Protein Degradation- Lecture 10/20/21 Flashcards
1
Q
Ammonia production
A
Mostly by bacteria acting on urea
2
Q
Nitrogen carriers in blood (4)
A
- Ammonia (can be toxic)
- Urea
- Uric acid (from purine breakdown)
- Creatinine
3
Q
Whichnotrogen carrier concentration changes in response to changes in diet?
A
Urea
4
Q
Positive Nitrogen balance (3)
A
- Growth
- Pregnancy
- Muscle building
5
Q
negative nitrogen balance (3)
A
- Trauma
- Low dietary proteins
6
Q
Amino transferase
A
Transfers NH3 group to alphaketoglutarate, generates a keto acid
7
Q
Vitamin B6
A
PLP, needed for aminotransferase
8
Q
Glutamate dehydrogenase
A
Generates Ammonia in mitochondria of liver using NAD+
9
Q
Glutaminase
A
Turns glutamine to glutamate and ammonia
10
Q
Asparaginase
A
Turns asparagine to aspartate
11
Q
Three ways to dispose of ammonia
A
- Make urea (major)
- Make glutamine
- Make glutamate (glu dehydrogenase in reverse)
12
Q
Carbamoyl phosphate
A
The entrance to the urea cycle
