NSAIDs Flashcards
Somatic / nociceptive pain is well localised except for when pain is occuring from which areas? [1]
When deep: in a joint:
* Muscle
* tendon
* ligament
* bone
* fascia
* joints
State Hilton’s law [1]
The nerve supplying a joint (capsule) also supplies the muscles that move the joint and the skin over the joint and the insertion of the muscles
Hip pain is referred to which location? [1]
Knee
State two drugs which are classified as strong [2] and weak [2] opiods
Strong opoids: morphine, oxycodone, fentanyl and buprenorphine
“Weak” opioid analgesics. Codeine, dihydrocodeine and tramadol: no less risky than morphine.
A 65-year-old man with metastatic prostate cancer to bone presents with bone pain. He has had no pain relief with aspirin. The clinician decides to choose a drug from the next level of the analgesic ladder. What is the most appropriate next drug on the WHO ladder for cancer pain relief in adults?
A. Methadone
B. Hydrocodone
C. Fentanyl
D. Morphine
B. Hydrocodone
What type of NSAID is indomethacin
Acetic acid derivative
Propoinic acid derivative
Selective COX-2 inhibitros
Salicylates
What type of NSAID is indomethacin
Acetic acid derivative
Propoinic acid derivative
Selctive COX-2 inhibitros
Salicylates
do more
What type of NSAID is diclofenac
Acetic acid derivative
Propoinic acid derivative
Selective COX-2 inhibitor
Salicylates
What type of NSAID is diclofenac
Acetic acid derivative
Propoinic acid derivative
Selctive COX-2 inhibitros
Salicylates
What type of NSAID is aspirin
Acetic acid derivative
Propoinic acid derivative
Selective COX-2 inhibitor
Salicylates
What type of NSAID is aspirin
Acetic acid derivative
Propoinic acid derivative
Selctive COX-2 inhibitros
Salicylates
What type of NSAID is ibuprofen
Acetic acid derivative
Propoinic acid derivative
Selective COX-2 inhibitor
Salicylates
Propoinic acid derivative
What type of NSAID is celecoxib
Acetic acid derivative
Propoinic acid derivative
Selective COX-2 inhibitor
Salicylates
Selective COX-2 inhibitor
What type of NSAID is naproxen
Acetic acid derivative
Propoinic acid derivative
Selctive COX-2 inhibitor
Salicylates
Propoinic acid derivative
State the role of COX-1 & COX-2 enzymes [4]
Take arachidonic acid and convert to prostaglandin G2
Prostaglandin G2 converts to Prostaglandin H2
PH2 then converted to tissue specific prostaglandins
Different prostaglandins are found in different tissues and have different effects.
Prostaglandins are local tissue hormones; made in the tissue where you need it
What therapeutic effects does aspirin have? [3]
analgesic, antipyretic, anti-inflammatory
Ibuprofen, diclofenac and ketoprofen have what therapeutic effects? [2]
analgesic and anti-inflammatory effects (not anti-pyretic)
Name two selective COX-2 inhibitors
Celecoxib
Etoricoxib
Meloxicam
Which is the most common NSAID prescribed in the UK?
celecoxib
diclofenac
ibuprofen
indomethacin
naproxen
naproxen