Antidepressants Flashcards
Tricyclic antidepressant
MOA: inhibit REUPTAKE of NE and Serotonin
treatment of enuresis
SE: atropine-like effects, cardiotoxicity
Imipramine
Amitriptiline
Clomipramine
Desipromine
Selective serotonin teuptake inhibitor (SSRI)
first line drug for major depressive disorder
SE: erectile dysfunction, serotonin syndrome, CYP450 inhibitor
Fluoxetine
Escitalopram
Paroxetine
Sertraline
Serotonin-Norepinephrine reuptake inhibitor (SNRI)
SE: hypertension, CYP450 inhibitor
Venlafaxine
Duloxetine
Serotonin antagonist
SE: priapism
Trazodone
Metazodone
Nefazodone
Tetracyclic antidepressant
smoking cessation
SE: weight loss, priapism, seizures
Bupropion
Monoamine oxidase inhibitor
SE: hypertensive crisis when taken with tyramine, serotonin syndrome
Phenelzine
What are the feature of TCA overdose?
Toxic dose: 7mg/kg
Lethal: 15mg/kg
3 Cs of TCA Overdose
Coma
Convulsions
Cardiotoxicity
What drugs can cause erectile dysfunction?
a SORE PEniS can’t Fuck Hard
SSRIs
Opiates
Risperidone
Ethanol
Propranolol
Estrogens
Spinorolactone
Finasteride
Hydrochlorothiazide
What drugs can cause priapism?
Tigas PeniS Qu, AyaW Bumaba!
Trazodone
Papaverine
Sildenafil
Quetiapine
Alprostadil
Warfarin
Bupropion
Symptoms of serotonin syndrome
FAT CHD
Fever
Agitation
Tremor
Clonus
Hyperreflexia
Diaphoresis
DOC for malignant hyperthermia
Dantrolen
DOC for serotonin syndrome
Sedation
Paralysis
Intubation and ventilation
DOC for neuroleptic malignant syndrome
Diphenhydramine
S/sx of malignant hyperthermia?
FARTCH
Fever Acidosis Rhabdomyolysis Trismus Clonus Hypertension
