Muscle histology Qs Flashcards
Duchenne MD patients are likely to suffer from
Restrictive cardiomyopathy
Dilated cardiomyopathy
Arrhythmogenic cardiomyopathy.
Hypertrophic obstructive cardiomyopathy
Dilated cardiomyopathy
Fibromyalgia
IBM
Which of the following statements is true regarding the skeletal muscle biopsy image shown above?
CD20+ B cells are the predominant inflammatory component
CD8+ T cells are the predominant inflammatory component
Histologic findings are classic for dermatomyositis
IVIG is the first line therapy
Presence of rimmed vacuoles favors polymyositis
B. CD8+ T cells are the predominant inflammatory component
Infantile myopathy: Most fibres are small and round with a few massively hypertrophic fibres
This histological slide supports a diagnosis of
Body inclusion myositis
Duchenne MD (early)
Duchenne MD (late)
Myositis
Infantile myopathy
Fibromyalgia
Myositis - CD8 cell infiltration
This histological slide supports a diagnosis of
Body inclusion myositis
Duchenne MD (early)
Duchenne MD (late)
Myositis
Infantile myopathy
Fibromyalgia
Myositis
This histological slide supports a diagnosis of
Body inclusion myositis
Duchenne MD (early)
Duchenne MD (late)
Myositis
Infantile myopathy
Fibromyalgia
Body inclusion myositis: Congo red stain - amyloid plaques
This histological slide supports a diagnosis of
Body inclusion myositis
Duchenne MD (early)
Duchenne MD (late)
Myositis
Infantile myopathy
Fibromyalgia
Body inclusion myositis: empty vacuole
This histological slide supports a diagnosis of
Body inclusion myositis
Duchenne MD (early)
Duchenne MD (late)
Myositis
Infantile myopathy
Fibromyalgia
Body inclusion myositis
This histological slide supports a diagnosis of
Body inclusion myositis
Duchenne MD (early)
Duchenne MD (late)
Myositis
Infantile myopathy
Fibromyalgia
Duchenne MD (early)
*Fibre size variability
*Endomysial fibrosis
*Degenerating muscle fibres undergoing myophagocytosis
This histological slide supports a diagnosis of
Body inclusion myositis
Duchenne MD (early)
Duchenne MD (late)
Myositis
Infantile myopathy
Fibromyalgia
Duchenne MD: Endomysial connective tissue: Increased between muscle fibers
This histological slide supports a diagnosis of
Body inclusion myositis
Duchenne MD
Myositis
Infantile myopathy
Fibromyalgia
Duchenne MD: Dystrophin staining (Below): Muscle fibers in preserved fascicle are revertants with dystrophin present around their rim
Some revertant muscle fibers are present in myopathic regions as well.
This histological slide supports a diagnosis of
Body inclusion myositis
Duchenne MD
Myositis
Infantile myopathy
Fibromyalgia
Duchenne MD:
Later loss of muscle
Atrophy of fibres and death of fibres
Replaced with fibrotic material and fat
This histological slide supports a diagnosis of
Body inclusion myositis
Duchenne MD
Myositis
Infantile myopathy
Fibromyalgia
Duchenne MD:
Later loss of muscle
Atrophy of fibres and death of fibres
Replaced with fibrotic material and fat
This histological slide supports a diagnosis of
Body inclusion myositis
Duchenne MD
Myositis
Infantile myopathy
Fibromyalgia
BMI
This histological slide supports a diagnosis of
Body inclusion myositis
Duchenne MD
Myositis
Infantile myopathy
Fibromyalgia
Body inclusion myositis
This imaging supports a diagnosis of
Body inclusion myositis
Duchenne MD
Myositis
Sarcopenia
Fibromyalgia
Body inclusion myositis
This imaging supports a diagnosis of
Body inclusion myositis
Duchenne MD
Myositis
Sarcopenia
Fibromyalgia
Body inclusion myositis
This imaging supports a diagnosis of
Body inclusion myositis
Duchenne MD
Myositis
Sarcopenia
Fibromyalgia
Body inclusion myositis
This imaging supports a diagnosis of
Body inclusion myositis
Duchenne MD
Myositis
Sarcopenia
Fibromyalgia
Dermatomyositis / Myositis: calcification
What disease is most likely shown?
Sarcopenia
This imaging supports a diagnosis of? [1]
Infantile myopathic hypotonia
