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Step 1 2019 First Aid Flashcards > Random Qs Rx > Flashcards

Random Qs Rx Flashcards

1
Q

Filgrastim - what is it?

A

G-CSF

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2
Q

Dexrazoxane - what is it?

A

Fe chelator, (-) Anthracycline (Doxorubicin) cardio tox (dilated cardiomyopathy)

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3
Q

Amifostine - used when?

A

Given with Cisplantin to dec nephrotox

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4
Q

Finasteride, Dutasteride - MOA, used for?

A

5 alpha reductase inhibitor, used in BPH

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5
Q

Tamsulosin, Silodosin - MOA

A

Alpha 1 - R (-)’r, used in BPH, urinary specific

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6
Q

Aldesleukin - what is it, used for?

A

IL-2, Melanoma & RCC

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7
Q

Alemtuzumab - MOA, which disease

A

Mab vs CD52, used in CLL;MS

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8
Q

Bevacizumab - MOA, which disease, SE?

A

(-) VEGF, Colorectal cancer, renal cell carcinoma, non-small cell lung cancer

SE// dec wound healing

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9
Q

Which Rx cause granulocytosis

A

Clozapine, Carbamazepine, Propylthiouracil, Methimazole, Colchicine, Ganciclovir

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10
Q

Rx that cause inc in LFTs

A

Statins, Ezetimibe, Amiodarone, Thyroid storm Cetuximab, Valproic acid, Bosentan

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11
Q

Rx that cause Hypothyroidism

A

Lithium, amiodarone, sulfonamides

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12
Q

Rx that cause hyperuricemia (Gout)

A

Pyrazinamide, Thiazides, Furosemide, Niacin, Cyclosporine

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13
Q

Antivirals - What are -Avirs, -Ivirs, -Ovirs used for?

A

-Avirs = AIDS, -Ivirs = Influenza, -Ovirs = Herpes

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14
Q

Detemir, Glargine are?

A

long acting insulin

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15
Q

Sulfonyureas - list them, MOA?

A

-Ides
1st gen: Chlorpropamide, Tolbutamide
2nd gen: Glimepiride, Glipizide, Glyburide
Close K+ channel in Beta cell membrane –> cell depolarizes –> insulin release via Inc Ca2+ influx

“Ides of March” - Ceaser Killed the K+ channel

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16
Q

SGLT2 (-)’rs - List and MOA?

A

Canaglifozin, Dapagliflozin, Empagliflozin - block reabsorption of glucose of PCT.

Stops the Glucose Flow In - Gli-flo-zin

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17
Q

Which Antibiotics are lipid soluble so therefore not eliminated by the kidney?

A

Doxycyclin, Ceftriaxone, Cefperazone, Naficillin, Oxacillin

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18
Q

IFN alpha used for?

A

Hep B& C, CML, Hairy B cell leukemia, Kaposi sarcoma

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19
Q

IFN Beta used for?

A

Inc length of remission in MS

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20
Q

IFN gamma used for?

A

Chronic granulomatous disease

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21
Q

Repaglinide - MOA?

A

Used in T2DB, stimulates postprandial insulin release by binding to K+ channels on B cell membranes (diff site from sulfonylureas)

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22
Q

Rx used in Hodgkin’s

A

A - Adriamycin
B - Bleomycin
V - Vincristine
D - Dacarbazine, Doxorubicin

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23
Q

Peracetam - MOA?

A

-racetams (like Levetiracetam) - may modulate GABA and glutamate release, used for clonus
SE// Fatigue, drowsiness, headache, neuropsychiatric

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24
Q

Rasburicase - MOA? Use?

A

Recombinant uricase that catalyzes metabolism of uric acid to allantoin (which is 5-10x more soluble). Prevention and treatment of tumor lysis syndrome.

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25
Q

Denosumab

A

(-) osteoclasts maturation, Ab vs RANK-L ; Osteoporosis

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26
Q

Leukovorin

A

used for Methrotrexate toxicity (save from myelosuppression)

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27
Q

N-Acetyl-Cysteine

A

vs Acetominophen Toxicity, Inc glutathione

28
Q

Filgrastim

A

G-CSF

29
Q

Sargagrastim

A

GM-CSF (stimulate granulocytes and monocytes)

30
Q

MESNA

A

for hemorrhagic cystitis due to cyclophosphamide

31
Q

List 5 SSRIs - SE// and Tox?

A

Sertraline, Fluoxetine, Paroxetine, Citalopram, Fluvoxamine

SE//Bruxism, dec libido, weight LOSS, anxiety
TOX// Serotonin syndrome

32
Q

SSRIs are contraindicated with ?

A

MAOIs, Meperidine, TCAs

33
Q

Rx that cause Pancreatitis?

A

Valproic acid, Didanosine & Stavudine (HIV rx), L-Asparaginase

34
Q

Rx that cause Sulfa allergy

A

Carbonic anhydrase (-)’rs, Loops, Thiazides, Sulfonamides, Sulfonylureas, Celecoxib, Sumatriptan

35
Q

Rx that can cause DB inspidus

A

Democlocycline , Li

36
Q

Rx that cause Ototox/Nephrotox

A

Aminoglycosides, vancomycin, loop diuretics, cisplatin, amphotericin B

37
Q

Disulfiram like reactions

A

1st-generation Sulfonylureas, Procarbazine,

certain Cephalosporins, Griseofulvin, Metronidazole

38
Q

Rx that cause photosensitivty

A 
Sulfonamides, 
Simepravir (HIV protease (-)'r ), 
Amiodarone, 
Tetracyclines, 
5-FU,
39
Q

Rx that act on Microtubules

A 
Mebendazole (anti-helminthic)
Griseofulvin (anti-fungal)
Colchicine (anti-gout)
Vincristine/Vinblastine
Paclitaxel (used in breast/ovarian cancer)
40
Q

SLE like reaction

A

Sulfa drugs, Hydralazine, Isoniazid,

Procainamide, Phenytoin, Etanercept, alpha methyldopa

41
Q

Methotrexate - MOA? SE?

A

folic acid analog, (-) DHF reductase, will dec nucleotide precursors and WBC proliferation

SE// myelosuppression, hepato Tox, interstitial lung disease

42
Q

Busulfan - MOA? SE?

A

DNA cross linking protein - will be cytotoxic to myeloid (low dose) and WBC (high dose).

Use for CML and w. cyclophosamide to prep for bone marrow transplant

SE//GI issues, pancytopenia, hyperpigmentation

43
Q

Rx that lead to SIADH

A

Carbamazepine, Cyclophosphamide, SSRIs

44
Q

Fomepizole

A

(-) alcohol DH, antidote for methanol ethylene gycol

45
Q

Hydroxyurea

A

(-)ribonucleotide reductase

46
Q

Rifampin

A

(-) RNA polymerase

47
Q

Actinomycin D

A

inhibits RNA polymerase in both prokaryotes and eukaryotes.

48
Q

TNF alpha assoc Rx

A

Adalimumab, certolizumab, golimumab, infliximab are all soluble TNF alpha.

Etanercept is a decoy TNF-α receptor and not a monoclonal antibody

49
Q

Natalizumab - what is it, what diseases

A

α4-integrin, used in Crohn’s MS

50
Q

Chloramphenicol

A

50S inhibitors, used Rickettsia if doxycyclin not avail
*(-) peptidyl transferase
(-) elongation at A–> P

51
Q

Tetracyclin

A

works at A site, 30S inhibitor, bacteriostatic

52
Q

Rx that causes Restless Leg syndrome

A

Pramipexole

53
Q

Rx used in Paroxysmal Nocturnal Hematuria

A

Eculizumab

54
Q

Paclitaxel is? used in?

A

Breast, ovarian cancer. - will Hyperstabilize polymerized microtubules in M phase so that mitotic spindle cannot break down (anaphase cannot occur).

55
Q

Alemtuzumab

A

vs CD52 - used in CLL

56
Q

Riluzole - for?

A

ALS

57
Q

Rx for Essential Tremor

A

Non sel BB, Primidone

58
Q

Mycophenolate

A

inhibit inosine

monophosphate dehydrogenase - inhibit purine synthesis

59
Q

Rx that (-) de novo purine synthesis

A

6- Mercaptopurine, Azt

60
Q

(-) dihydro folate reductase

A

MTX, TMP, Pyramethamine

61
Q

(-) viral entry into cells

A

Enfuvirtide

62
Q

Sibutramine

A

appetite suppressant no longer used

63
Q

Flutamide

A

competitive antagonist at the androgen receptor, a nuclear receptor that affects transcription

64
Q

Fibrates

A

(+) PPAR alpha to induce HDL synthesis, Inc LPL (Inc TAG clearence)

65
Q

Triamterene

A

(-) Na channels @ collecting tubule; K sparing diuretic

Step 1 2019 First Aid Flashcards (63 decks)

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