Monoclonal Antibodies Flashcards
What does avastin specifically bind to?
VEGF
Avastin prevents VEGF-A from properly interacting with ______ receptor
VEGFR-2
What does avastin cause an inhibition of?
Angiogenesis
When new blood vessels form from pre-existing blood vessels
Angiogenesis
When should you not administer avastin?
28 days before or after surgery
What must a patient have to use trastuzumab?
HER2 overexpression
What portion of trastuzumab blocks the signaling pathways of HER2?
Fc portion
What does the fab portion of trastuzumab prevent?
HER2 dimerization
What is the main side effect for trastuzumab?
Cardiotoxicity
Radioactive tracer diagnostic test to evaluate the pumping function of the ventricles
MUGA
Why is cardiotoxicity a SE of trastuzumab?
Because of Herceptin bind to the receptor on the heart leading to herceptin mediated destruction of cardiomyctes
Which EGFR - has the higher risk of HSR?
Cetuximab
What should you premedicate with for cetuximab?
Antihistamines
What kind of -mab is cetuximab?
Chimeric
What type of -mab is panitumumab?
Fully human mab
What toxicity can be caused by any EGFR -?
Acne form rash
Why do EGFRs cause their main toxicity?
Cause inflammatory cell infiltration leading to a skin rash
What should you test a patients cancer cells for to use rituxan?
CD20
What 3 things can rituxumab cause B-cells to do?
- Complement system
- Apoptosis
- Antibody dependent cell mediated cytotoxicity
What does rituxan non selectively destroy?
B cells with CD20
What 3 types of B cells can rituxan destroy?
- Overactive B cells
- Dysfunctional B cells
- Excess number of B cells
What is CD20 absent on?
Lymphoid stem cells
What is it called when the checkpoint inhibitors take advantage of the human immune system?
Checkpoint blockade
What do the checkpoint inhibitors bind to on the T cell?
PD-1
