Radiobiologically equivalent regimes Flashcards

1
Q

What is the α/β for Generic Early Reacting tissue?

A

10

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2
Q

What is the α/β for Generic Late Reacting tissue?

A

3

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3
Q

What is the α/β for Early Reacting Head & Neck tissue?

A

10

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4
Q

What is the α/β for Late Reacting Head & Neck tissue?

A

3 (non-CNS)

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5
Q

What is the α/β for Early Reacting CNS tissue?

A

10

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6
Q

What is the α/β for Late Reacting CNS tissue?

A

2

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7
Q

What is the α/β for Early Reacting NSCLC tissue?

A

10

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8
Q

What is the α/β for Late Reacting NSCLC tissue?

A

4.5

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9
Q

What is the α/β for Early Reacting Cervix tissue?

A

14

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10
Q

What is the α/β for Late Reacting Cervix tissue?

A

3

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11
Q

What is the α/β for Early Reacting Breast tissue?

A

10

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12
Q

What is the α/β for Late Reacting Breast tissue?

A

3

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13
Q

What is the α/β for Early Reacting Prostate tissue?

A

1.5-5

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14
Q

What is the α/β for Late Reacting Prostate tissue?

A

3

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15
Q

What does the radiobiological value ‘k’ represent?

A

‘dose’ loss per day once treatment exceeds TDelay (time from commencing treatment until onset of rapid re-population)
It is sometimes given the units of ERD/day.

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16
Q

What is the Generic radiobiological k value?

17
Q

What is the H&N radiobiological k value?

A
  1. 1 if T<28

0. 9 if T>28

18
Q

What is the CNS radiobiological k value?

A
  1. 1 if T<28

0. 9 if T>28

19
Q

What is the NSCLC radiobiological k value?

A
  1. 1 at start

0. 9 at end

20
Q

What is the Cervix radiobiological k value?

21
Q

What is the Breast radiobiological k value?

22
Q

What is the Prostate radiobiological k value?

23
Q

What is the Generic Tdelay value?

24
Q

What is the H&N Tdelay value?

A

0 if T<28

28 if T>28

25
What is the CNS Tdelay value?
0 if T<28 | 28 if T>28
26
What is the Breast Tdelay value?
35
27
Which radiobiological terms can be used for comparing different fractionation regimes?
EQDX, EQD2, BED
28
What are the consequences of improved outcomes leading to increased survival?
Increased probability that patients will: - experience relapse (original tumour) - develop a new primary tumour - require future palliative care
29
What is the limiting factor of any future treatments for patients that have had radiotherapy?
The total OAR doses (though repair is taken into account usually with BED)
30
What literature is used for guidance on management of gaps? What guidance is included?
``` Management of Gaps, 2008, RCR. Guidance on techniques: - Accelerated treatments - multiple fractions per day - weekend catch up ```
31
When would additional dose or a modified regime be required?
If there was a gap in treatment that took T to over the limit of Tdelay.
32
What is the minimum time recommended between fractions, and why? Where does this come from?
>6 hours. This allows normal tissue repair. | The value comes from RCR Guidelines 2008.