IBD regimens Flashcards

1
Q

For Mild distal UC, what is first line therapy?

A

Topical aminosalicylates (enema/suppository)

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2
Q

For mild distal UC, If first line therapy doesn’t work, what should you try next?

A
  1. Oral aminosalicylate
    OR
  2. Topical corticosteroids
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3
Q

For mild distal UC what can be used for remission/maintenance?

A
  1. Mesalamine (enema or suppository) 3x/week
  2. Oral aminosalicylate to maintenance dose
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4
Q

For mild EXTENSIVE UC, what is used as first line therapy?

A
  1. Oral aminosalicylate
    OR
  2. Oral budesonide
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5
Q

For mild EXTENSIVE UC, if there’s no response to the first line therapy, what should you use?

A

Oral corticosteriod

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6
Q

For mild DISTAL UC, what can be used for remission/maintenance?

A

Oral aminosalicylate at maintenance dose

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7
Q

For moderate severe UC, what is used as first line? Per ACG

A
  1. Oral aminosalicylate
    OR
  2. Oral budesonide
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8
Q

For moderate severe UC, what can you use second line per ACG?

A

Systemic corticosteroids

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9
Q

For moderate severe UC, what can be used as an alternative per ACG?

A

Biologics: adalimumab, golimumab, infliximab

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10
Q

For moderate severe UC, what is used as first line therapy per AGA?

A

Biologics: infliximab, golimumab, adalimumab, vedolizumab

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11
Q

What are additional therapies for moderate severe UC that can be used per AGA?

A
  1. Tofacitinib
  2. Ustekinumab
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12
Q

For moderate severe UC, you can consider combining what?

A

TNF inhibitor, vedolizumab or Ustekinumab with a thiopurine

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13
Q

What can be used for remission/maintenance for moderate severe UC?

A
  1. Oral aminosalicylate at maintenance dose (if responded)
  2. Thiopurine (if due to corticosteroid induction)
  3. TNF inhibitor or other biologic
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14
Q

For severe fulminant UC, what is used as first line therapy?

A
  1. IV corticosteroids
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15
Q

If a patient doesn’t respond to the first line therapy of severe fulminant UC, what can be used?

A
  1. Infliximab
    OR
  2. IV cyclosporine
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16
Q

What can be used for remission/maintenance of severe fulminant UC?

A
  1. Oral prednisone (if responded to IV corticosteroids) + TNF inhibitor or biologic +/- thiopurine
  2. Infliximab at maintenance dose (if responded)
  3. TNF inhibitor or biologic +/- thiopurine (if responded to cyclosporine)