Hematologic Agents

Question 1

Treatment of Iron deficiency anemia

Answer 1

Ferrous Sulfate

Hematopoietic growth factors

Question 2

Treatment of megaloblastic anemia, vitamin B12 deficiency

Answer 2

Cyanocobalamin

Hematopoietic growth factors

Question 3

Treatment of megaloblastic anemia, prevention of neural tube defects (spina bifida)

Answer 3

Folate / Folic Acid

Hematopoietic growth factors

Question 4

Anemia in chronic kidney disease

Answer 4

Erythropoietin

Hematopoietic growth factors

Question 5

Treatment of neutropenea and agranulocytosis

Answer 5

Filgrastim

Hematopoietic growth factors

Question 6

Treatment of chemotherapy induced thrombocytopenia

Answer 6

Oprekelvin

Hematopoietic growth factors

Question 7

Acute treatment of DVT, PE, and AMI

SE: bleeding, thrombocytopenia, monitor with PTT

Answer 7

Heparin

Anticoagulants

Question 8

Low molecular weight heparin, less risk of thrombocytopenia, does not need monitoring

Answer 8

Enoxaparin

Anticoagulants

Question 9

Treatment of Heparin-induced thrombocytopenia

Answer 9

Lepirudin

Anticoagulants

Question 10

Antidote to Heparin-induced bleeding

Answer 10

Protamine Sulfate

Question 11

Chronic coagulation

SE: bleeding, skin necrosis, many drug interactions

Answer 11

Warfarin

Question 12

Antidote to warfarin (immediate reversal)

Answer 12

FFP

Question 13

Antidote to warfarin (reversal overtime)

Answer 13

Vitamin K

Question 14

What Laboratory tests will ypu request to assess the extrinsic and intrinsic coagulation pathways?

Answer 14

PTT: Intrinsic pathway
PT: Extrinsic pathway

Question 15

in patient requiring anticoagulation, why is an overlap between heparin and warfarin usually done?

Answer 15

1. Warfarin’s effect requires elimination of preformed clotting factors (8 - 60h)
2. to bypass the initial prothrombotic effect of Warfarin (skin necrosis)

Question 16

Thrombolysis in AMI, ischemic CVD and PE

SE: bleeding

Answer 16

Alteplase

Thrombolytic agents

Question 17

Bacteria-derived thrombolytic, decreased effect on subsequent uses due to antibody formation

Answer 17

Streptokinasee

Thrombolytic agents

Question 18

Antidote to thrombolytic overdose

Answer 18

Aminocaproic Acid

Thrombolytic agents

Question 19

Irreversible COX inhibitor, instant prevention of arterial thrombosis
SE: tinnitus, hypersensitivity, Reye Syndrome

Answer 19

Aspirin

Antiplatelet drugs

Question 20

ADP inhibitor, additive effects with Aspirin

Answer 20

Clopidogrel

Antiplatelet drugs

Question 21

Glycoprotein IIb-IIIa inhibitor

Answer 21

Abciximab

Antiplatelet drugs

Question 22

Phosphodiesterase inhibitor, cardiac stress testing

Answer 22

Dypirimadole

Antiplatelet drugs

Question 23

What is the triad of aspirin hypersensitivity?

Answer 23

SAMTER TRIAD: Asthma, Aspirin Hypersensitivity, and Nasal Polyp

Question 24

What are the signs of ASA poisoning?

Answer 24

Coma
Hyperventilation
Acidosis
Fever
Seizure

Question 25

What is the expected acid-base abnormality in salicylate poisoning?

Answer 25

Respiratory Alkalosis with HAGMA

Question 26

What is the difference between in presentation of aspirin intoxication in children and adults?

Answer 26

Adults: mixed based disorder, respiratory Alkalosis with HAGMA

CHILDREN: pure acid-base disorder HAGMA

Question 27

What is the difference between an inhibitor and an uncoupler of oxidative phosphorylation?

Answer 27

Inhibitors: completely halt ETC
Uncouplers: dissipate proton gradient without interrupting ETC