Random antibodies + tests Flashcards

1
Q

Anti-mitochondrial antibody

A

Primary biliary cirrhosis

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2
Q

p-ANCA

A

Ulcerative colitis

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3
Q

Ham test

A

Paroxysmal nocturnal hemoglobinuria

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4
Q

anti-GAD

A

T1DM

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5
Q

anti-smooth muscle antibody

A

autoimmune hepatitis

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6
Q

Osmotic fragility test

A

hereditary spherocytosis

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7
Q

anti-endomysial antibodies

A

coeliac disease

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8
Q

anti-scl70 antibody

A

Diffuse scleroderma

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9
Q

anti-dsDNA antibodies

A

SLE

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10
Q

c-ANCA

A

wegener’s granulomatosis

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11
Q

Anti-Ro

A

Sjogren’s
SLE
Mixed CTD

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12
Q

Anti-nuclear

A

Connective tissue disease (includes anti-dsDNA)

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13
Q

Anti-mitochondrial

A

Primary Biliary Cirrhosis

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14
Q

anti-PCD

A

Esp SCLC

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15
Q

anti-CCP

A

Rheumatoid arhtritis

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16
Q

Anti-Acetylcholine receptor

A

Myasthenia gravis

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17
Q

anti-TTG

18
Q

Anti-endomysial antibody

A

Coeliac, Dermatitis Herpetiformis

19
Q

anti-smooth muscle antibodies

A

Autoimmune hepatitis

20
Q

cANCA

A

Wegener’s granulomatosis

21
Q

pANCA - name 2

A
  1. Churg Strauss

2. Microscopic Polyangitis

22
Q

anti-GBM

A

Goodpasture’s

23
Q

Anti-intrinsic factor

A

Pernicious anaemia

24
Q

anti-sm antibody

25
anti-phospholipid antibody
anti-phospholipid syndrome...
26
anti-cardiolipin antibody
Anti-phospholipid syndrome
27
Heterophiles antibody
Infectious mononucleosis
28
Anti-microsomal antibody
Hashimoto's thyroiditis
29
Anti-TPO antibody
Hashimoto's thyroiditis
30
TSH receptor antibody
Grave's disease
31
Anti-Jo1 antibody
Dermatomyositis
32
DNA topoisomerase I antibody
Diffuse scleroderma
33
Anti-centromere antibody
CREST syndrome
34
anti-ribonucleoprotein antibody
Mixed CTD | SLE
35
Anti-platelet antibody
ITP
36
antibodies vs GpIIb-IIIa
autoimmune thrombocytopenia purpura
37
Cells important in T1DM
CD8+ T cells attack beta cells
38
What happens in sensitisation (before full blown anaphylaxis)
Ag recognised by CD4 + Th2 cells and they release IL4 and IL13 This stimulates B cells to make IgE
39
Multiple sclerosis - important antigens?
Myelin basic protein + proteolipid protein
40
Polyarteritis nodosa is associated with which virus in 30% of cases
Hep B
41
Patch testing
Contact dermatitis
42
Latex fixation test
Rheumatoid factor