Premature Ovarian Insufficiency

Question 1

What is premature ovarian insufficiency?

Answer 1

Menopause before the age of 40 years

Question 2

What is the hormone profile in premature ovarian insufficiency?

Answer 2

Hypergonadotropic hypogonadism

Raised LH
Raised FSH
Low oestrogen

Question 3

What are causes of premature ovarian insufficiency?

Answer 3

Idiopathic 
Iatrogenic (chemo/RT/surgery)
Autoimmune
Genetic 
Infections

Question 4

What are features of premature ovarian insufficiency?

Answer 4

Oligomenorrhoea

Features of low oestrogen

• hot flushes
• vaginal dryness

Question 5

How is the diagnosis of premature ovarian insufficiency made?

Answer 5

Raised FSH on 2 samples 4 weeks apart

Question 6

How is premature ovarian insufficiency managed?

Answer 6

HRT