic hypotension due to a1-adrenergic blockade

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12
Q

Alcohol

A

Allosteric potentiation of GABAa receptors

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13
Q

Ramelteon

A

Melatonin receptor agnoist; insomnia (non-addicting)

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14
Q

Naltrexone

A

long acting opioid receptor antagonist, blocks euphoria of alcohol; alcohol addiction treatment

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15
Q

Varenicline

A

a4b2 nicotinic receptor partial agonist, also binds to 5-HT3 receptor; nicotine addiction management

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16
Q

Venlafaxine, Duloxetine

A

SSRI/SNRI; depression, generalized anxiety disorder, social phobia, SE: sexual dysfunction

17
Q

Amphetamine

A

Transport inhibitor DA, NE, less of 5-HT; ADHD, SE: CVS over-activation

18
Q

Zolpidem, Zaleplon, Eszopiclone

A

benzo agonists (not truly benzo), receptors that include 1a subunit; insomnia

19
Q

Buspirone

A

5-HT1A receptor partial agonist, reduces firing and release of certain 5-HT neurons in CNS; Generalize anxiety disorder + depression

20
Q

Guanfacine

A

a2 receptor agonist; depress brainstem neurons that control SNS; ADHD

21
Q

Alprazolam, Diazepam

A

benzo agonist on GABA receptor; acute anxiety with insomnia

22
Q

Fluoxetine, Setraline, Paroxetine, Citalopram, Escitalopram, Fluvoxamine

A

SSRI; all psychiatric; SE: sexual dysfunction

23
Q

MDMA

A

ecstasy, heteroexchange with monoamines predominantly 5-HT, increases 5-HT in CNS; empathy, SE: hyperthermia, hyponatremia, edema, unconciousness

24
Q

Cabamazepine, Valproate, Lamotrigine

A

stabilizes inactivated state of sodium channel, inhibits GABA metabolism; bipolar

25
Q

Triazolam, Temazepam, Diazepam

A

benzo agonist on GABA receptor; insomnia (short, medium, long acting, respectively)

26
Q

Chlordiazepoxide, oxazepam, lorazepam

A

benzo agonist on GABA receptor; used for alcohol withdrawal, oxazepam and lorazepam only undergo phase 2 rxn and preferred for liver damage

27
Q

THC, Dronabinol

A

CB1 receptor agonists, inhibit release of NT by feedback inhibition; nausea for cancer chemotherapy, AIDS-related wasting

28
Q

Fluoxetine + Olanzepine

A

SSRI + D2-like receptor, 5-HT2 receptor antagonist; bipolar

29
Q

Nicotine

A

Nicotinic receptor agonist, activates autonomic ganglion cells and chemoreceptor reflex, releases DA in reward pathway

30
Q

Bupropion

A

DA transport inhibitor, weak nicotinic receptor antagonist; nicotine addiction management + depression with overeating and oversleeping; SE: insomnia, anorexia

31
Q

Caffeine

A

Adenosine receptor antagonists (A1 and A2); stimulant

32
Q

Cariprazine

A

Partial D2/D3 receptor agonist; bipolar

33
Q

Atomoxetine

A

NE transport inhibitor; ADHD (non-addictive)

Pharmacology (20 decks)

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