Primary Sclerosing Cholangitis Flashcards
1
Q
What is primary sclerosing cholangitis?
A
Inflammation, fibrosis and strictures of the intra and extra hepatic bile ducts
2
Q
What causes primary sclerosing cholangitis?
A
Unknown
3
Q
What are the symptoms of PSC?
A
Liver failure from chronic biliary obstruction and cirrhosis late stage
Asymptomatic early stage
Painless obstructive jaundice
- Pruritis
4
Q
Signs?
A
Hepatomegaly
Splenomegaly
5
Q
Tests?
A
Bloods
- FBC
- LFTs
ERCP/MRCP
6
Q
What is shown on ERCP?
A
Strictured biliary tree
7
Q
LFT results?
A
Alk Phos up
Bilirubin up
8
Q
Surgical treatment?
A
Cholecystectomy
Liver transplant in late disease
9
Q
Pharma treatment?
A
Pruritis - colestyramine
Cholestasis
- Ursodeoxycolic acid
Antibiotics for bacterial cholangitis
10
Q
What does PSC increase your chances of?
A
Cholangiocarcinoma
