Immuno - case studies Flashcards
2 types of latex allergy
Type I - spectrum of severity from wheeze + urticaria –> anaphylaxis
Type IV - CONTACT DERMATITIS
Immediate management of anaphylaxis - 7 points
- Airway management
- O2
- IM adrenaline 500mcg
- IV fluids
- IV chlorpeniramine +
- hydrocortisone
- Inhaled salbutamol
Specific pt groups at risk of Type I allergy to latex
PREM
Indwelling latex devices (eg for hydrocephalus)
Multiple urological proedures
Why is tropical fruit allergy significant in latex allergy
Cross reactivity
Eg of latex containing products in healthcare setting
BP cuff Gloves Catheters Face masks Bandages Steth
For which allergens is desensitisation actually useful? state 2
Insect venom
Grass pollen
Disorders associated with recurrent meningococcal meningitis
Complement deficiency
Antibody deficiency
Any disruption to BBB
What kinda infections make you suspicious of an immunodeficiency?
SPUR Serious Persistent Unusual Recurrent
Suspected complement deficiency - what Ix are ordered?
C3
C4
CH50
AP50
Complement components in classical pathway
C1
C2
C4
Complement components of the alternate pathway
Factor B H I (from bacterial cells wall)
Complement components of the final common pathway
C5-9
Normal C3
Normal C4
Absent CH50
Absent AP50
What does this indicate?
Deficiency in final common pathway
Tests to investigate lupus nephritis?
Urinalysis (proteinuria + haematuria)
urine microscopy - red cells + casts
Renal biopsy
SLE - what kinda hypersensitivity disorder is it?
Type III: immune complex mediated
antinuclear antibodies bind to bare cells. these complexes activate complement + attract WBCs
wtf is adalimumab
humanised anti-TNFalpha
MOA of cyclophosphamide?
Which cells are most affected
Alkylates guanine
- affects B cells>T cells
Rituximab - which cells does it deplete?
mature B cells (but not plasma cells)
MMF - which cells does it affect?
T cells>B cells
Azathioprine - which cells does it affect
T cells