Monoclonal Antibodies

Question 1

What does avastin specifically bind to?

Answer 1

VEGF

Question 2

Avastin prevents VEGF-A from properly interacting with ______ receptor

Answer 2

VEGFR-2

Question 3

What does avastin cause an inhibition of?

Answer 3

Angiogenesis

Question 4

When new blood vessels form from pre-existing blood vessels

Answer 4

Angiogenesis

Question 5

When should you not administer avastin?

Answer 5

28 days before or after surgery

Question 6

What must a patient have to use trastuzumab?

Answer 6

HER2 overexpression

Question 7

What portion of trastuzumab blocks the signaling pathways of HER2?

Answer 7

Fc portion

Question 8

What does the fab portion of trastuzumab prevent?

Answer 8

HER2 dimerization

Question 9

What is the main side effect for trastuzumab?

Answer 9

Cardiotoxicity

Question 10

Radioactive tracer diagnostic test to evaluate the pumping function of the ventricles

Answer 10

MUGA

Question 11

Why is cardiotoxicity a SE of trastuzumab?

Answer 11

Because of Herceptin bind to the receptor on the heart leading to herceptin mediated destruction of cardiomyctes

Question 12

Which EGFR - has the higher risk of HSR?

Answer 12

Cetuximab

Question 13

What should you premedicate with for cetuximab?

Answer 13

Antihistamines

Question 14

What kind of -mab is cetuximab?

Answer 14

Chimeric

Question 15

What type of -mab is panitumumab?

Answer 15

Fully human mab

Question 16

What toxicity can be caused by any EGFR -?

Answer 16

Acne form rash

Question 17

Why do EGFRs cause their main toxicity?

Answer 17

Cause inflammatory cell infiltration leading to a skin rash

Question 18

What should you test a patients cancer cells for to use rituxan?

Answer 18

CD20

Question 19

What 3 things can rituxumab cause B-cells to do?

Answer 19

1. Complement system
2. Apoptosis
3. Antibody dependent cell mediated cytotoxicity

Question 20

What does rituxan non selectively destroy?

Answer 20

B cells with CD20

Question 21

What 3 types of B cells can rituxan destroy?

Answer 21

1. Overactive B cells
2. Dysfunctional B cells
3. Excess number of B cells

Question 22

What is CD20 absent on?

Answer 22

Lymphoid stem cells

Question 23

What is it called when the checkpoint inhibitors take advantage of the human immune system?

Answer 23

Checkpoint blockade

Question 24

What do the checkpoint inhibitors bind to on the T cell?

Answer 24

PD-1

Question 25

What do the checkpoint inhibitors bind to on the cancer cell?

Answer 25

PD-L1

Question 26

What can the checkpoint inhibitor monoclonal antibodies cause?

Answer 26

Drug induced autoimmune disease

Question 27

When the checkpoint inhibitors are injected, what do they bind to on T cells?

Answer 27

CTLA-1

Question 28

What are antibodies used for?

Answer 28

To neutralize a specific chemical substance

Question 29

What do antibodies recognize? How?

Answer 29

Antigens; Fab variable region

Question 30

Each tip of the Y of an antibody contains what?

Answer 30

Paratrope

Question 31

What region allows antibodies to communicate with other components of the immune system?

Answer 31

Fc

Question 32

What are murine monoclonal antibodies derived from?

Answer 32

Mouse

Question 33

True or false: patients can develop an allergic reaction from a mouse source

Answer 33

True

Question 34

What origins are chimeric antibodies a mix of?

Answer 34

Mouse (Fc) and human (Fab)

Question 35

Which monoclonal antibodies are the most human?

Answer 35

-umab

Question 36

Which monoclonal antibodies carry the lowest risk of triggering an immunogenic or allergic response?

Answer 36

-Umab