R2 LOCO3 Flashcards
Which species of your normal skin flora:
Makes up 90% of the flora? [1]
Is found in nose, perineum, vulvar skin? [1]
Feeds off sebum and cellular debris and colonisation starts when sebaceous glands become more active?
Makes up 90% of the flora: Staphylococcus epidermidis
Is found in nose, perineum, vulvar skin: Staphylococcus aureus
Feeds off sebum and cellular debris and colonisation starts when sebaceous glands become more active: Propionibacterium acnes
Which pathogen causes hot tub folliculitis? [1]
Pseudomonas aeruginosa
Treatment for folliculitis? [3]
Oral antibiotic
Retinoic acid & Vit. A: reduces amount of sebum
Two primary pathogens that cause impetigo? [2]
Staphylococcus aureus or Streptococcus pyogenes
Tx of impetigo?:
Simple cases [1]
Severe cases? [1]
Most people? [1]
Oral or topical antibiotic for severe cases that have spread to other body areas
NICE recommends 1% hydrogen peroxide cream for simple cases
But most people will get better without treatment within 3 weeks
What is cellulitis in the face called? [1]
How does it differ to cellulitis in location? [1]
Most common pathogen? [1]
Erysipelas (cellulitis of the face) but just in the dermis and not in subcutaneous fat
Streptococcus pyogenes
What is this skin infection? [1]
Which pathogen causes this? [1]
Scalded skin syndrome:
Staphylococcus aureus
Describe the pathophysiology of scalded skin syndrome [2]
Exotoxins are proteases that destroy desmosomes holding keratinocytes in granulosum and spinosum layers together:
Causes widespread fluid filled blisters that easily break
Treatment of scalded skin syndrome? [2]
Treatment:
* Conservative: rehydration antipyretics
* Parenteral antibiotics
What is Nikolsky sign and what does it test? [1]
Nikolsky sign is a test of how weak the blister is.
Pencil eraser placed on top of blister and turned if blister ruptures the blister is intraepidermal. Or you turn the eraser on unblistered skin and new blister forms.
Therapy for Necrotising fascitis? [3]
Treatment:
* Surgical debridement
* Empiric antibiotics
* Hyperbaric oxygen (Add on therapy)
Describe pathophysiology of HPV causing warts and verrucas [3]
DNA virus
Infects basal cells of the epidermis
Lesions arise from proliferation of infected basal keratinocytes
Causes hyperkeratosis, acanthosis and hypergranulosis, rete ridge elongation and large blood vessels at dermoepidermal junction
Treatment for HPV: viral warts and veruccas? [5]
Topical salicylic acid
Fluorouracil cream
Cryosurgery
Surgical curettage
Laser treatment (CO2 laser 582nm)
Describe the pathophysiology of Pityriasis versicolour [1]
Which populations does it impact more? [1]
Overgrowth of commensal yeast Pityrosporum orbiculare; young adults, brown/pink scaly patches, hypopigmented if suntanned
Affects young adults and slightly more men than women:
It is not contagious infection is not due to poor hygiene usually occurs in warmer months white, salmon or light brown patches chest,back, arms and legs
More common in hot humid climates and only affects people that sweat heavily
Often clears during the winter months and reappears each summer
Treatment of Pityriasis versicolour (tinea versicolour)? [3]
- Antifungal shampoo (ketoconazole)
- Selenium sulphide (off-label)
- For small areas antifungal creams
Describe what Postherpetic neuralgia (PHN) is [2]
Unpredictable complication of varicella zoster virus- (VZV-) induced herpes zoster (HZ) which often occurs in elderly and immunocompromised persons
The main symptom of post-herpetic neuralgia is intermittent or continuous nerve pain in an area of your skin previously affected by shingles.
Leprosy is caused by which pathogens? [2]
Mycobacterium leprae or mycobacterium lepromatosis
Treatment for leprosy? [3]
Rifampicin, dapsone and clofazimine
The femoral head recieves blood supply from which arteries? [3]
State the source of each of these arteries [2]
Medial and lateral circumflex arteries, from profunda femoris
Acetabular branch of obturator artery
Which type of prosthetic material has a narrower stem
Cemented
Uncemented
Cemented