Anti-inflammatory Agents

Question 1

Irreversibly inhibits cyclooxygenase 1 & 2

Answer 1

Aspirin

Question 2

Reversible inhibitor of cyclooxygenase 1 & 2

Answer 2

Ibuprofen

Ketorolac

Question 3

Irreversibly inhibits cyclooygenase 2

Answer 3

Celecoxib

Question 4

Weak and reversible inhibition of cyclooxygenase, antipyretic of choice in pediatric population.

Answer 4

Paracetamol

Question 5

DMARD of choice for Rheumatoid Arthritis

Answer 5

Methotrexate

Question 6

TNF-A blocker

Answer 6

Infliximab

Question 7

Forms 6-Thioguanine, and suppresses B cell & T cell function.

Answer 7

Azathioprine

Question 8

Forms phosphoramide mustard, which cross links DNA to prevent cell replication.

Answer 8

Cyclophosphamide

Question 9

Its active metabolite is Sulfapyridine which inhibits the release of inflammatory cytokines.

Answer 9

Sulfasalazine

Question 10

Inhibits microtubule assembly and LTB4 production leading to decreased macrophage migration and phagocytosis.
SE: Aplastic Anemia

Answer 10

Colchicine

Question 11

Compete with uric acid for reabsorption in the proximal tubules.

Answer 11

Probenecid

Question 12

Active metabolite (alloxanthine) irreversibly inhibits Xanthine Oxidase enzyme and lowers production of Uric acid.

Answer 12

Allopurinol

Question 13

Non-purine, reversible inhibitor of xanthine oxidase, allopurinol intolerance.

Answer 13

Febuxostat