Gastro - Appetite Flashcards
What are the 3 mechanisms through which thirst is regulated?
→ body fluid osmolality
→ blood volume is reduced
→ blood pressure is reduced
Which of the mechanisms is most potent?
→ plasma osmolality
→ change of 2-3% induces strong desire to drink
→ decrease of 10-15% in blood volume or arterial pressure is required to produce the same
What regulates osmolality?
ADH (anti-diuretic hormone) or vasopressin
What does ADH do?
acts on kidneys to regulate volume + osmolality of urine
Where in the kidneys does ADH act?
collecting duct, aquaporin 2 channel
How does low plasma ADH affect urine volume?
large volume of urine is excreted (water diuresis)
How does high plasma ADH affect urine volume?
small volume of urine is excreted (anti diuresis)
What receptors detect osmolality?
osmoreceptors
What are osmoreceptors?
Sensory receptors
Osmoregulation
Found in the hypothalamus
Where are osmoreceptors found?
in hypothalamus:
→ Organum vasculosum of the lamina terminalis (OVLT)
→ Subfornical Organ (SFO)
How do osmorecepetors stimulate ADH release?
→ Cells shrink when plasma more concentrated
→ Proportion of cation channels increases – membrane depolarizes
→ Send signals to the ADH producing cells to increase ADH
→ Fluid retention, Invokes drinking
How do osmorecepetors inhibit ADH release?
→ Cells are turgid/normal when plasma less concentrated
→ Proportion of cation channels decreases – membrane hype-polarises
→ No signals are sent to ADH producing cells, so ADH stays low
How is the sensation of thirst satisfied?
→ decreased by drinking even before sufficient water has been absorbed by the GI tract to correct plasma osmolality
→ Receptors in mouth, pharynx, oesophagus are involved
→ Relief of thirst sensation via these receptors is short lived.
→ Thirst is only completely satisfied once plasma osmolality is decreased or blood volume or arterial pressure corrected
Where is ADH stored?
posterior pituitary
What change in BP triggers the renin-angiotensin-aldosterone system?
decrease in blood pressure
What happens when BP decreases?
decrease in blood pressure causes JUXTAGLOMERULAR CELLS of renal afferent arterioles to produce RENIN
What does renin do?
renin is an enzyme that converts:
angiotensinogen —> angiotensin I
in the liver
What does angiotensin I do?
gets converted into angiotensin II by ACE in the lungs
What does angiotensin II cause?
→ vasoconstriction, increase in sympathetic activity
→ ADH secretion
→ H2O retention via Na+CL- absorption + K+ excretion
→ causes aldosterone to be released
→ Thirst
What else can stimulate aldosterone release?
increased potassium, decreased sodium levels
How is aldosterone released via angiotensin II? From where?
→ angiotensin II binds to intraglomerular messenger cells
→ cells contract + blood vessels around them contract
→ causes aldosterone to be released form zone glomerulosa of adrenal cortex
What does aldosterone do?
H2O retention via Na+CL- absorption + K+ excretion
What medications have an impact on the RAAS pathway?
→ ace inhibitors
→ direct renin inhibitors
Who studied body homeostasis in the 20th century?
→ Neuman 1902 – his weight was stable for a long time despite no conscious effort to balance out intake and expenditure
→ Passmore 1971 – most individual adults maintain a relatively stable weight over long periods
What does a reduction in fat mass result in?
increased food intake + reduced energy expenditure
What does adipose tissue expansion cause?
reduced food intake + increased energy expenditure
What systems are activated when weight is augmented? What is the result?
→ increased sympathetic nervous system activity
→ increased energy expenditure
→ decreased hunger/food intake
this all results in weight loss
What systems are activated when weight is reduced? What is the result?
→ decreased sympathetic nervous system activity
→ decreased energy expenditure
→ increased hunger/food intake
this all results in weight gain
What system mainly defend against the reduction of body fat?
central circuit
What system defends against rapid expansion?
yet to be discovered
What part of the body regulates appetite?
hypothalamus
What stimulants are necessary for hypothalamus to regulate appetite?
→ GHRELIN, PYY + other gut hormones
→ neural input from the periphery + other brain regions
→ LEPTIN