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Step 1 2019 First Aid Flashcards > MuscSkCT - FA Patho Derm p465 - 473 > Flashcards

MuscSkCT - FA Patho Derm p465 - 473 Flashcards

1
Q

Name the pathology associated with this dermal morphology: honey crusts

A

Impetigo caused by GAS

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2
Q

Name the pathology associated with this dermal morphology: transient smooth plaque/papule known as wheal

A

Urticaria

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3
Q

Name the pathology associated with this dermal morphology: bulla

A

Bullous pemphigoid,

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4
Q

Name the pathology associated with this dermal morphology: flaking off skin, scales

A

Psoriasis Eczema

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5
Q

Hemidesmosomes connect ————— to ————? Which pathology is associated with it?

A

keratin in basal cells ; basement membrane. Bullous pemphigoid

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6
Q

Which layer of the epidermis produces progenitor cells

A

Stratum Basale

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7
Q

Which layer of the epidermis has diffuse layers of keratin?

A

Stratum Corneum

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8
Q

Which layer of the epidermis has desmosomes? Which pathology is associated with them

A

Stratum spinosum. Auto immune destruction of desmosomes is observed in pemphigous vulgaris

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9
Q

Which structure allows for communication in gaps junctions?

A

Connexons (channel proteins)

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10
Q

Loss of these filaments with these abnormal proteins in this junction leads to metastasis?

A

Mutated E-cadherins without actin filaments in Zonula adherens (Adherens JXN)

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11
Q

Which tumors is MG associated with

A

Thymoma

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12
Q

Which type of hypersensitivity is Vitiligo associated with

A

Type IV

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13
Q

Failure of NC to migrate to the skin and decreased number of melanocytes

A

Piebaldism

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14
Q

normal migration of NC cells with decreased melanin granules

A

Albinism

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15
Q

What two conditions can lead to acquired hyperpigmentation of the face in females?

A

1) Pregnancy 2) OCP usage

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16
Q

Differentiate b/w Acantholysis and Acanthosis (pathologies associated with it)

A

Acanthosis- epidermal hyperplasia (nigricans in metabolic syndrome) Acantholyis- separation of epidermal cells (pemphigus vulgaris

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17
Q

staphylococcal Exotoxin destroys keratinocyte attachments in — only vs. toxic epidermal necrolysis, which destroys —.

A

stratum granulosum epidermal-dermal junction

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18
Q

T or F? HSV1 and HSV2 can cause herpetic whitlow?

A

T (finger) (dentist and wrestlers)

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19
Q

Which infection involving upper dermis and superficial lymphatics, usually from S. pyogenes?

A

Erysipelas

20
Q

Which infection causes multiple crops of lesions in various stages from vesicles to crusts?

A

Varicella zoster virus

21
Q

Erythema multiforme is associated with which infections, paths and drugs?

A

Infection: Mycoplasma pneumoniae, HSV

drugs: sulfa drugs, β-lactams, phenytoin cancers autoimmune disease

22
Q

A small, rough, erythematous or brownish papules or plaques that inc the risk of squamous cell carcinoma is called what?

A

Actinic keratosis

23
Q

Hairy leukoplakia occurs in what kind of pt? What virus mediates it?

A

Occurs in HIV-positive patients, organ transplant recipients. EBV mediated

24
Q

What is a more severe form of Stevens-Johnson syndrome with > 30% of the body surface area involved ?

A

toxic epidermal necrolysis

25
Q

Obese Pt with gastric adenocarcinoma may present with what type of kind disorder?

A

Acanthosis nigricans (hyperplasia of spinosum)

26
Q

Wickham striae seen in Lichen Planus refers to what?

A

Mucosal involvement manifestations, (reticular white lines)

27
Q

Lichen Planus is associated with what virus?

A

Associated with hepatitis C, HHV-8

28
Q

Erythema nodosum is associated with what 7 conditions?

A

sarcoidosis, coccidioidomycosis, histoplasmosis, TB, streptococcal infections, leprosy , Crohn disease

29
Q

Which environmental derm issue can lead to impetigo?

A

Sunburn

30
Q

Exotoxin destroys keratinocyte attachments in — only vs. toxic epidermal necrolysis, which destroys —.

A

stratum granulosum epidermal-dermal junction

31
Q

— is dominant in tanning and photoaging, — in sunburn.

A

UVA UVB

32
Q

“palisading” nuclei is see in: “pseudopalisading” nuclei is seen in:

A

Basal cell tumors,

Schwanomas Glioblastoma multiforme, Neuroblastoma

33
Q

Ulcerative red lesions, associated with scaling describes what pathology?

A

Squamous cell carcinoma ( assoc with actinic ketatosis)

34
Q

looks like squamous cell carcinoma that grows rapidly (4–6 weeks) and may regress spontaneously over months.

A

Kerato acanthoma

35
Q

Paths that are S-100?

A

Langerhans cell histiocytosis Schwannoma Melanoma

36
Q

keratin “pearls” seen in 2 paths?

A

Squamous cell carcinoma of lung Squamous cell carcinoma of skin

37
Q

Pink, pearly nodules, commonly with —, rolled borders and central crusting or ulceration describes what path?

A

telangiectasias Basal cell carcinoma (pears on the base of ocean)

38
Q

Which scaly plaque is precursor to squamous cell carcinoma?

A

Actinic keratosis

39
Q

BRAF gene mutation is seen in what 4 paths?

A
  • Serrated polyps
  • non Hodgkins lymphoma
  • hairy cell leukemia
  • Papillary carcinoma of thyroid
  • Melanoma
  • Letterer-siwe ( type of Langerhans cell histiocytosis)
40
Q

At what diameter can we call a lesion melanoma?

A

>6 mm

41
Q

Metastatic or unresectable melanoma in patients with — mutation can be treated with vemurafenib.

A

BRAF V600E (valine to glutamate)

42
Q

Name 4 types of melanoma?

A

superficial spreading

nodular - worst

lentigo maligna - older, multinucleated melanocytes

acral lentiginous - on feet or palmer surface

43
Q

Deposits of IgA at tips of dermal papillae is seen in what blistering skin disorder? What type of HS?

A

Dermatitis herpetiformis HS type III

44
Q

What blistering skin disorder shows immunofluorescence of antibodies around epidermal cells in a reticular (net-like) pattern?

A

Pemphigus vulgaris

45
Q

Apoptosis of keratinocytes is seen in what skin disorder?

A

sunburn

46
Q

Erythema nodosum is lesion of what?

A

painful inflammatory lesions of subcutaneous fat

Step 1 2019 First Aid Flashcards (63 decks)

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