Random Qs Rx Flashcards
Filgrastim - what is it?
G-CSF
Dexrazoxane - what is it?
Fe chelator, (-) Anthracycline (Doxorubicin) cardio tox (dilated cardiomyopathy)
Amifostine - used when?
Given with Cisplantin to dec nephrotox
Finasteride, Dutasteride - MOA, used for?
5 alpha reductase inhibitor, used in BPH
Tamsulosin, Silodosin - MOA
Alpha 1 - R (-)’r, used in BPH, urinary specific
Aldesleukin - what is it, used for?
IL-2, Melanoma & RCC
Alemtuzumab - MOA, which disease
Mab vs CD52, used in CLL;MS
Bevacizumab - MOA, which disease, SE?
(-) VEGF, Colorectal cancer, renal cell carcinoma, non-small cell lung cancer
SE// dec wound healing
Which Rx cause granulocytosis
Clozapine, Carbamazepine, Propylthiouracil, Methimazole, Colchicine, Ganciclovir
Rx that cause inc in LFTs
Statins, Ezetimibe, Amiodarone, Thyroid storm Cetuximab, Valproic acid, Bosentan
Rx that cause Hypothyroidism
Lithium, amiodarone, sulfonamides
Rx that cause hyperuricemia (Gout)
Pyrazinamide, Thiazides, Furosemide, Niacin, Cyclosporine
Antivirals - What are -Avirs, -Ivirs, -Ovirs used for?
-Avirs = AIDS, -Ivirs = Influenza, -Ovirs = Herpes
Detemir, Glargine are?
long acting insulin
Sulfonyureas - list them, MOA?
-Ides
1st gen: Chlorpropamide, Tolbutamide
2nd gen: Glimepiride, Glipizide, Glyburide
Close K+ channel in Beta cell membrane –> cell depolarizes –> insulin release via Inc Ca2+ influx
“Ides of March” - Ceaser Killed the K+ channel
SGLT2 (-)’rs - List and MOA?
Canaglifozin, Dapagliflozin, Empagliflozin - block reabsorption of glucose of PCT.
Stops the Glucose Flow In - Gli-flo-zin
Which Antibiotics are lipid soluble so therefore not eliminated by the kidney?
Doxycyclin, Ceftriaxone, Cefperazone, Naficillin, Oxacillin
IFN alpha used for?
Hep B& C, CML, Hairy B cell leukemia, Kaposi sarcoma
IFN Beta used for?
Inc length of remission in MS
IFN gamma used for?
Chronic granulomatous disease
Repaglinide - MOA?
Used in T2DB, stimulates postprandial insulin release by binding to K+ channels on B cell membranes (diff site from sulfonylureas)
Rx used in Hodgkin’s
A - Adriamycin
B - Bleomycin
V - Vincristine
D - Dacarbazine, Doxorubicin
Peracetam - MOA?
-racetams (like Levetiracetam) - may modulate GABA and glutamate release, used for clonus
SE// Fatigue, drowsiness, headache, neuropsychiatric
Rasburicase - MOA? Use?
Recombinant uricase that catalyzes metabolism of uric acid to allantoin (which is 5-10x more soluble). Prevention and treatment of tumor lysis syndrome.
Denosumab
(-) osteoclasts maturation, Ab vs RANK-L ; Osteoporosis
Leukovorin
used for Methrotrexate toxicity (save from myelosuppression)
N-Acetyl-Cysteine
vs Acetominophen Toxicity, Inc glutathione
Filgrastim
G-CSF
Sargagrastim
GM-CSF (stimulate granulocytes and monocytes)
MESNA
for hemorrhagic cystitis due to cyclophosphamide
List 5 SSRIs - SE// and Tox?
Sertraline, Fluoxetine, Paroxetine, Citalopram, Fluvoxamine
SE//Bruxism, dec libido, weight LOSS, anxiety
TOX// Serotonin syndrome
SSRIs are contraindicated with ?
MAOIs, Meperidine, TCAs
Rx that cause Pancreatitis?
Valproic acid, Didanosine & Stavudine (HIV rx), L-Asparaginase
Rx that cause Sulfa allergy
Carbonic anhydrase (-)’rs, Loops, Thiazides, Sulfonamides, Sulfonylureas, Celecoxib, Sumatriptan
Rx that can cause DB inspidus
Democlocycline , Li
Rx that cause Ototox/Nephrotox
Aminoglycosides, vancomycin, loop diuretics, cisplatin, amphotericin B
Disulfiram like reactions
1st-generation Sulfonylureas, Procarbazine,
certain Cephalosporins, Griseofulvin, Metronidazole
Rx that cause photosensitivty
Sulfonamides, Simepravir (HIV protease (-)'r ), Amiodarone, Tetracyclines, 5-FU,
Rx that act on Microtubules
Mebendazole (anti-helminthic) Griseofulvin (anti-fungal) Colchicine (anti-gout) Vincristine/Vinblastine Paclitaxel (used in breast/ovarian cancer)
SLE like reaction
Sulfa drugs, Hydralazine, Isoniazid,
Procainamide, Phenytoin, Etanercept, alpha methyldopa
Methotrexate - MOA? SE?
folic acid analog, (-) DHF reductase, will dec nucleotide precursors and WBC proliferation
SE// myelosuppression, hepato Tox, interstitial lung disease
Busulfan - MOA? SE?
DNA cross linking protein - will be cytotoxic to myeloid (low dose) and WBC (high dose).
Use for CML and w. cyclophosamide to prep for bone marrow transplant
SE//GI issues, pancytopenia, hyperpigmentation
Rx that lead to SIADH
Carbamazepine, Cyclophosphamide, SSRIs
Fomepizole
(-) alcohol DH, antidote for methanol ethylene gycol
Hydroxyurea
(-)ribonucleotide reductase
Rifampin
(-) RNA polymerase
Actinomycin D
inhibits RNA polymerase in both prokaryotes and eukaryotes.
TNF alpha assoc Rx
Adalimumab, certolizumab, golimumab, infliximab are all soluble TNF alpha.
Etanercept is a decoy TNF-α receptor and not a monoclonal antibody
Natalizumab - what is it, what diseases
α4-integrin, used in Crohn’s MS
Chloramphenicol
50S inhibitors, used Rickettsia if doxycyclin not avail
*(-) peptidyl transferase
(-) elongation at A–> P
Tetracyclin
works at A site, 30S inhibitor, bacteriostatic
Rx that causes Restless Leg syndrome
Pramipexole
Rx used in Paroxysmal Nocturnal Hematuria
Eculizumab
Paclitaxel is? used in?
Breast, ovarian cancer. - will Hyperstabilize polymerized microtubules in M phase so that mitotic spindle cannot break down (anaphase cannot occur).
Alemtuzumab
vs CD52 - used in CLL
Riluzole - for?
ALS
Rx for Essential Tremor
Non sel BB, Primidone
Mycophenolate
inhibit inosine
monophosphate dehydrogenase - inhibit purine synthesis
Rx that (-) de novo purine synthesis
6- Mercaptopurine, Azt
(-) dihydro folate reductase
MTX, TMP, Pyramethamine
(-) viral entry into cells
Enfuvirtide
Sibutramine
appetite suppressant no longer used
Flutamide
competitive antagonist at the androgen receptor, a nuclear receptor that affects transcription
Fibrates
(+) PPAR alpha to induce HDL synthesis, Inc LPL (Inc TAG clearence)
Triamterene
(-) Na channels @ collecting tubule; K sparing diuretic
