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SBB Review > Blood Components > Flashcards

Blood Components Flashcards

1
Q

Storage Temp

RBCs

A

1-6 C

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2
Q

Storage Temp

Frozen RBCs

A

< -65 C

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3
Q

Storage Temp

FFP

A

< -18 C

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4
Q

Storage Temp

Cryo

A

< -18 C

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5
Q

Storage Temp

Thawed FFP

A

1-6 C

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6
Q

Storage Temp

Thawed cryo

A

20-24 C

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7
Q

Storage Temp

Platelets

A

20-24 C

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8
Q

Storage Temp

Granulocytes

A

20-24 C

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9
Q

Expiration

RBCs CPDA-1

A

35 days

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10
Q

Expiration

RBCs AS-

A

42 days

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11
Q

Expiration

Frozen RBCs

A

10 years

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12
Q

Expiration

Deglycerized RBCs

A

Open system: 24 hr

Closed system: 14 days

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13
Q

Expiration

RBC open system

A

24 hours

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14
Q

Expiration

FFP (-18)

A

12 months

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15
Q

Expiration

FFP

A

7 years

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16
Q

Expiration

Thawed plasma

A

5 days from begin of thaw

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17
Q

Expiration

Liquid plasma

A

5 days after expiration of whole blood

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18
Q

Expiration

Frozen Cryo

A

12 months

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19
Q

Expiration

Thawed cryo

A

6 hours

4 hours if pooled (open system)

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20
Q

Expiration

Platelets

A

5 days

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21
Q

Product QC

RBC

A

Hct < 80%

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22
Q

Frozen RBC considerations

A

Freeze within 6 days of collection if no additive

Additive: freeze before expiration

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23
Q

Rejuvenated RBCs

Rejuvisol limits

A

CPD , CPDA- rejuvenate up to 3 days after expiration

AS-1 rejuvenate up to 42 days then freeze up to 3 hrs

Not approved for AS-3 or AS-5

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24
Q

Purpose of rejuvenating RBCs

A

Restores 2,3-DPG and ATP levels

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25
Q

Deglycerolized RBC QC

A

Mean cell recovery >80%

Adequate removal of glycerol (<1 g remaining)

Minimum free hemoglobin determined by visual inspection of last wash(<3%), refractometor, or osmolality (<400 mOsm/kg H2O)

26
Q

RBC leukoreduced QC

A

Retain >85% of original RBC mass

<5 x10^6 leukocytes per unit

27
Q

FFP must be separated from whole blood and frozen

A

8 hours of collection

28
Q

PF24 must be separated from whole blood and frozen within

A

24 hours of collection

29
Q

PF24 has reduced levels of … compared to FFP

A

Factor V, VIII, and protein C

30
Q

Liquid plasma considerations

A

Contain viable lymphocytes that can cause GVHD

31
Q

Cryo AHF preparation

A

FFP is thawed to 1-6 and the insoluble portion is removed and suspended in approx 15 ml of plasma
Refrozen w/in 1 hr

32
Q

Factors in cryo

A 
Fibrinogen
Von Willebrand factor 
Factor VIII
Factor XIII
fibronectin
33
Q

Minimum factor requirements for cryo

A

150 mg fibrinogen

80 IU factor VIII

34
Q

Cryo reduced plasma

A

Refrozen within 24 hrs of cryo removal

Used for TTP plasma exchange

35
Q

Platelet prep from whole blood

A

Whole blood not cooled below 20C
PRP Method: soft spin followed by hard spin
Resuspended in 40-70ml plasma

36
Q

Platelet QC

A

90% tested:
>5.5 x 10^10 platelets

> 6.2 pH at end of storage

37
Q

Platelet leukoreduced

A

75% tested:
>5.5 x 10^10 platelets

90% tested:
>6.2 pH at end of storage

95% tested:
< 8.3 x 10^5 leukocytes

38
Q

Apheresis platelet leukoreduced QC

A

90% tested:
>3 x 10^11 platelets
> 6.2 pH at end of storage

95% tested:
<5 x 10^6 leukocytes

39
Q

Apheresis granulocytes QC

A

75% tested:

>1 x 10^10 granulocytes

40
Q

Transfusion Indications

RBCs

A

Treatment of symptomatic anemia in normovolemic patients to increase oxygen carrying capacity and cell mass

Generally Hgb < 7, maybe be higher depending on patient factors

41
Q

Transfusion Indications

Platelets

A

Thrombocytopenia

Abnormal platelet function

Prophylactic (plt <10)

42
Q

Transfusion Indications

FFP

A

Bleeding or preop patient who need multiple coag factors

Warfarin reversal

Therapeutic exchange in TTP

Replacement of single factor deficiency when concentrates unavailable

Rare plasma protein deficiency to which concentrates or recombinant products are unavailable

43
Q

Transfusion Indications

Cryo

A

Control of bleeding associated with fibrinogen deficiency (<100)

Treat factor XIII deficiency when recombinant protein unavailable

44
Q

Transfusion Contraindications

RBCs

A

Anemia that can be corrected with medication (B12, iron, erythropoietin)

45
Q

Transfusion contraindications

Platelets

A

Rapid platelet destruction (ITP, DIC)

TTP or HIT

46
Q

Transfusion contraindications

FFP

A

Coagulopathy correctable with specific concentrate or vitamin K

Volume expansion

47
Q

Dosing

RBCs

A

One unit increases Hgb 1g In nonbleeding patient

Pediatric: 10-15 ml/kg

48
Q

Dosing

Platelets

A

1 unit random plt will increase platelet count approx 5000/ ul

49
Q

Dosing

FFP

A

1 ml plasma contains 1 unit coag activity

10-20 ml/kg should increase coag factors by 20%

50
Q

Dosing

Cryo

A

1 unit raises fibrinogen 5-10 mg/dL

Number of bags needed: 0.2x kg body weight

51
Q

Expiration

RBCs CPD or CP2D or ACD

A

21 days

52
Q

Platelet red cell content

A

Generally <1.0 x10^9

If >2 ml of RBCs present, unit must be ABO compatible with recipient plasma and XMd

53
Q

Irradiation

Irradiation sources

A

Gamma rays: cesium-137 or cobalt-60

X-rays

54
Q

Required radiation dose for irradiated products

A

At least 25 gray to the mid plane (no more than 50)

Minimum to any portion 15 Gy

55
Q

Post irradiation expiration

A

28 days or original (whichever is first)

56
Q

platelet storage lesion (3)

A

platelet activation- become spherical shape
increase H+ concentration (decrease pH)
glycoprotein Ib levels decrease

57
Q

Cryo is not produced from

A

Apheresis FFP

58
Q

Refreezing of deglyced units

A

refreeze for 10 years
once thawed expiration is however long the unit had left before refreezing (like a pause, not a restart on the 24 hr expiration)

59
Q

most common glycerol concentration used

A

high concentration: 40%

20% may be used but requires rapid freezing and storage

60
Q

inadequate glycerol removal

A

hemolysis

61
Q

cause of the formation of a semi solid gel mass when deglycing a unit of rbcs

A

sickle cell trait

SBB Review (24 decks)

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