Polyagglutination

Question 1

T polyagglutnation

Cleaving enzyme

Answer 1

Neuraminidase

Question 2

Th polyagglutnation

Cleaving enzyme

Answer 2

Neuraminidase

Question 3

Tk polyagglutnation

Cleaving enzyme

Answer 3

B-galactosidase

Question 4

Acquired B polyagglutnation

Cleaving enzyme

Answer 4

Deacetylase

Question 5

Tk polyagglutnation

Decreased expression of which antigens

Answer 5

ABH, Lewis, Ii, P1

Question 6

Tn polyagglutination cause

Answer 6

Somatic mutation resulting i. A lack of B-3-D-galactosyltransferase

Question 7

Cad

Cause

Answer 7

Inherited autosomal dominant

Strong expression of Sda

Question 8

HEMPAS

Answer 8

Autosomal recessive

RBCs have second internal membrane

Question 9

Tr polyagglutination

Answer 9

Autosomal recessive

Membrane proteins not gycosylated

Question 10

Hemoglobin M-Hyde Park Polyagglutination

Answer 10

Caused by 2 unrelated membrane abnormalities, found in a mixed race South African family

Question 11

Laboratory test profile

Answer 11

Positive with group AB adult sera
Negative with cord sera
Negative auto control
Negative DAT

Question 12

Increased reactivity with enzyme treatment

Answer 12

Tk, Cad

Question 13

Decreased reactivity with enzyme treatment

Answer 13

Tn, Th

Question 14

No change in reactivity with enzyme treatment

Answer 14

T, VA, HEMPAS

Question 15

Appropriate cellular products

Answer 15

Washed

Question 16

Appropriate plasma products

Answer 16

Avoid if possible
Use deficient donor
Need minor xm

Question 17

Lectin reactivity in

T

Answer 17

Reacts with

Arachis hypogea 
Glycine max (soja)

Question 18

Lectin reactivity in

Th

Answer 18

Reacts with

Arachis hypogea

Question 19

Lectin reactivity in

Tk

Answer 19

Reacts with

Arachis hypogea
Griffonica simplicofilia II

Question 20

Lectin reactivity in

Tn

Answer 20

Reacts with

Dolichos biflorus
Glycine max (soja)
Salvia sclarea
Salvia hominum 
Grififonica simplicifolia I

Question 21

Lectin reactivity in

Cad

Answer 21

Reacts with

Dolichos biflorus
Glycine max (soja)
Salvia hominum

Question 22

Associated infections

T

Answer 22

Pneumococci, Clostridium perfringens, vibrio cholerae, influenza virus

Question 23

Associated infections

Tn

Answer 23

Clostridia, Bacteroides, E.coli, Proteus

Question 24

Associated infections

Tk

Answer 24

Bacteroides fragilis and Serretia marcescens

Question 25

Associated infections

Tx

Answer 25

Pneumococci

Question 26

Inherited phenotypes

Answer 26

Cad, HEMPAS, NOR, Hemoglobin M Hyde Park