Hormonal Therapies Flashcards
Mifepristone
PR antagonist, prevent maintenance of placenta; abortion
Raloxifene, bazedoxifene
SERM, ER agonist in bone, antagonist in brain breast uterus; ER+ breast cancer and osteoporosis, SE: hot flashes, thromboembolic disease
Ethinyl estradiol, Mestranol, combined with progestin
ER agonist intended to suppress GnRH, LH, FSH; oral contraception, SE: thromboembolic disease, hyperaldosterone
Ulipristal
PR modulator, suppress ovulation; emergency contraception
Degralix (Firmagon)
GnRH receptor antagonist, stops T secretion; advanced/metastatic prostate cancer
Urofolitropins
natural or recombinant FSH intended to stimulate oocyte development; assisted fertility
Levonorgestrel, 3-keto-desogestrel, medroxyprogesterone (progestins)
PR agonist; IUD, implantation, depot injection
Bicalutamide, Enzalutamide
Androgen receptor antagonist; advanced/metastatic prostate cancer
hCG
natural or recombinant hCG intended to stimulate ovulation; assisted fertility
Anastrozole, Letrozole
Aromatase inhibitors that prevent conversion of androgen to estrogen; ER+ breast cancer, SE: hot flashes, bone loss, joint pain, vaginal dryness
Medroxyprogesterone, norgestimate, norethindrone (progestins)
PR agonist, prevent estrogen action in uterus; HRT in women with intact uterus
Finasteride, Dutasteride
5-a-reductase inhibitors, inhibit DHT production; BPH, male pattern baldness
Abiraterone
CYP17,20 lyase inhibitor, inhibits production of testosterone; advanced/metastatic prostate cancer
Leuprolide, gosarelin
Long acting GnRH receptor agonists to prevent ovulation thru receptor downregulation; prevent premature ovulation in IVF, SE: bone loss
Leuprolide (Lupron)
GnRH receptor agonist, downregulates receptors; advanced/metastatic prostate cancer
Clomiphene
ER partial agonist in brain block estrogen feedback of GnRH secretion; infertility
Leuprolide, Gosarelin (in breast cancer)
Long acting GnRH analogs to prevent estrogen; preserve oocytes during chemo in premenopausal women with ER+ breast cancer, SE: bone loss
Ganirelix, cetrorelix
GnRH receptor antagonist to prevent ovulation thru receptor downregulation; prevent release of immature follicles and improve IVF
Oxandrolone, Oxymetholone
Androgen receptor agonists; HRT, endometriosis SE: testicular atrophy, infertility, prostate enlargement, dyslipidemia, liver disorders
CEE, estradiol
ER agonist; prevent post-menopausal symptoms, reduce osteoporosis, decrease CVD; HRT, SE: thromboembolic disease, increased breast/endometrial cancer if used without PR
GnRH (gonadorelin)
Stimulate LH release, and induce ovulation; Infertility
Tamoxifen
SERM, ER agonist in bone and uterus, antagonist in brain and breast; ER+ breast cancer, SE: hot flashes, thromboembolic disease, uterine cancer
Norethindrone, norgestrel, levonorgestrel, norgestimate (progestins)
PR agonist intended to suppress GnRH, LH, FSH, prevent dysfunctional uterine bleeding; oral contraception, SE: weak androgenic activity
Levonorgestrel
PR agonist, prevents ovulation; emergency contraception
