Micro FA Systems p178 - 186 Flashcards
T or F Neonates delivered by C section have no bacterial flora
T - Neonates delivered by C-section have no flora but are rapidly colonized after birth

Which bact cause fast and furious food poisoning? (starts and ends quickly)
B. cereus
S. aureus



Pathogens causing bloody diarrhea
Campylobacter, E. histolytica, EHEC, EIEC, Salmonella, Shigella, Y. enterocolitica
bact causing watery diarrhea
C Diff, C perfringens, ETEC, V cholerae
Protozoa causing watery diarrhea
Giardia, Cryptosporidium
Viruses causing watery diarrhea
Rotavirus, norovirus, enteric adenovirus
Most common cause of pneumonia in neonates (<4wk)
Group B streptococci E coli
Most common cause of pneumonia in children?
Viruses (RSV)
- *M**ycoplasma
- *C** trachomatis (infants–3 yr)
- *C** pneumoniae (school-aged children)
- *S p**neumoniae
Runts May Cough Chunky Sputum
Most common cause of pneumonia in adults (18-40)
Mycoplasma C pneumoniae S pneumoniae Viruses (eg, influenza
Pneumonia in adults (40-65)
S pneumoniae H influenzae Anaerobes Viruses Mycoplasma
Causes on pneumonia in elderly
S pneumoniae Influenza virus Anaerobes H influenzae Gram ⊝ rods
Causes of pneumonia in Alcoholics
Klebsiella, anaerobes usually due to aspiration (eg, Peptostreptococcus, Fusobacterium, Prevotella, Bacteroides)
Pneumonia in IV drug users?
S pneumo
S aureus
Aspiration pneumonia cause
anaerobes
Causes of atypical pneumonia
Mycoplasma, Chlamydophila, Legionella, viruses (RSV, CMV, influenza, adenovirus)
Pneumonia in CF pts
Pseudomonas, S aureus, S pneumoniae, Burkholderia cepacia
Immunocompromised pts - causes of pneumonia
S aureus, enteric gram ⊝ rods, fungi, viruses, P jirovecii (with HIV)
Nosocomial pneumonia
S aureus
Pseudomonas
other G- enteric rods
Post viral pneumonia
S pneumo
S aureus
H influenzae
What do we give for meningitis? What do we add if Listeria is suspected?
Give ceftriaxone and vancomycin empirically (add ampicillin if Listeria is suspected).
Viral causes of meningitis?
- enteroviruses (Polio, Echo, Coxsackie virus),
- HSV-2 (HSV-1 = encephalitis), VZV.
- HIV,
- West Nile virus (also causes encephalitis),
Common causes of meningitis in newborns (0-6mo)
Group B streptococci
E coli
Listeria
Meningitis causes in children (6mo - 6yr)
S pneumoniae
N meningitidis
H influenzae type b
Enteroviruses
Meningitis causes in 6-60yrs
S pneumoniae
N meningitidis
Enteroviruses
HSV
Number 1 cause of meningitis in teens
Neisseria
Meningitis causes in elderly (60 +)
S pneumo
G- rods
Listeria
CSF findings in meningitis
Most common causes of brain abscess
viridans streptococci
S aureus
Where do temporal lobe & cerebellum / frontal lobe abscesses transfer from?
otitis media and mastoiditis –> temporal lobe and cerebellum; sinusitis or dental infection –> frontal lobe
Brain abscess in AIDS pt caused by?
Toxoplasma activation
Most common cause overall of osteomyelitis
S aureus
Osteomyelitis in sexual active person?
Neisseria gon (but rare)
Sickle cell osteomyelitis
Salmonella
S aureus
Prosthetic joint replacement osteomyelitis
S aureus and S epidermidis
Osteomyelitis in the vertebrae
S aureus
Pott disease (Myco Tb)
Osteomyelitis assoc w/ cat/dog bite
Pasteurella
Osteomyelitis assoc w/ IV drug use
S aureus
Pseudomonas
Candida
Testing for Osteomyelitis
- Lab values
- Imaging
Elevated ESR and CRP sensitive but not specific. Radiographs are insensitive early but can be useful in chronic osteomyelitis MRI is best for detecting acute infection and detailing anatomic involvement
Sx of UTI
Cystitis presents with dysuria, frequency, urgency, suprapubic pain, and WBCs (but not WBC casts) in urine
Presentation of pyelonephritis
. Ascension to kidney results in pyelonephritis, which presents with fever, chills, flank pain, costovertebral angle tenderness, hematuria, and WBC casts.
Risk factors for UTI`
obstruction (eg, kidney stones, enlarged prostate), kidney surgery, catheterization, congenital GU malformation (eg, vesicoureteral reflux), diabetes, pregnancy.
The leading cause of UTI? What growth medium is it grown on? What do the colonies look like?
Escherichia coli - Leading cause of UTI. Colonies show strong pink lactose-fermentation on MacConkey agar
⊕ Leukocyte esterase in UTI indicates what?
evidence of WBC activity
⊕ Nitrite test indicates what in UTI?
reduction of urinary nitrates by gram ⊝ bacterial species (eg, E coli).
Which UTI bugs produce urease
S saprophyticus, Proteus, Klebsiella
2nd/ 3rd leading cause of UTI ?
s. saprophyticus
K pneumoniae
2 nosocomial causes of UTI
Serratia marscescens
Enterococcus
Pseudomonas
Motility causes “swarming” on agar; associated with struvite stones.
Proteus
Blue-green pigment and fruity odor;
Pseudomonas
Thin white vaginal discharge with fishy odor and bubbles
Gardnerella vaginalis
What are clue cells?
vaginal epith cells covered with bacteria
Tx for Bact vaginosis
Metronidazole
Clindamycin
strawberry cervix, Frothy, yellow-green, foulsmelling discharge - Pathogen? shape of it?
Motile pear-shaped trichomonads (Trichomonas vaginalis)
tx for Trichomonas?
Metronidazole
strawberry cervix and Thick, white, “cottage cheese” discharge
Candida vulvovaginitis
What makes one more prone to Candida infections?
DB, Antibiotic use, douches, pregnancy
Diff in pH b/w Bact vaginosis, Trichomonas, and Candida
Normal pH in Candida
pH>4.5 in the other two
Which of the TORCHES infections more commonly spreads via delivery > pregnancy?
HSV2
Parvo B19 causes what in utero?
hydrops fetalis
Sx of Toxoplasma in mom/baby? Mode of maternal transmission?
Cat feces or ingestion of undercooked meat
Maternal - Usually asymptomatic; lymphadenopathy (rarely)
Neonate - Classic triad: chorioretinitis, hydrocephalus, and intracranial calcifications, +/− “blueberry muffin” rash
Rubella - MoT? Maternal Sx? Neonate Sx?
Respiratory droplets
Maternal - Rash, lymphadenopathy, polyarthritis, polyarthralgia
Neonate - Classic triad: abnormalities of eye (cataracts B) and ear (deafness) and congenital heart disease (PDA); ± “blueberry muffin” rash. “I (eye) ♥ ruby (rubella) earrings”
CMV - MoT? Maternal Sx? Neonate Sx?
Sexual contact, organ transplants
Maternal - Usually asymptomatic; mononucleosis-like illness
Neonate - Hearing loss, seizures, petechial rash, “blueberry muffin” rash, chorioretinitis, periventricular calcifications C
HIV - MoT? Maternal Sx? Neonate Sx?
Sexual contact, needlestick
Maternal - Variable presentation depending on CD4+ cell count
Neonate - Recurrent infections, chronic diarrhea
HSV2 - MoT? Maternal Sx? Neonate Sx?
Skin or mucous membrane contact
Maternal - Usually asymptomatic; herpetic (vesicular) lesions
Neonate - Meningoencephalitis, herpetic (vesicular) lesions
Syphilis - MoT? Maternal Sx? Neonate Sx?
Sexual contact
Maternal - Chancre (1°) and disseminated rash (2°) are the two stages likely to result in fetal infection
Neonate - Often results in stillbirth, hydrops fetalis; if child survives, presents with facial abnormalities (eg, notched teeth, saddle nose, short maxilla), saber shins, CN VIII deafness
Present with rashes of palms and soles
TSST of S aureus
Syphilis
Rocky Mountain Spotted Fever
Coxsackie A
Oval-shaped vesicles on palms and soles A; vesicles and ulcers in oral mucosa
Coxsackievirus type A Hand-foot-mouth disease
Asymptomatic rose-colored macules appear on body after several days of high fever; can present with febrile seizures; usually affects infants
Human herpesvirus 6
Roseola (exanthem subitum)
Confluent rash beginning at head and moving down; preceded by cough, coryza, conjunctivitis, and blue-white spots on buccal mucos
Measles virus
Measles (rubeola)
Coxsackie A - what family? DNA/RNA? What type? Envelope?
Picorna
SS+ linear RNA
Naked
Icosahedral capsid
HHV6 - family? envelope? DNA/RNA?
dsDNA linear, enveloped, Herpes family
Measles virus - Family? DNA/RNA? envelope?
Paramyxo; -SS linear enveloped, helical capsid
Parvovirus - enveloped? DNA/RNA?
ss linear DNA naked virus
Pink macules and papules begin at head and move down, remain discrete –> fine desquamating truncal rash; postauricular lymphadenopathy
Rubella
Rubella - family? DNA/RNA? envelope?
Togaviridae
SS+ linear RNA enveloped, icosahedral capsid
Flushed cheeks and circumoral pallor on face; erythematous, sandpaper-like rash from neck to trunk and extremities; fever and sore throat
S. pyogenes
S pyogenes -
Catalase +/-?
what type of hemolysis?
sensitive to what?
Catalase neg
Beta hemolytic
Bacitracin sensitive
Vesicular rash begins on trunk; spreads to face and extremities with lesions of different stages
VZV
Neonatal conjuctivitis - 1-2 days. Nonpurulent watery discharge.
Chemical - Irritation from antibiotic ointment.
Neonate - 2-5+ days. Hyperacute conjunctivitis, marked conjunctival injection, lid swelling, profuse purulent discharge. Rapid corneal involvement may be blinding. May disseminate.
Gonorrhea
Neonatal conjunctivitis - 5-14 days. Most common etiology. Mild to severe hyperemia, thick mucopurulent discharge, possibly bloody.
Chlamydia
Neonatal conjunctivitis - Days to 6 weeks. Conjunctival injection, nonpurulent discharge; keratitis, vesicular skin lesions, disseminated infection.
HSV
Painful genital ulcer with exudate, inguinal adenopathy
H. ducreyi chancroid
Urethritis, cervicitis, epididymitis, conjunctivitis, reactive arthritis, PID
Chlamydia trachomatis (D–K)
Genital warts, koilocytes
Condylomata acuminata
HPV 6, 11
Painful penile, vulvar, or cervical vesicles and ulcers; can cause systemic symptoms such as fever, headache, myalgia
HSV2 (HSV1)
Urethritis, cervicitis, PID, prostatitis, epididymitis, arthritis, creamy purulent discharge
Neisseria gonorrhoeae
Painless, beefy red ulcer that bleeds readily on contact
Granuloma inguinale
Klebsiella (Calymmatobacterium) granulomatis
What are Donovan bodies?
macrophages that are large and vacuolated centrally - bipolar staining - in Klebsiella granulomatis
Infection of lymphatics; painless genital ulcers, painful lymphadenopathy (ie, buboes
Lymphogranuloma venereum
C trachomatis (L1–L3)
Vaginitis, strawberry cervix, motile in wet prep
Trichomonas vaginalis
most common bacterial STI in the United States
Chlamydia trachomatis
cervical motion tenderness, adnexal tenderness, purulent cervical discharge
C trachomatis PID
infection and inflammation of liver capsule and “violin string” adhesions of peritoneum to liver
Fitz-Hugh–Curtis syndrome - perihepatitis
Most common causes of nosocomial infections
E coli (UTI) and S aureus (wound infection) are the two most common causes.
Watery diarrhea, leukocytosis rel to Antibiotic use, pathogen? Tx?
C. Diff , Metronidazole
Right lower lobe infiltrate or right upper/ middle lobe (patient recumbent); purulent malodorous sputum - disease? cause?
Aspiration pneumonia
Polymicrobial, gram ⊝ bacteria, often anaerobes
Decubitus ulcers, surgical wounds, drains - puts one at risk for infections with?
S aureus (including MRSA), gram ⊝ anaerobes (Bacteroides, Prevotella, Fusobacterium
Intravascular catheters - pathogens?
S aureus (including MRSA), S epidermidis (long term), Enterobacter
New infiltrate on CXR, Inc sputum production; sweet odor in pt wtih mech ventilations
Pseudomonas
Pt with mech ventilators are also at risk for?
Klebsiella, Acinetobacter, S aureus
Urinary Cath infection - pathogens?
Proteus spp, E coli, Klebsiella (infections in your PEcKer)
Disease assoc with water aerosols?
Legionella
Two rashes that affect unvacc children?
Rubella, Measles
3 pathogens that can lead to neuro sx in unvacc children?
H influ
Polio
C. tenani
Fever with dysphagia, drooling, and difficulty breathing due to edematous “cherry red” epiglottis; “thumbprint sign” on x-ray in unvacc child
H. influ type B
Low-grade fevers, coryza, inspiratory stridor, post-tussive vomiting in unvacc child
Bordetella Pertussis
grayish membrane on throat, that bleeds when disturbed in unvacc child
C. diphteriae
Asplenic patients
Encapsulated microbes, especially SHiN (S pneumoniae >> H influenzae type b > N meningitidis
Branching rods in oral infection, sulfur granules
Actinomyces israelii
Chronic granulomatous disease
Catalase ⊕ microbes, especially S aureus
“Currant jelly” sputum
Klebsiella
Dog or cat bite
Pasteurella multocida
Facial nerve palsy (typically bilateral)
Borrelia burgdorferi (Lyme disease)
Sinus/CNS infection in diabetics
Mucor or Rhizopus spp.
Neutropenic patients
Candida albicans (systemic), Aspergillus
Organ transplant recipient
CMV
PAS ⊕
Tropheryma whipplei (Whipple disease)
Pediatric infection
Haemophilus influenzae (including epiglottitis)
Pneumonia in cystic fibrosis, burn infection
Pseudomonas aeruginosa
Puncture wound, lockjaw
Clostridium tetani
Pus, empyema, abscess
S aureus
Rash on hands and feet
Coxsackie A virus, T pallidum, R rickettsii
Sepsis/meningitis in newborn
Group B strep
Surgical wound
S aureus
Traumatic open wound
Clostridium perfringens