MuscSkCT - FA Patho Derm p465 - 473 Flashcards
Name the pathology associated with this dermal morphology: honey crusts
Impetigo caused by GAS
Name the pathology associated with this dermal morphology: transient smooth plaque/papule known as wheal
Urticaria
Name the pathology associated with this dermal morphology: bulla
Bullous pemphigoid,
Name the pathology associated with this dermal morphology: flaking off skin, scales
Psoriasis Eczema
Hemidesmosomes connect ————— to ————? Which pathology is associated with it?
keratin in basal cells ; basement membrane. Bullous pemphigoid
Which layer of the epidermis produces progenitor cells
Stratum Basale
Which layer of the epidermis has diffuse layers of keratin?
Stratum Corneum
Which layer of the epidermis has desmosomes? Which pathology is associated with them
Stratum spinosum. Auto immune destruction of desmosomes is observed in pemphigous vulgaris
Which structure allows for communication in gaps junctions?
Connexons (channel proteins)
Loss of these filaments with these abnormal proteins in this junction leads to metastasis?
Mutated E-cadherins without actin filaments in Zonula adherens (Adherens JXN)
Which tumors is MG associated with
Thymoma
Which type of hypersensitivity is Vitiligo associated with
Type IV
Failure of NC to migrate to the skin and decreased number of melanocytes
Piebaldism
normal migration of NC cells with decreased melanin granules
Albinism
What two conditions can lead to acquired hyperpigmentation of the face in females?
1) Pregnancy 2) OCP usage
Differentiate b/w Acantholysis and Acanthosis (pathologies associated with it)
Acanthosis- epidermal hyperplasia (nigricans in metabolic syndrome) Acantholyis- separation of epidermal cells (pemphigus vulgaris
staphylococcal Exotoxin destroys keratinocyte attachments in — only vs. toxic epidermal necrolysis, which destroys —.
stratum granulosum epidermal-dermal junction
T or F? HSV1 and HSV2 can cause herpetic whitlow?
T (finger) (dentist and wrestlers)
Which infection involving upper dermis and superficial lymphatics, usually from S. pyogenes?
Erysipelas
Which infection causes multiple crops of lesions in various stages from vesicles to crusts?
Varicella zoster virus
Erythema multiforme is associated with which infections, paths and drugs?
Infection: Mycoplasma pneumoniae, HSV
drugs: sulfa drugs, β-lactams, phenytoin cancers autoimmune disease
A small, rough, erythematous or brownish papules or plaques that inc the risk of squamous cell carcinoma is called what?
Actinic keratosis
Hairy leukoplakia occurs in what kind of pt? What virus mediates it?
Occurs in HIV-positive patients, organ transplant recipients. EBV mediated
What is a more severe form of Stevens-Johnson syndrome with > 30% of the body surface area involved ?
toxic epidermal necrolysis
Obese Pt with gastric adenocarcinoma may present with what type of kind disorder?
Acanthosis nigricans (hyperplasia of spinosum)
Wickham striae seen in Lichen Planus refers to what?
Mucosal involvement manifestations, (reticular white lines)
Lichen Planus is associated with what virus?
Associated with hepatitis C, HHV-8
Erythema nodosum is associated with what 7 conditions?
sarcoidosis, coccidioidomycosis, histoplasmosis, TB, streptococcal infections, leprosy , Crohn disease
Which environmental derm issue can lead to impetigo?
Sunburn
Exotoxin destroys keratinocyte attachments in — only vs. toxic epidermal necrolysis, which destroys —.
stratum granulosum epidermal-dermal junction
— is dominant in tanning and photoaging, — in sunburn.
UVA UVB
“palisading” nuclei is see in: “pseudopalisading” nuclei is seen in:
Basal cell tumors,
Schwanomas Glioblastoma multiforme, Neuroblastoma
Ulcerative red lesions, associated with scaling describes what pathology?
Squamous cell carcinoma ( assoc with actinic ketatosis)
looks like squamous cell carcinoma that grows rapidly (4–6 weeks) and may regress spontaneously over months.
Kerato acanthoma
Paths that are S-100?
Langerhans cell histiocytosis Schwannoma Melanoma
keratin “pearls” seen in 2 paths?
Squamous cell carcinoma of lung Squamous cell carcinoma of skin
Pink, pearly nodules, commonly with —, rolled borders and central crusting or ulceration describes what path?
telangiectasias Basal cell carcinoma (pears on the base of ocean)
Which scaly plaque is precursor to squamous cell carcinoma?
Actinic keratosis
BRAF gene mutation is seen in what 4 paths?
- Serrated polyps
- non Hodgkins lymphoma
- hairy cell leukemia
- Papillary carcinoma of thyroid
- Melanoma
- Letterer-siwe ( type of Langerhans cell histiocytosis)
At what diameter can we call a lesion melanoma?
>6 mm
Metastatic or unresectable melanoma in patients with — mutation can be treated with vemurafenib.
BRAF V600E (valine to glutamate)
Name 4 types of melanoma?
superficial spreading
nodular - worst
lentigo maligna - older, multinucleated melanocytes
acral lentiginous - on feet or palmer surface
Deposits of IgA at tips of dermal papillae is seen in what blistering skin disorder? What type of HS?
Dermatitis herpetiformis HS type III
What blistering skin disorder shows immunofluorescence of antibodies around epidermal cells in a reticular (net-like) pattern?
Pemphigus vulgaris
Apoptosis of keratinocytes is seen in what skin disorder?
sunburn
Erythema nodosum is lesion of what?
painful inflammatory lesions of subcutaneous fat
