Psych - Psychosis Flashcards

1
Q

What is psychosis?

A

difficulty perceiving and interpreting reality

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2
Q

What disorders can cause psychosis?

A
→ schizoaffective disorder
→ bipolar I
→ depression with psychotic features
→ due to other medical condition
→ substance-related
→ schizophrenia (1%)
→ delusional disorder
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3
Q

What are the symptom domains fo psychosis?

A

→ positive symptoms
→ negative symptoms
→ disorganisation

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4
Q

What are some positive symptoms of psychosis?

A

→ hallucinations

→ delusions

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5
Q

What are the features of psychotic hallucinations?

A
percepts in absence of a stimulus
• Auditory
• Voices commenting on you
• Voices talking to each other
• Visual
• Somatic/tactile
• Olfactory (rare)
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6
Q

What are the features of psychotics delusions

A
Fixed, false beliefs, out of keeping with social/cultural background
• Persecutory
• Control
• Reference
• Mind reading
• Grandiosity
• Religious
• Guilt/sin
• Somatic
• Thought broadcasting
• Thought insertion
• Thought withdrawal
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7
Q

What are the negative symptoms of psychosis

A
→ alogia
→ anhedonia
→ abolition / apathy
→ affective flattening
→ associality
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8
Q

What is alogia?

A

→ poverty of speech
→ paucity of speech, little content
→ slow to respond

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9
Q

What is avolition or apathy?

A

→ poor self-care
→ lack of persistence at work / education
→ lack of motivation

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10
Q

What is anhedonia or asociality?

A

→ few close friends
→ few hobbies or interests
→ impaired social functioning

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11
Q

What is affective flattening?

A
→ unchanging facial expression
→ few expressive gestures
→ poor eye contact
→ lack of vocal intonations
→ inappropriate affect
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12
Q

What are disorganisation symptoms in psychosis?

A

→ bizarre behaviour

→ thought disorder

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13
Q

What are features of bizarre behaviour?

A
• Bizarre social behaviour
• Bizarre clothing/appearance
• Aggression/agitation
• Repetitive/stereotyped
behaviours
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14
Q

What are features of thought disorder?

A
  • Derailment
  • Circumstantial speech
  • Pressured speech
  • Distractibility
  • Incoherent/illogical speech
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15
Q

What is the average onset of psychosis?

A

→ can occur at any age
→ peak incidence in adolescence or early 20s
→ peak later in women

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16
Q

What is the course of psychosis like?

A

→ often chronic + episodic

→ very variable

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17
Q

What is the morbidity of psychosis like?

A

→ Substantial, both from disorder itself and increased risk of common health problems e.g. heart disease
→ Significant impact on education, employment and functioning

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18
Q

What are the rates of mortality in psychosis?

A

→ substantial
→ all-cause mortality = 2.5x higher
→ 15 years of life expectancy lost
→ high risk of suicide in schizophrenia with 28% excess mortality

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19
Q

When taking a psychiatric history for psychosis, what do you look for?

A
  • History of Presenting Concern
  • Past Psychiatric History
  • Background History (Family, Personal, Social)
  • Past Medical History and Medicines
  • Corroborative History
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20
Q

What do you look for in History of Presenting Concern?

A
  • patient’s description of the presenting problem – nature, severity, onset, course, worsening factors, treatment received
  • Circumstances leading to arrival to hospital
  • WHY NOW?
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21
Q

What do you look for in Past Psychiatric History?

A
  • Any known diagnosis?
  • Any treatment?
  • Known to a community team?
  • Any previous admissions to hospital?
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22
Q

What do you look for in Background + Family History?

A
  • Age of parents, siblings, relationship with them
  • Atmosphere at home
  • Mental disorder in the family, abuse, alcohol/drugs misuse, suicide
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23
Q

What do you look for in Personal History?

A
  • Mother’s pregnancy and birth
  • Early development, separation, childhood illness
  • Educational and occupational history
  • Intimate relationships
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24
Q

What do you look for in Social History?

A
  • Living arrangements
  • Financial issues
  • Alcohol and illicit drug use
  • Forensic History
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25
Q

What do you look for in Past Medical History + Medicines?

A
  • Regular medications?
  • Compliance?
  • Over the counter medications?
  • Interactions?
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26
Q

What do you look for in Corroborative History?

A

after gaining consent:
• Informants: relatives, friends, authority
• Confidentiality

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27
Q

What is examined broadly in a Mental State Examination?

A
  • Appearance and Behaviour
  • Speech
  • Mood
  • Thoughts
  • Perceptions
  • Cognition
  • Insight
28
Q

What do you look for in appearance + behaviour?

A
  • General appearance
  • Facial expression
  • Posture
  • Movements
  • Social behaviour
29
Q

What are the major red flags in General Appearance?

A
  • NEGLECT : alcoholism, drug addiction, dementia, depression, schizophrenia
  • WEIGHT LOSS : anorexia nervosa, depression, cancer, hyperthyroidism, financial issues/homelessness
30
Q

What do you look for in Facial Expressions?

A
  • depressive
  • anxious
  • wooden, Parkinsonian
31
Q

What do you look for in Posture?

A
depressive
• hunched shoulders
• downcast head + eyes
anxious
• sitting upright
• head erect
• hands gripping the chair
32
Q

What do you look for in movements?

A
  • overactive, restless – manic
  • inactive, slow - depressive
  • immobile, mute – stupor
  • tremors, tics
  • choreiform movements
  • dystonia
  • tardive
  • dyskinesia mannerisms
  • stereotypes
33
Q

What do you look for in social behaviours?

A
  • disinhibited
  • overfamiliar withdrawn
  • preoccupied
  • signs of impending violence: raised voice
  • clenching fists
  • pointed fingers
  • intrusion into personal space
34
Q

What do you look for when observing Speech?

A
  • Quantity : less, more, mutism
  • Rate : slow, fast, pressure of speech
  • Spontaneity : latency
  • Volume : quiet or loud
35
Q

What do you look for when observing Mood?

A

• Subjective Mood
• Objective Mood
- Predominant mood
- Constancy : emotional lability / incontinence reduced / reactivity / blunting / flattening / irritability
- Congruity : cheerful while describing sad events

36
Q

What do you look for when looking at Thoughts?

A
• Stream
• Form
• Content
- Preoccupations
- Morbid thoughts, suicidality 
- Delusions, overvalued ideas - Obsessional symptoms
37
Q

What is looked for in terms of delusions?

A
  • primary – occurs suddenly
  • secondary – arises from previous abnormal idea / experience (hallucination / mood / delusion)
  • folie à deux : delusional mood / perception / memory shared delusion
38
Q

What is looked for in terms of overvalued ideas?

A
  • paranoid of reference
  • grandiose/ expansive
  • guilt / worthlessness
  • hypochondriacal
  • jealousy
  • sexual/ amorous
  • religious
  • control
  • concerning the possession of thought (insertion, withdrawal, broadcast)
39
Q

What are obsessional symptoms to look for in psychosis?

A
  • obsessional thoughts: dirt and contamination, aggressive actions, orderliness, disease, sex, religion
  • compulsions: checking, cleaning, counting, dressing rituals
40
Q

What do you look for in patient perceptions?

A
  • Illusions
  • Hallucinations
  • Distortions
41
Q

What is an illusion?

A

misperception of a real external stimulus

42
Q

What is a hallucination?

A

perception in the absence of external stimulus

43
Q

What are the 2 subsets of hallucinations?

A

1) true perception

2) coming from outside the head

44
Q

What are the different types or features of hallucinations?

A
  • hypnagogic : transitional state of consciousness between wakefulness and sleep
  • hypnopompic : occur in the morning as you’re waking up
  • auditory : second person, third person
  • visual : Charles Bonnet syndrome
  • olfactory
  • gustatory
  • tactile, of deep sensation
45
Q

What is Charles Bonnet syndrome?

A

a person whose vision has started to deteriorate to see things that aren’t real

46
Q

What are the different aspects of Cognition?

A
  • Consciousness
  • Orientation
  • Attention and concentration • Memory
  • Language functioning
  • Visuospatial functioning
47
Q

What kind of insight is witnessed in psychosis?

A

• Awareness of oneself as presenting phenomena that other people consider abnormal
• Recognition that these phenomena are abnormal
• Acceptance that these abnormal phenomena are caused by mental
illness
• Awareness that treatment is required
• Acceptance of the specific treatment recommendations

48
Q

What are the management options for psychosis?

A
  • pharmacological
  • psychological
  • social support
49
Q

What is involved in psychological management for psychosis?

A
  • CBT for psychosis

* newer therapies like avatar therapy

50
Q

What is involved in social support for those with psychotic disorders?

A
  • supportive environments, structures + routines
  • housing + benefits
  • support with budgeting + employment
51
Q

What kind of drugs are antipsychotics usually?

A
  • Dopamine Antagonists

* some partial agonists

52
Q

Why aren’t dopamine agonists used?

A
  • increased dopamine activity is implicated in causing reality distortion
  • evidence = elevated presynaptic dopamine in striatum
53
Q

What is an example of a partial agonist used to treat psychosis?

A

Aripiprazole (less effective though)

54
Q

What are the side effects of antipsychotics (dopamine antagonists)?

A
  • Parkinsonism
  • Acute Dystonia
  • Tardive Dyskinesia
  • Akathisia
55
Q

What is Parkinsonism?

A
  • Rigidity - characteristic ‘cog-wheeling’
  • Slow and shuffling gait
  • Lack of arm swing in gait – early sign
  • ‘pill-rolling’ tremor - slow (4-6Hz) movement of the thumb across the other fingers
56
Q

What is dystonia?

A
  • Increased motor tone -> sustained abnormal posture
  • Can occur shortly after taking dopamine antagonist
  • Can be acute, frightening, painful, even fatal (laryngeal dystonia)
57
Q

What is tardive dyskinesia?

A
  • Repeated oral/ facial/ buccal/ lingual movements
  • Initially subtle – can progress to tongue involvement, lip smacking
  • Increased risk: long-term antipsychotics, female
58
Q

What is akathisia?

A
• Inner restlessness
• Feel compelled to move, but does little to alleviate
• Can lead to overt, relentless
movement
• Legs most commonly affected
59
Q

Why do these side effects occur?

A

Antipsychotics can cause post- synaptic dopamine blockade in the extra-pyramidal system

60
Q

What is the extrapyramidal system?

A

parts of the brain that enable us to maintain posture and tone

61
Q

What is an atypical antipsychotic?

A

less likely to cause extrapyramidal side effects

62
Q

What is a typical antipsychotic?

A

commonly causes extrapyramidal side effects

63
Q

What is an example of an atypical antipsychotic?

A

olanzapine

64
Q

How are EPSEs managed?

A

• Avoid them in the first place:
atypical antipsychotics usually
first-line
• Change medication
• Anticholinergic medications can help e.g. procyclidine
• Patients need to be fully-informed about risks

65
Q

What are some other side effects of antipsychotics?

A
  • sedation
  • agranulocytosis
  • neutropenia
  • increased appetite
  • weight gain
  • diabetes
  • dysrhythmia
  • long QTc
  • increased prolactin (release surpassed by dopamine so)
  • constipation
66
Q

What is involved in long-term management of psychosis?

A
  • Community follow-up
  • Managing antipsychotic side effects e.g. weight, diabetes
  • Health promotion: reducing risk factors e.g. smoking, diet