Prostaglandin Derivatives

Question 1

Leukocyte chemotaxis

Answer 1

Eicosanoid: LTB4

G-Protein: Gq

Question 2

Bronchoconstriction, slow-reacting substance of anaphylaxis

Answer 2

Eicosanoid: LTC4 | LTD4

G-Protein: Gq | Gq Gi

Question 3

Vascular smooth muscle relaxation, protective effects on gastric mucosa, maintains PDA

Answer 3

Eicosanoid: PGE1

G-Protein: Gs Gq

Question 4

Vascular smooth muscle relaxation, maintains PDA, increase uterine tone

Answer 4

Eicosanoid: PGE2

G-Protein: Gs Gq

Question 5

Vascular smooth muscle relaxation (peripheral, pulmonary, coronary)

Answer 5

Eicosanoid: PGI2

G-Protein: Gs

Question 6

Increases uterine tone, decreases IOP

Answer 6

Eicosanoid: PGF2a

G-Protein: Gq

Question 7

Platelet aggregation

Answer 7

Eicosanoid: TXA2

G-Protein: Gq

Question 8

Analogue: PGE1

Clinical use: Erectile dysfunction

Answer 8

Alprostadil

Question 9

Analogue: PGE1

Clinical use: NSAID induced gastritis

Answer 9

Misoprostol

Question 10

Analogue: PGF2A

Clinical use: Chronic glaucoma

Answer 10

Latanoprost

Question 11

Analogue: PGE2

Clinical use: Abortifacient

Answer 11

Dinoprostone

Question 12

Analogue: PGF2A

Clinical use: Abortifacient

Answer 12

Carboprost

Question 13

Analogue: PGI2

Clinical use: Pulmonary hypertension

Answer 13

Epoprostenol