Alcohol- Lecture 9/21/21

Question 1

Prevalence of alcoholism

Answer 1

1 in 8 americans

Question 2

Peak BAC

Answer 2

About 45 minutes after drinking

Question 3

Factors that influence BAC curves (6)

Answer 3

How many drinks
Your sex
Your basal metabolic index
Your emetic background
Alcohol consumption history
Co-consumption

Question 4

Affect of fatty food

Answer 4

Slows gastric transport and hence absorption

Question 5

Rate of elimination of alcohol after drinking

Answer 5

Clear about 1 drink per hour

Question 6

Alcohol dehydrogase

Answer 6

Uses NAD+ to oxidize alcohol to acetaldehyde

Question 7

Acetaldehyde

Answer 7

Associated with many symptoms of a hangover

Question 8

ADH1B*2

Answer 8

Variant high in Asian populations, has a much higher Vmax

Question 9

Microsomal ethanol oxidizing system (MEOS)

Answer 9

Occurs in the smooth OR, activated among chronic alcohol users

Question 10

Cytochrome p450

Answer 10

Oxidizes ethanol to acetaldehyde

Question 11

Aldehyde dehydrogenase 2

Answer 11

Uses NAD+ to oxidize acetaldehyde further to acetic acid

Question 12

Acetyl CoA synthetase

Answer 12

Takes acetate and makes acetyl-CoA, hence energy

Question 13

Alcohol consumption effect on NADH

Answer 13

Increases NADH/NAD+ ratio, can reduce gluconeogenesis, increases lactic acid formation

Question 14

Wernicke’s Encephalopathy

Answer 14

C confusion
O Ophthalmopegia
A Ataxia
T thiamine Tx

Question 15

Korsakoff’s psychosis

Answer 15

R Retrograde amnesia (lose old, keep new)
A anterograde amnesia (lose new, old intact)
C Confabulations
K orsakoff’s psychosis

Question 16

Methanol

Answer 16

Metabolism leads to formate, can cause blindness/poisoning

Question 17

Fomeprizole

Answer 17

Inhibitor of ADH