Psych - Substance Abuse + Addiction Flashcards

1
Q

What drugs can cause substance addiction?

A
• Alcohol
• Nicotine
• Cannabis
• Stimulants
– Amphetamine 
– Cocaine
• Crack 
– Ecstasy
• Opioids (prescribed, OTC)
– Heroin, fentanyl
– DF118
• Ketamine
• Solvents
• GHB, GBL
• Benzodiazepines 
• Psychedelics
– LSD, Magic mushrooms • Nitrous oxide
• Khat
• ‘Novel psychoactive substances’
– ~950 synthetic (UNODC);
– new: ~1/wk
– Categories:
• Depressant, stimulant, hallucinogenic. cannabinoid
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2
Q

Why do people take recreational drugs?

A
  • reduce anxiety
  • get high
  • boredom
  • stay awake
  • to fit in
  • rebel
  • escapism
  • like it
  • to get to sleep
  • why not
  • feel better
  • everyone does
  • curious
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3
Q

What is positive reinforcement?

A

action taken to gain a positive state

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4
Q

What are examples of positive reinforcement that fuel addiction?

A
  • escapism
  • get high
  • stay awake
  • like it
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5
Q

What is negative reinforcement?

A

action taken to overcome adverse states

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6
Q

What are examples of negative reinforcement that fuel addiction?

A
  • boredom
  • to get to sleep
  • reduce anxiety
  • feel better
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7
Q

What is the course of addiction or drug abuse? *

A
• "LIKE" : Experimental/‘recreational’ use, causes no/limited difficulties - (majority of population)
• "WANT" :
Increasingly regular use (fewer people)
• "NEED" :
Spiralling, dependence (smaller number)
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8
Q

What is the definition of harmful substance use?

A

Actual damage should have been caused to the mental or physical health of the user in the absence of diagnosis of dependence syndrome

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9
Q

What is the progression from “like” to “want” to “need called?

A

neuroadaptations

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10
Q

What is the prevalence of alcohol dependence?

A

– 595, 000 estimated prevalence
– 103,471 in treatment
– approx. 82% of adults in need of specialist treatment for alcohol not receiving it.

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11
Q

What is the prevalence of opiate dependence?

A

– 257,476 estimated prevalence
– 170,032 in treatment
– ~46% of adults in need of specialist treatment for opiates not receiving it
– Death rates rising from opiates and from cocaine

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12
Q

What is the definition of addiction?

A

compulsive drug use despite harmful consequences, characterized by an inability to stop using a drug; failure to meet work, social, or family obligations; and, (depending on the drug) tolerance and withdrawal

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13
Q

What is dependence?

A

refers to a physical adaptation to a substance
– Tolerance/withdrawal
so can be dependent and not addicted

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14
Q

What are some examples of behavioural addictions?

A

– internet gaming disorder

– gambling disorder

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15
Q

Why was gambling reclassified as a behavioural addiction from ‘impulse control disorder’ previously?

A

Many similarities in aetiology, neurobiology and treatment

approaches, as well as comorbidity, with substance dependence

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16
Q

What is hazardous substance use?

A

likely to cause harm if it continues at this level

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17
Q

Phil drinks four pints of Stella most evenings. Says his drinking doesn’t cause problems. What issue may he have?

A

Hazardous Use:

– quantity + frequency is too high

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18
Q

Jenny drinks a bottle of wine most evenings, more at the weekends. Occasionally misses work
because of hangovers. What issue may she have?

A

Harmful Use:
– negative consequences
– Physical, Psychological, Social impact
– Eg Missing work due to hangovers

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19
Q

Tom drinks cider first thing each morning to stop himself shaking. Regards drink as a medicine,
believes he wouldn’t get by without it. Doesn’t tend to get drunk. What is the issue?

A

Dependence / Addiction:
– Tolerance and morning drinking to relieve
– withdrawal are signs of dependence.

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20
Q

Katie broke her ankle 6 months ago which healed well and is back to playing football. Is still taking her
opioid painkillers which are on repeat prescription. Is there an issue?

A

Likely biologically dependent as has been taking opioids for many months; no evidence of taking more than is
prescribed (ie suggesting ‘abuse’) however need to ask if this
is the case and why it is on repeat – has it just happened through error/lack of review or has she requested it?

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21
Q

Samson Broke his ankle 3 months ago and says he is still in pain. Is still taking his opioid painkillers and often
requests his prescription earlier. Is there an issue?

A

Likely biologically dependent as has been taking opioids
for many months; is taking more than is prescribed so need to
ask why – for pain or to deal with withdrawal or ‘likes how it makes him feel’. Consider harmful use, ask about any other addiction behaviours to clarify if addicted

22
Q

Adam broke his ankle 4 months ago and is still taking his opioid painkillers, often requests his prescription earlier, is also taking up to 12 Neurofen plus tablets/day, uses alcohol and cannabis to help him sleep and has not gone back to work.

A

Likely biologically dependent as has been taking opioids
for many months; is taking more than is prescribed and buying
extra as well as using other drugs – highly likely to be addicted

23
Q

How does brain entry affect addiction?

A

faster brain entry = more “rush” and more addiction

24
Q

What elements are involved in alcohol / drug interactions?

A

– social / environmental factors
– drug factors
– personal factors e.g. genetic, personality traits

25
Q

What is the brain pathway for drug use to addiction?

A

– pre-existing vulnerbaility + family history + age
– drug exposure + compensatory neuroadaptations to maintain brain function
– recovery sustained or cycles of remission and relapse

26
Q

What is the brain pathway for alcohol use to addiction?

A

– pre-existing vulnerbaility + family history + age
– drug exposure + compensatory neuroadaptations to maintain brain function
– why drink?, tolerance, withdrawal

27
Q

Why are we compelled to drink alcohol?

A

– Alcohol alters the balance between brain’s inhibitory and excitatory system

28
Q

How does acute alcohol affect the excitatory system?

A

– blocks the NMDA receptors, blocking the system

– impaired memory (alcoholic blackouts)

29
Q

How does acute alcohol affect the inhibitory system?

A

– boosts inhibitory system

e. g. Anxiolysis
e. g. Sedation

30
Q

How does chronic alcohol exposure effect the excitatory system?

A

up regulation of the excitatory system

31
Q

How does chronic alcohol exposure affect the inhibitory system?

A

– reduced function in inhibitory system - tolerance

– GABA-A receptors switch in subunits to make them less sensitive to alcohol

32
Q

How is the absence of alcohol affect the excitatory + inhibitory system?

A

– complete withdrawal with no balance in GABA and glutamate
– up regulation of excitatory system
– NMDA receptor: increase in Ca2+ = toxic
– leads to hyper-excitability (seizures) + cell death (atrophy)

  • reduced function in the inhibitory system
33
Q

How is the withdrawal state from alcohol treated?

A

– Benzodiazepines (boosts GABA function + reduces glutamate)
– Acamprosate (helps people remain abstinent + reduces NMDA function)
–Naltrexone – opioid antagonist – to block heroin use in opioid addicts and to modulate reward system in alcoholism

34
Q

What are some common examples of benzodiazepines?

A

– lorazepam

– diazepam

35
Q

What are the 3 main models of addiction?

A

– reward deficiency (positive reinforcement)
– impulsivity / compulsivity
– overcoming adverse state e.g. withdrawal, anxiety (negative reinforcement)

36
Q

How does the dopamine relate to addiction?

A
natural rewards (e.g. sex, food) and certain drugs (e.g. opioids) increases levels of dopamine in the Ventral Striatum
this dopamine pathway = "pleasure-reward-motivation" pathway
37
Q

How do drugs such as cocaine, amphetamine, opiates, etc. relate to dopamine?

A

– cocaine + amphetamine block dopamine reuptake from he synapses
– amphetamine enhances release of DA
– other drugs of abuse eg alcohol, opiates, nicotine increase dopamine neuron firing in VTA (ventral segmental area)

38
Q

What is addiction often conceptualised as?

A

reward deficient state

39
Q

Who are vulnerable to addiction?

A

adolescents are vulnerable to problematic drug use due to reward deficient states

40
Q

What make abstinent addicts more likely to relapse physiologically?

A

more blunted response in brain to anticipation of rewards

41
Q

What are the different stages of addiction?

A

– binge / intoxication
– withdrawal / negative affect
– preoccupation / anticipation (craving)

42
Q

What regions of the brain are involved in the “binge / intoxication” stage?

A

– Dorsal Striatum

– Thalamus

43
Q

What regions of the brain are involved in the “withdrawal / negative effect” stage?

A

brain stem + hypothalamus

44
Q

What regions of the Brian are involved in the “preoccupation / anticipation / craving” stage?

A

prefrontal cortex
hippocampus
Basolateral amygdala
insula

45
Q

How does positive or negative reinforcement change as addiction progresses?

A

– positive reinforcement decreases after a small rise

– negative reinforcement increases as positive reinforcement decreases, and it continues to increase

46
Q

What stage + regions of the brain are target for treatment?

A

– withdrawal + negative emotional states
– reward system : reduced dopamine and mu opioid function + stress system : increased activity in many including kappa opioid (dynorphin), noradrenaline (arousal system) CRF (stress) should be targeted
– dysregulation in amygdala is key

47
Q

How is addiction in the brain studied and assessed?

A

through fMRI + stimulation

48
Q

What does the amygdala’s response look like for abstinent polydrug addicts and abstinent alcoholics?

A

– nothing different in alcoholics

– left amygdala has heightened brain response for polydrug addicts

49
Q

How does the brain transition when drug use changes from voluntary to habitual?

A

• prefrontal to striatal control
over drug taking
– i.e. prefrontal ‘top-down’ control is diminished with greater striatal reward drive
• ventral (limbic or emotional) to dorsal (habit) striatum.
– big role for hippocampus in the craving aspect

50
Q

How is neurocircuitry assessed in inhibitory control?

A

– fMRI + go, no-go task

– assessing putamen and inferior frontal gyrus

51
Q

What is the relationship between brain response + alcohol abstinence?

A

Greater response in frontal pole/inferior frontal gyrus during inhibiting response in abstinent alcoholics:
greater response associated with longer abstinence