Donation Infectious Disease Testing

Question 1

IDM tests performed

Answer 1

HIV: Anti-HIV 1/2(IgG&IgM) and HIV-1 NAT
HCV: Anti-HCV and HCV NAT
HBV: HBsAg, Anti-HBc (IgG&IgM), and HBV NAT
HTLV I/II: Anti-HTLV I/II (IgG)
Syphilis: Treponemal or non-Treponemal
West Nile Virus: NAT
Zika Virus: NAT
Chagas' Disease (T.cruzi IgG)

Question 2

Estimated Risk of Transfusion Transmission:

HIV

Answer 2

1:1,467,000

Question 3

Estimated Risk of Transfusion Transmission:

HCV

Answer 3

1:1,149,000

Question 4

Estimated Risk of Transfusion Transmission:

HBV

Answer 4

1:765,000-1:1,006,000

Question 5

Estimated Risk of Transfusion Transmission:

Bacterial Contamination

Answer 5

1:1,000- 1:3,000

Question 6

HIV permanent deferral

Answer 6

repeat reactive anti-HIV confirmed with positive supplemental test

anti-HIV and HIV NAT positive

Question 7

HIV indefinite deferral with reentry option

Answer 7

repeat reactive anti-HIV 1/2 not confirmed positive

HIV NAT reactive but serology negative

Question 8

Hepatitis B permanent deferral

Answer 8

repeat reactive HBsAG confirmed positive by supplemental testing (HBV NAT or HBsAG antibody neutralization)

Anti-HbC and HbsAg both positive

HBV NAT positive and HBsAg is positive

Question 9

Hepatitis B indefinite deferral with reentry option

Answer 9

HBsAg repeat reactive not confirmed by supplemental test

Anti-HbC positive > 1 time

HBV NAT positive and all serology tests are nonreactive

Question 10

HCV permanent deferral

Answer 10

HCV NAT and serology both positive

Question 11

HCV indefinite deferral with reentry option

Answer 11

Anti-HCV reactive with negative NAT

HCV NAT reactive with negative serologic test

(retest for reentry in 6 months)

Question 12

HTLV deferral

Answer 12

56 day for first occurrence

indefinite for second occurrence

Question 13

syphilis deferral

Answer 13

12 month for confirmed positive

Question 14

syphilis supplemental assay

Answer 14

antigen specific immunoflourescence

Question 15

T.cruzi testing/deferral

Answer 15

donors usually only tested once

positive IgG antibody- indefinite deferral

reentry option in 6 months is supplemental test negative

Question 16

West Nile Virus deferral

Answer 16

120 days for presumed viremic donors (regardless of supplemental test)

Question 17

Zika deferral

Answer 17

120 days for presumed viremic donors (regardless of supplemental test)

Question 18

HIV window

Answer 18

9 days

Question 19

HCV window

Answer 19

7.4 days

Question 20

Additional agents tested for with reproductive tissue donation

Answer 20

Chlamydia trachomatis

Neisseria gonorrhea

Question 21

HBV window

Answer 21

26.5-18.5 days

Question 22

elements of reducing blood bacterial contamination

Answer 22

careful disinfection of donor skin before collection

diversion of first 10-40 ml of collection away from collection bag

Question 23

FDA requires initiation of previous product retrieval after a current reactive donation within

Answer 23

Within 3 days for HIV and HCV

Within 1 week for HBsAg, anti-HBc or anti-HTLV

Question 24

Look back required for

Answer 24

HIV and HCV only