PUD Flashcards
Ulceration of the mucosa anywhere in the GI tract that is exposed to acid and pepsin
Peptic ulcer disease
What are the 2 common forms of PUD?
- Duodenal ulcer
- Gastric ulcer
What is the most common form of PUD?
Duodenal ulcer
What ages do duodenal ulcers usually occur?
Between ages 30-50
What ages are usually diagnosed with Gastric ulcers?
> 60 years
What are the 3 most common types of PUD?
- H. Pylori
- NSAID induced
- Stress related mucosal damage
True or false: cigarette smoking can help ease the pain caused by PUD
False
People who develop PUD tend to be more adversely affected by _____.
Stress
What 4 foods can cause dyspepsia but do not increase the risk of PUD?
- Coffee
- Tea
- Soda
- Spices
What is found in most people with duodenal and gastric ulcers?
H. Pylori
How is H. Pylori primarily spread?
Through fecal to oral route
What is the mechanism for H. Pylori causing PUD?
Catalyzes urea—> ammonia—> erodes mucus barrier—> epithelial damage
What 2 things does H. Pylori produce?
- Cytotoxins
- Mucolytic enzymes
NSAIDs are weak ___ and _______ at gastric pH
Acids; nonionized
What do NSAIDS decrease the production of?
Prostaglandins
Since prostaglandin production is decreased what 3 things can happen?
- Reduction in gastric and mucosal blood flow
- Decreased mucus and bicarbonate secretion
- Decrease cellular replication and repair
NSAID induced PUD is prevalent in what type of patients?
- Pts > 60
- Pts with a prior history of PUD
- Pts taking high dose NSAIDS
Concurrent administration with what 5 drugs can lead to NSAID induced PUD?
- Corticosteroids
- Anticoagulants
- Oral bisphosphonates
- Antiplatelet agents
- SSRIs
NSAID induced ulcers are often ____.
Silent