Microbio - viral hepatitis Flashcards

1
Q

Which hep virus is DNA?

A

HBV

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2
Q

Hepatitis A virus - time course? how can this be identified in blood?

A

Usually acute - leads to raised anti-HAV IgM

anti-HAV IgG is raised if previous infection or vaccinated

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3
Q

Transmission of HAV/HBV/HCV/HEV?

A
HAV = FO route
HBV = Sexual, vertical, blood products
HCV = blood products (rarely sexual)
HEV = FO route
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4
Q

Mx of HAV?

Incubation period for HAV?

A

2-6 weeks incubation period

Tends to last 3 weeks and is treated supportively

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5
Q

HBV infection - time course?

A

Acute OR chronic if lasts >6 months

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6
Q

How is HBV infection identified?

A

presents of HBVsurface Ag

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7
Q

LFTs in HBV infection?

A

ALT ++, AST +

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8
Q

3 drugs used for chronic HBV infection

A

pegIFNalpha
Lamivudine
Tenofovir

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9
Q

How is the liver affected in chronic HBV and HCV infection?

A

Fibrosis –> cirrhosis –> HCC

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10
Q

Incubation period of HBV

A

2-6 MONTHS

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11
Q

HCV - time course?

A

80% chronic!!!!! rest are acute

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12
Q

How is HCV diagnosed and why?

A

Can’t use anti-HCV antibody, as its levels only rise AFTER the event.

thus monitor HCV viral levels + ALT

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13
Q

what kind of virus is hCV?

A

flavivirus

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14
Q

How is IFN given and administered for HCV infection?

A

Pegylated IFN

Given once a week as depot injection

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15
Q

new treatment for HCV? what are its benefits?

A

SVR12

Oral treatment that is IFN free with a short tx course!

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16
Q

HEV - describe the diff genotypes?

A

Genotypes 1 and 2 = human

3 and 4 = swine

17
Q

Risk factors for HEV infection

A

uncooked pork and shellfish consumption, blood products

18
Q

HEV - high prevalence in which country?

Time course?

A

India + acute!

19
Q

To whom is HEV particularly dangerous

A

pregnant women –> high mortality!

20
Q

Mx of HEV?

A

supportive, unless chronic (?ribavirin)