Public Health Sciences Flashcards
cross sectional study
frequency of disease and risk-related factors
measures prevalence
case control study
odds ratio
cohort sutdy
given exposure
results in relative risk
can be prospective or retrospective
twin concordance study
frequency with which both monozygotic and dizygotic twins
measures heritable and influence of environmental factors
phase I clinical trial
is it safe
phase II
does it work-efficacy, dosing, and adverse effects
phase III
compares new to current standard of care
phase IV
adverse effects
PPV and NPV
depend on disease prevalence
sensitivity
true positive
rules out disease
good for screening
specificity
low false positive rate
used for confirmation
rules in
high pretest probability
high PPV
low NPV
lowering cutoff
increase FP and decreases FN
N (sensitivity and NPV increase)
raising cutoff
increase FN and decreases FP
P (specificity and PPV increase)
likelihood ratio
can be multiplied with pretest odds of test to estimate posttest odds +>10 and <0.1
number needed to treat
1/ARR
low number means better treatment
number needed to harm
1/AR (diff subtraction than ARR)
incidence
new cases
prevalence and disease duration
incidence(duration)=prevalence
precision
reliability
absence of random variation
increases statistical power (1-beta)
accuracy
validity
trueness of test measurement
systemic error decreases accuracy in a test
selection bias
nonrandom sampling
berkson
from hospital-less healthy
non-response bias
participating subjects differ from nonrespondents
hawthorne effect
participants change their behavior in response to awareness of being observed
pygmalion effect
researcher belief in efficacy changing outcome
reduction of confounding bias
multiple studies crossover studies matching restriction randomization
reduction of lead-time bias
measure back-end survival
standard error
decreases and number increases
positive skew
mean>median>mode