Catecholamine

Question 1

Phenylephrine

Answer 1

a1 receptor agonist, vasoconstriction

Question 2

Prazosin, Tamsulosin, Silodosin

Answer 2

a1 receptor antagonist (non-selective, 1a+1d, 1a) BPH

Question 3

Albuterol

Answer 3

short-acting B2 receptor agonist, relax sm. muscle; bronchospasm

Question 4

Epinephrine

Answer 4

non-selective B1 and B2 agonist; anaphylatic and cardiogenic shock, heart failure

Question 5

Dopamine

Answer 5

D1-like receptor agonist (dilates renal arteries), B receptor agonist at high dose, A receptor agonist at higher dose; cardiogenic shock with decreased urine output

Question 6

Timolol

Answer 6

non-selective B antagonist, reduces aqueous humor production at ciliary body; glaucoma

Question 7

Entacapone

Answer 7

peripheral COMT inhibitor; PD

Question 8

Dexmedetomidine

Answer 8

a2 receptor agonist; sedation and analgesia

Question 9

Brimonidine

Answer 9

a2 receptor agonist at ciliary body, reduces aqueous humor production; open-angle glaucoma

Question 10

Metoprolol, atenolol

Answer 10

b1 receptor antagonists, slow HR, and decrease CO via AV node; hypertension

Question 11

Carbidopa

Answer 11

peripheral decarboxylase inhibitor; PD

Question 12

Cocaine

Answer 12

blocks reuptake of NE, DA, 5-HT

Question 13

NE

Answer 13

a1 and b1 receptor agonist; hypotension due to vasodilation and low contractility

Question 14

Carvedilol

Answer 14

a1/b1/b2 receptor antagonist, slow HR via AV node; hypertension

Question 15

Pseudoephedrine

Answer 15

a1 receptor agonist, vasoconstriction

Question 16

Guanfacine

Answer 16

a2 receptor agonist at frontal lobe; ADHD

Question 17

Reserpine

Answer 17

block transport of NE, DA, 5-HT into synaptic vesicles; Hypertension

Question 18

Fenoldopam

Answer 18

Selective D1a receptor agonist; hypertension, heart failure

Question 19

Clonidine

Answer 19

a2 receptor agonist, depress brainstem neuron activity that control SNS; chronic pain conditions/spasticity

Question 20

Imipramine/Desipramine

Answer 20

blocks reuptake of NE > 5-HT; depression

Question 21

Amphetamine

Answer 21

blocks reuptake of NE, DA, less of 5-HT

Question 22

Phenelzine

Answer 22

non-selective MAO-B inhibitor; depression

Question 23

Oxymetazoline

Answer 23

a1 receptor agonist, vasoconstriction

Question 24

Methylphenidate

Answer 24

blocks reuptake of NE, DA, little of 5-HT; ADHD

Question 25

Nebivolol

Answer 25

selective B1 antagonist that also causes vasodilation via increased production of NO in vascular endothelial cells; hypertension

Question 26

Selegiline, Rasagiline

Answer 26

selective MAO-B inhibitor; PD

Question 27

Isoprenaline (isoproterenol)

Answer 27

non-selective B1 and B2 agonist; heart block

Question 28

Salmeterol, Formoterol

Answer 28

long-acting B2 receptor agonist, relax sm. muscle, inhibit mast cell degranulation; bronchospasm