public health Flashcards
phase 1
phamocokindynamic, pharmokinetic
phase2
asses the efficacy, dosing and adverse effect of the treatment
phase3
compares the new treatment currnet treatment. is it better?
phase4
detects rare or longterm adverse effects
cross-sectional study
frequency o disease and frequency of risk related factors, eg. disease prevalence
no comparison
case-control study
compares group of diseased to those without disease
cohort study
compares a group with a given exposure or risk to a group without exposure
cohort= rel. risk
cross study
compares the effect of a series of 2 or more treatments on participant, randomized treatment, washout period, allows participants to serve as their own contol
sensitivity
true positive rate TP/(TP+FN)
=1-FN rate
specifity
true negative rate TN/TN(TN+FP)=
1-FP rate
odds ratio
OR=a/c:b/b/d=ad:bc
relative risk
RR=a/(a+b):c/(c+d)
correct result
there is an effect
null hypotheses h0
no difference
alternative h1
there is a difference