qs

Question 1

Sarcopenia is most likely to lead to?

OA
RA
Osteoporosis
Tendonosis
Osteomalacia

Answer 1

Osteoporosis

(chicken and egg with muscle and bone loss with sarcopenia and OP)

Question 2

RA

Which cell type is most common in synovial membrane? [1]
Which cell type is most common in synovial fluid? [1]

Answer 2

Synovial membrane: CD4 TH17 lymphocytes
Synovial fluid: Neutrophils

Question 3

Why are inflammatory diseases of the joint worse in the morning? [2]

Answer 3

Temporal relationship between elevated levels of pro-inflam cytokines and symptoms: IL-6 has close similiarity with daily RA symptoms

Elevated serum melatonin levels in RA patients: can stimulate production of IL-1; IL-6

Question 4

Which inflammatory cytokine is most associated with daily RA symptoms?

IL-1
IL-6
IL-8
IL-17
TNF-a

Answer 4

IL-6

Question 5

Name one of the most common presenting signs of RA? [1]

Answer 5

Carpel tunnel syndrome

Question 6

Describe two differences between ligaments and tendons [2]

Answer 6

Ligaments have more prosteoglycans and elastic fibres
Ligaments are more yellow

Question 7

Which Ig is deposited in SLE?

IgE
IgD
IgA
IgG
IgM

Answer 7

IgG

Question 8

genu varum
valgum above or below for osteotomy?