CINV Flashcards
What are 6 complications of CINV? (Left side)
- Electrolyte imbalances
- Dehydration
- Malnutrition/ anorexia
- Aspiration pneumonia
- Rib fractures
- Weight gain
What are 4 complications of CINV? (Right side)
- Increased intracranial pressure
- Mallory- Weiss tears
- Wound dehiscence
- Degeneration of self care/ functional status
What are 6 patient risk factors?
- Age <50 years
- Female gender
- Tumors in GI tract, mouth or brain
- History of GI distress, motion sickness or motion sickness
- Poor control of emesis with prior chemotherapy
- Multiple cycles of chemotherapy
What are 2 things that have a decreased risk for CINV?
- Chronic alcohol consumption
- Age > 50 years
What 4 things does emetogenic vary with?
- Drug
- Dose
- Infusion time
- Route of administration
What receives stimuli from the GI Tract?
CTZ
What receives stimuli from the GI Tract and CTZ?
Vomiting Center (VC)
What two centers control vomiting in the medulla?
- CTZ
- VC
What are the 3 NTs involved in CINV?
- Dopamine
- Serotonin
- Neurokinin
What are the 5 major types of CINV?
- Acute
- Delayed
- Breakthrough
- Anticipatory
- Refractory
CINV that peaks in 4-10 hours and resolves in 24 hours?
Acute
What is acute CINV mediated by?
Serotonin
Occurs 1-5 days after chemotherapy and can last 7-10 days after last chemotherapy
Delayed
What is Delayed CINV mediated by?
Dopamine
Nausea or emesis despite adequate prophylaxis
Breakthrough CINV
What does breakthrough CINV require?
Rescue antiemetics