Polyagglutination Flashcards
T polyagglutnation
Cleaving enzyme
Neuraminidase
Th polyagglutnation
Cleaving enzyme
Neuraminidase
Tk polyagglutnation
Cleaving enzyme
B-galactosidase
Acquired B polyagglutnation
Cleaving enzyme
Deacetylase
Tk polyagglutnation
Decreased expression of which antigens
ABH, Lewis, Ii, P1
Tn polyagglutination cause
Somatic mutation resulting i. A lack of B-3-D-galactosyltransferase
Cad
Cause
Inherited autosomal dominant
Strong expression of Sda
HEMPAS
Autosomal recessive
RBCs have second internal membrane
Tr polyagglutination
Autosomal recessive
Membrane proteins not gycosylated
Hemoglobin M-Hyde Park Polyagglutination
Caused by 2 unrelated membrane abnormalities, found in a mixed race South African family
Laboratory test profile
Positive with group AB adult sera
Negative with cord sera
Negative auto control
Negative DAT
Increased reactivity with enzyme treatment
Tk, Cad
Decreased reactivity with enzyme treatment
Tn, Th
No change in reactivity with enzyme treatment
T, VA, HEMPAS
Appropriate cellular products
Washed
Appropriate plasma products
Avoid if possible
Use deficient donor
Need minor xm
Lectin reactivity in
T
Reacts with
Arachis hypogea Glycine max (soja)
Lectin reactivity in
Th
Reacts with
Arachis hypogea
Lectin reactivity in
Tk
Reacts with
Arachis hypogea
Griffonica simplicofilia II
Lectin reactivity in
Tn
Reacts with
Dolichos biflorus Glycine max (soja) Salvia sclarea Salvia hominum Grififonica simplicifolia I
Lectin reactivity in
Cad
Reacts with
Dolichos biflorus
Glycine max (soja)
Salvia hominum
Associated infections
T
Pneumococci, Clostridium perfringens, vibrio cholerae, influenza virus
Associated infections
Tn
Clostridia, Bacteroides, E.coli, Proteus
Associated infections
Tk
Bacteroides fragilis and Serretia marcescens
Associated infections
Tx
Pneumococci
Inherited phenotypes
Cad, HEMPAS, NOR, Hemoglobin M Hyde Park
