Neuro - FA p478-498 Flashcards
what induces the overlying ectoderm to differentiate into neuroectoderm and neural plate
notochord
notochord becomes what in adults
nucleus pulposus
list the 3 major region that makes up the three primary vesicles of developing the brain
fore, mid and hind brain
what do the proescephalon form
telencephalon & diencephalon
what does the telencephalon form
cerebral hemisphere, basal ggl and lateral ventricle
what does the diencephalon form
thalamus, hypothalamus and 3rd ventricle
what does the mesencephalon form
midbrain and aqueduct
what does the rhombocephalon divide into
metencephalon and mylencephalon
metencephalon forms
pons, cerebellum and upper part of 4th ventricle
myelencephalon forms
medulla and lower part of 4th ventricle
where do the microglia cells originate from
mesoderm
failure of the bony spinal canal to close with the dura intact is associated with what pathology
spinal bifida occulta (tuft of hair)
spinal problem with normal AFP
spinal bifida occulta
diff btw meningocele and meningomylocele
meningocele: meninges herniate only thru spinal canal meninogemylocele: meninges and spinal card herniation
anencephaly is due to which embryo error?
Failure of rostral neuropore to close –> no forebrain, open calvarium.
failure of left and right hemisphere to separate; which gene and diseases is it associated with? What does MRI show?
holoprosencephaly, sonic hedgehog gene & patau syndrome/fetal alcohol syndrome
MRI - monoventricle and fusion of basal ggl
Cyclopia seen with?
most severe form of holoprosencephaly; trisomy 13, fetal alchohol syndrome
lack of cerebral vermis and an cystic enlarged 4th ventricle? list 2 associations
Dandy walker
associated with non commmunicating hydrocephalus & spinal bifida
what disease is associated with meningomylocele; how does it present?
Arnold Chiari type II - Sx/ paralysis / sensory loss at or below level of lesion
Bilateral loss of pain and temperature sensation in upper limb?
Sphingomyelia
Which part of the spinal cord affected in Sphingomyelia?
Most common at C8–>T1
Intention tremor plus loss of pain and temp sensation in UL?
Chiari I malfomation - cerebellar tonisillar ectopia >3-5mm
assoc w/ syringomyelia
Which fibers are destroyed in Syringomyelia?
crossed fibers in ant white commissure ( spinothalamic tract)
Which arches are responsible for the ant 2/3 tongue? Gen sens’n nerve? Nerve for taste?
1st and 2nd arch, Mandibular n (V3), Facial n (VII)
Which arches for the post 1/3 of tongue? N for gen sens’n and taste?
3rd and 4th arch, CN IX, root is CN X
Function of hyoglossus, genioglossus, and styloglossus?
Hyo - retracts and lower tongue Genio - protrudes tongue Stylo - pulls sides of tongue upwards
Which nerves innervates which muscles of tongue?
All muscles of tongue inn by CN XII, except palatoglossus, by CN X
Nissl staining stains what (what parts of neuron) and what molecular structure?
rER, so therefore only stains the body of neuron, not axon
What is Wallerian degeneration?
disintegration of the axon and myelin sheath distal to site of axonal injury with macrophages removing debris.
Where can axons regenerate?
Peripheral Nervous System
Which neuro cell type is a buffer for EC K+ and removes excess neurotransmitter?
Astrocytes
Marker of Astrocytes? embryo origin?
GFAP; from neuroectoderm
Embryo origin of microglial cells?
mesodermal origin, from monocytes in Bone marrow
In HIV, what neurological reaction occurs in the CNS and with which cell type?
fomation of multinucleated giant cells from microglia
Which cells produce the myelin sheath in CNS and PNS?
CNS - oligodendrocytes PNS - Schwann cells
What type of channels are seen at the nodes of Ranvier?
Na+ channels (where AP happens!)
Schwann cells are injured in which disease, causing ascending paralysis? Assoc with which microbe?
Guillan Barre syndrome, C. jejuni
Embryo origin of Schwann cells?
neural crest
What is the difference in myelination between Schwann cells and oligodendrocytes? (other than location)
A Schwann cell can only myelinate one single PNS axon An oligodendrocyte can myelinate several (about 30) CNS axons
What neuro cell have a fried egg appearance histo wise?
Oligodendroglia
What 3 diseases are associated with damage to oligodendroglia?
MS, PML (Progressive multifocal leukoencephalopathy), leukodystrophy
Difference between C and A delta fibers?
C - slow and unmyelinated (C student is slow) A - fast, myelinated)
Where are meissner corpuscles located? What do they sense?
hairless skin, fine touch and position sense
Where are pacinian corpuscles located? What do they sense?
Deep skin layers, ligaments, joints vibration, pressure
Where are Merkel discs located? What do they sense?
Finger tips, superficial skin Pressure, deep touch, position sense
Where are ruffini corpuscles? What do they sense?
finger tips, joints Pressure, slippage of objects along surface of skin, joint angle change
Location of synthesis of Ach? Inc /Dec in which disease?
Made at Basal nucleus - Inc in Parkinsons, Dec in Alzheimer, Huntingtons
Synthesis location of Dopamine
Ventral tegmentum, Substancia Nigra (pars compacta)
Inc/Dec Dopamine in which diseases?
Dec in depression, parkinson, Inc in Schizophrenia, Huntington Dopamine involved in initiation of movement, so dec in depression (dec will to do activity) and parkinson (issue starting movement)
GABA is made in
Nucleus Accumbens (GABANA)
GABA dec in
Huntingtons, Anxiety ( dec inhibition of movement)
Where is NE made?
Locus ceruleus
NE inc/Dec in?
Inc = anxiety, dec = depression
Serotonin is made where?
Raphe nucleus
Serotonin is inc/dec where?
Dec in Anxiety, Depression and Parkinson’s
Embryo origin of dura mater vs arachnoid/pia mater?
Dura - mesoderm Arachnoid/pia - neural crest
3 parts to the BBB?
Tight junctions between nonfenestrated capillary endothelial cells, BM, Astrocyte foot processes
What substances can penetrate the blood brain barrier?
Glucose and amino acids cross slowly by carriermediated transport mechanisms. Nonpolar/lipid-soluble substances cross rapidly via diffusion.
Where is there a break in BBB to allow for secretion?
At the Hypothalamus for the secretion of ADH, Oxytocin and releasing factors.
2 major inputs to HT not protected by BBB?
- OVLT (organum vasculosum of lamina terminalis, senses changes in Osmo 2. Area postrema
Which area of HT manages hunger? Stimulated/inhibited by?
Lateral area - Inc by Ghrelin, inhibited by leptin
A cranipharyngioma of this area of the HT leads to hyperphagia, stimulated by what hormone?
VM - can be stimulated by leptin
Which autonomic nervous system affects the cooling center?
PANS - bc when you’re resting and digesting, you want to be cool.
Which nucleus causing cooling?
Ant - for A/C
Which nucleus is responsible for heating?
Post - her butt is HOT
Which nucleus is responsible for circadian rhythm?
Suprachiasmatic nucleus - You need to see light to have a good circadian rhythm
Ipsilateral proprioceptive information from spinal cord travel to cerebellum through ____ ?
inferior cerebellar peduncle
Input from contralateral cortex to cerebellum through ____ ?
middle cerebellar peduncle
output: Cerebellum to contralat cortex through ____ ? from what cell type, and is it stimulatory or inhibitory
Superior Cerebellar peduncle; from purkinje cells, inhibitory
patient has damage to lateral lobes of cerebellum. what are the symptoms?
fall towards injured sides affects voluntary movement extremities
Patient with truncal ataxia. which part of cerebellum, which other symptoms?
Medial lesions (vermis, fastigial nuclei, or flocculonodular lobe) - truncal ataxia w/ nystagmus, head tilting, bilateral motor defecits
Liste the Deep nuclei in cerebellum
Don’t Eat Greasy Food Dentate, Emboliform, Globose, Fastigal
circardian rhythm which nucleus
suprachiasmatic nucleus
describe the pathway of melatonin release
SupraChiasmaticNucleus –> NE –> pineal gland –> Melatonin
Extraocular movements during REM sleep is due to activity of what?
PPRF paramedian pontine reticular formation/conjugate gaze center
List the causes that decrease REM/ delta wave sleep
alcohol, benzo, barbituates - dec both. NE - dec REM sleep
How does Depression affect REM sleep?
Depression increases total REM sleep but decreases REM latency, dec N3, repeated nighttime awakenings, early morning awakening (terminal insomnia).
when stage of sleep does bedwetting occur? and what other 2 patho occurs in that stage too?
Stage N3 (Delta) others: sleep walking, night terrors
what are the difference between nightmares and night terrors?
nightmares in REM sleep
night terrors in Stage N3
treatment of night terrors and sleepwalking
BDZ - they lower stage 3 and REM sleep.
treatment of sleep enuresis
oral desmopressin ADH analog (nasal form is banned) Imipramine, Amitriptyline Nortriptyline (TCAs) not preferred bc of Side effects (alpha (-)’r so postural HTN, and anti-muscarinic). Tx of choice - motivational therapy
Bruxism, which stage
“You grind your teeth like spindles and complexes in most amount of time” - Sleep spindles and K complexes. -which is stage N2 (45% = most amount of time)