Anti-Neoplastic Agents

Question 1

Alkylating agent

used for treatment of lymphomas

SE: hemorrhagic cystitis
Rescue agent: Mesna

Answer 1

Cyclophosphamide

MOA: forms DNA cross links, inhibit DNA synthesis and function

Question 2

Alkylating agent used for lymphoma (MOPP)

SE: marked vesicant actions (skin blistering)

Answer 2

Mechlorethamine

MOA: forms DNA cross links, inhibit DNA synthesis and function

Question 3

Alkylating agent

treatment of colon cancer

SE: ototoxicity, nephrotoxicity
Rescue Agent: Amifostine

Answer 3

Cisplatin

Carboplatin

Question 4

Alkylating agent

used for lymphoma

SE: disulfiram reaction, Leukemogenesis

Answer 4

Procarbazine

Question 5

Alkylating agent

used for testicular and ovarian tumor
Most specific for the G2 phase

SE: pulmonary fibrosis, Bone marrow sparing

Answer 5

Bleomycin

Question 6

Alkylating agent

used for treatment of brain tumor

SE: CNS toxicity

Answer 6

Carmustine

Question 7

Anti-metabolite

used for the treatment of Lymphomas and GTN

SE: myelosuppression, pulmonary fibrosis
Rescue agent: Leucovorin (Folinjc acid)

Answer 7

Methotrexate

Question 8

Anti-metabolite

used for treatment of Acute Leukemias

SE: myelosuppression, hepatotoxicity, metabolism inhibited by allopurinol

Answer 8

6-Mercaptopurine

Question 9

Anti-metabolite

used for the treatment of colorectal and skin cancer, causes thymine-LESS death of cells

SE: Myelosuppression

Answer 9

5-Flourouracil

Question 10

Anti-metabolite

used for the treatment of CML in blast crisis
Most specific for the S phase of the cell cycle

Answer 10

Cytarabine

Question 11

Anti-metabolite

It inhibits ribonucleotide reductase
treatment of Pancreatic Cancer

Answer 11

Gemcitabine

Question 12

Plant derivative

Vinca alkaloid
prevents microtubule assembly

SE: peripheral neuropathy

Answer 12

Vincristine

Question 13

Plant derivative

Podophyllotoxin
inhibits DNA topoisomerase II
treatment of Lung Cancer, non-hodgkin’s lymphoma and GTN

Answer 13

Etoposide

Question 14

Plant derivative

Camptothecin
It inhibits DNA topoisomerase I
treatment of small cell lung cancer

Answer 14

Topotecan

Question 15

Plant derivative

Taxane
It prevents microtubule DISassembly
Used advanced breast and ovarian cancers

Answer 15

Paclitaxel

Question 16

Anti-tumor Antibiotics

used as an intercalating agent

SE: dilated cardiomyopathy
Rescue agent: Dexrazoxane

Answer 16

Doxorubicin

Adriamycin

Question 17

Anti-tumor Antibiotics

used for the treatment of melanoma, Wilms tumor, and GTN

Answer 17

Actinomycin D

Question 18

Anti-Neoplastic - Tyrosine kinase inhibitor, treatment of CML
SE: fluid retention; multiple drug interactions

Answer 18

Imatinib

Question 19

Anti-Neoplastic

used for the treatment of metastatic breast cancer, active against cells expressing HER-2/neu

Answer 19

Trastuzumab

Question 20

Anti-Neoplastic

inhibits VEGF
treatnebt of metastatic cancers

Answer 20

Bevacizumab

Question 21

Anti-Neoplastic

used for differentiation therapy
treatment of acute promyelocytic leukemia
only vitamin that can cure cancer

Answer 21

All Trans Retinoic acid

Question 22

ANTI-NEOPLASTIC

M-phase

Answer 22

Vinblastine
Vincristine
Paclitacxel

Question 23

ANTI-NEOPLASTIC

G2 phase

Answer 23

Bleomycin

Question 24

ANTI-NEOPLASTIC

S phase

Answer 24

CHEM 66

Cytarabine
Hydroxyurea
Etoposide
Methotrexate
6-mercaptopurine
6-thioguanine

Question 25

ANTI-NEOPLASTIC

Topoisomerase II inhibitor
G1-S phase

Answer 25

Etoposide

Question 26

RESCUE drug for

Cyclophosphomide: hemorrhagic cystitis

Answer 26

MESNA

Question 27

RESCUE drug for

Doxorubicin: cardiotoxicity

Answer 27

Dexrazoxane

Question 28

RESCUE drug for

Cisplatin/ Carboplatin
-nephrotoxicity and ototoxicity

Answer 28

Amifostine

Question 29

RESCUE drug for

Methothrexate/ myelosuppression

Answer 29

Leucovorin