Prions Flashcards
1
Q
Prions
A
Unculturable infectious proteins, Most resistant to disinfectants
2
Q
Most common prion infection
A
Creutzfeldt-Jakob disease (CJD)
3
Q
Other prion diseases
A
Bovine spongiform encephalopathy (BSE)/mad cow, Scrapie, Gerstmann-Straüssler-Scheinker Syndrome, Kuru in humans
4
Q
Gold standard for prion diagnosis
A
Biopsy
5
Q
Papua New Guinea prion disease transmission
A
Cannibalism
6
Q
Methods for killing prions
A
Autoclave 134°C for 18 minutes (prevacuum), Autoclave 132°C for 1 hour (gravity displacement)
7
Q
Prion decontamination with NaOH
A
1N NaOH immersion for 1 hour then autoclave 134°C for 1 hour, or 121°C for 30 minutes (gravity displacement)
