Quinolides

Question 1

mechanism of action

Answer 1

• destroys bacteria by changing bacteria’s DNA - interferes with the DNA GYRASE & TOPIOSOMERASE
• they DO NOT inhibit the production of human DNA
• often kill mostly GRAM-NEGATIVE and SOME GRAM-POSITIVE
• also called FLUROQUINOLONES

Question 2

indications of use

Answer 2

• often used to treat COMPLICATED UTIS
  
  • due to excretion primarily by the kidneys
• treatment for RESPIRATORY, SKIN, GI, BONE and JOINT INFECTIONS
• ex. utis, travelers diarrhea, diabetic foot infections, gonorrhea

Question 3

contraindications

Answer 3

drug allergy

Question 4

adverse effects

Answer 4

• can cause CARDIAC ISSUES; prolonged QT interval
• cardiac dysrhythmias
• not recommended for children; can cause issues in CARTILAGE DEVELOPMENT

increased risk for;
- TENDINITIS/TENDON RUPTURE
- in older adult patients
- PERIPHERAL NEUROPATHY
- CNS EFFECTS - seizures
- MYASTHENIA GRAVIS

Question 5

interactions

Answer 5

• antacids
• calcium/mag/iron/zinc
• dairy products
• enteral tube feedings
• warfarin

Question 6

ciprofloxacin

Answer 6

• oral, injectable
• drug of choice for TREATMENT OF ANTHRAX
• can also kill Chlamydia, Mycoplasma, Mycobacterium

Question 7

levofloxacin

Answer 7

• advantage of once-daily dosing
• oral, injectable
• excellent bioavailability - oral form
• varying indication of use

Question 8

what is the ANTIBIOTIC CHOICE OF TREATMENT for MRSA?

Answer 8

vancomycin
**this is within the GLYCOPEPTIDE CLASS; inhibits cell wall synthesis
can also help treat CDIFF
**works similar to AMINOGLYCOSIDES - needs specific drug levels to be considered safe